Coordination Funds

协调基金

• 批准号: 455976753
• 负责人: Professor Dr. Paul Zaslansky
• 金额: --
• 依托单位: Abteilung für Zahnerhaltung und Präventivzahnmedizin
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/455976753?language=en
• 关键词: Coordination; Funds

When the clinical need arises, teeth are restored with non-resorbable biomaterials. This usually means that man-made dental materials need to operate for many years under harsh, cyclic loading conditions in the mouth. Initially, the dental surgeon removes pathologic/fractured tissue (e.g. caries) before placing fillings or crowns. To retain the restorations in place, intimate contacts must become established between the restorations and the remaining healthy tooth tissues. Good contact is achieved through formation of ‘interzones’, 3D sheet-like structures comprising intermediate layers with distinct micro-morphologies, compositions and properties. Despite a large range of polymer, ceramic and metal compounds, interzones in artificially constructed tooth restorations are never as good as their natural counterparts that are usually made of simple light organic and mineral components. The reasons for this discrepancy are poorly understood. As a result, dentists often overdesign or underutilize defect-tolerant materials. We propose that a deeper understanding of where and how interzone failure starts, and high resolution analysis of the underlying microstructures can pave the way to designing more durable interzones. Here we propose a research unit "InterDent" that will serve as a platform where materials scientists, engineers and dental clinicians intimately interact within six complementary projects. Whereas project 1 will address the properties and dynamics of chemical aging in dentine, project 2 will unravel the principles of the impressive shear fatigue resistance of the cemento-dentine-junction. Project 3 tries to learn from poor interzones between fillings and dentine, while attempting to benchmark predictors of caries near restorations. Project 4 examines the physical-chemical clues of biofilms attached to dental restorations. Project 5 focuses on the main classes of crown materials and cements to generate a large number of high-resolution simulations of different kinds of damage. Project 6 assesses the dynamics of restoration hardening in the confined space of root canal treatment. By transfer of know-how and data between interdisciplinary researchers, we will identify key parameters needed to predict degradation which we hope to feed back into the clinic. The unique setting of InterDent in Berlin combining advanced material science laboratories with dental clinicians is the ideal fertile soil for an inspiring cooperation leading to novel observations in the fields of InterDent. A major objective of the coordination project is to establish a culture of collaboration between the disciplines for the benefit of a better understanding of interzone phenomena and ultimately better dental treatment.

当临床需要时，用不可吸收的生物材料修复牙齿。这通常意味着人造牙科材料需要在口腔内恶劣的循环载荷条件下运行多年。最初，牙科医生在放置填充物或牙冠之前先去除病理/断裂组织（如龋齿）。为了保持修复体的位置，修复体和剩余的健康牙齿组织之间必须建立密切的接触。通过形成“带间”实现良好的接触，三维片状结构包括具有不同微观形态、成分和性质的中间层。尽管人工构建的牙齿修复体中含有大量的聚合物、陶瓷和金属化合物，但区域间的质量永远不如天然的牙齿修复体好，而天然牙齿修复体通常由简单的轻质有机和矿物成分组成。人们对这种差异的原因知之甚少。因此，牙医经常过度设计或不充分利用耐缺陷材料。我们建议，更深入地了解区域间故障的发生地点和方式，以及对底层微观结构的高分辨率分析可以为设计更耐用的区域间铺平道路。在这里，我们提出了一个研究单位“InterDent”，它将作为材料科学家、工程师和牙科临床医生在六个互补项目中密切互动的平台。项目1将研究牙本质中化学老化的特性和动力学，而项目2将揭示牙骨质-牙本质交界处令人印象深刻的抗剪切疲劳的原理。项目3试图从填充物和牙本质之间的不良区域中学习，同时试图对修复体附近的龋齿进行基准预测。项目4检查附着在牙齿修复体上的生物膜的物理化学线索。项目5主要针对冠材料和胶结物的主要类别，生成大量不同类型损伤的高分辨率模拟。项目6评估根管治疗狭窄空间内修复体硬化的动态。通过跨学科研究人员之间的知识和数据转移，我们将确定预测降解所需的关键参数，我们希望将这些参数反馈到临床。InterDent在柏林的独特设置结合了先进的材料科学实验室与牙科临床医生是一个鼓舞人心的合作，导致在InterDent领域新颖的观察理想的肥沃土壤。协调项目的一个主要目标是在各学科之间建立一种合作文化，以便更好地了解区域间现象，并最终改善牙科治疗。