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Intergenerational transmission of health disparities among Turkish-origin residents in Germany: role of maternal stress and stress biology during pregnancy.

德国土耳其裔居民健康差异的代际传播：怀孕期间孕产妇压力和压力生物学的作用。

基本信息

批准号：
269444679
负责人：
Professorin Dr. Sonja Entringer
金额：
--
依托单位：
Behavioral Perinatology Research Program (aufgelöst)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2015
资助国家：
德国
起止时间：
2014-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/269444679?language=en
关键词：
Intergenerational transmission health disparities among

项目摘要

The importance of addressing the issue of health disparities is well established. Based on the consideration that many of the population health disparities between immigrants of Turkish origin and native Germans that are perpetuated across generations are manifest from the earliest stages of the lifespan onwards, we posit that the origins of these health disparities may trace back, in part, to the effects of maternal social disadvantage on her child's development during the critical period of intrauterine life. We advance the hypothesis that context- and time-inappropriate levels of social disadvantage-related stress biology exposures (maternal-placental-fetal (MPF) endocrine and immune/ inflammatory state) during fetal life may program the structural and functional integrity of cells, tissues and organ systems in a manner that impacts subsequent health and disease risk-related outcomes. As an essential first step towards addressing this hypothesis, we seek to elucidate the effects of maternal migration status and socioeconomic status (the principal proxy measures of social disadvantage) on stress-related MPF biological processes across gestation. We propose to conduct a prospective, longitudinal study in a cohort of Turkish-origin and German-origin pregnant women recruited during early gestation. A unique strength of our proposal is the availability of a cohort of 1500 mother-child dyads of diverse background in terms of their migration status and SES (BaBi-study, BMBF grant 01ER1202, Jacob Spallek, PI) that is currently being recruited. This cohort will be characterized over the course of pregnancy and postnatally with respect to individual and contextual factors and child health outcomes at 0-4 years. The current proposal requests funds to add measures during pregnancy of endocrine (CRH, cortisol) and immune (CRP, IL-6) stress biology at two time points in the second and third trimesters of gestation) in a subgroup of N=300 women (N=150 immigrants of Turkish background, and N=150 native German women). We have assembled an interdisciplinary team of established investigators with complementary expertise. Our study will generate new information about the health of Turkish-origin residents in Germany and shed light on the causes and mechanisms of intergenerational cycles of vulnerability.

解决健康差距问题的重要性是众所周知的。考虑到土耳其裔移民和德国原住民之间代代相传的许多人口健康差异从生命的最早阶段开始就很明显，我们假设这些健康差异的起源可能部分追溯到母亲的社会劣势对她的孩子在宫内生命关键时期的发育的影响。我们提出的假设是，胎儿生命期间与社会劣势相关的应激生物暴露(母体-胎盘-胎儿(MPF)内分泌和免疫/炎症状态)的背景和时间不适当的水平可能会以一种影响后续健康和疾病风险相关结果的方式规划细胞、组织和器官系统的结构和功能完整性。作为解决这一假说的关键的第一步，我们试图阐明母亲的迁移状态和社会经济地位(社会劣势的主要替代指标)对妊娠期间与应激相关的MPF生物过程的影响。我们建议对早期妊娠期间招募的土耳其裔和德国裔孕妇进行一项前瞻性的纵向研究。我们建议的一个独特优势是，根据移民状况和目前正在招募的社会经济专家(BABI-Study，BMBF赠款01ER1202，Jacob Spallek，PI)，提供1500名具有不同背景的母子二人组。这一群体将在怀孕期间和出生后根据个人和背景因素以及0-4岁儿童的健康结果来确定特征。目前的提案要求提供资金，在N=300名妇女(N=150名土耳其背景移民，N=150名德国土著妇女)中增加孕期内分泌(CRH、皮质醇)和免疫(CRP、IL-6)应激生物学的措施(在怀孕中期和晚期两个时间点)。我们已经组建了一支由具有互补专业知识的资深调查人员组成的跨学科团队。我们的研究将产生关于德国土耳其裔居民健康的新信息，并阐明易受伤害的代际循环的原因和机制。