The development and evaluation of super high resolution MR microscopy.

超高分辨率磁共振显微镜的开发和评估。

• 批准号: 11470187
• 负责人: IKEHIRA Hiroo
• 金额: $ 2.88万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470187/
• 关键词: NMR; MR microscopy; MRI; special resolution; pulse sequence

It suited pursuing resolution between the high-spatial-resolution of the performance limit in 1999 using the gradient coil of MRI for research of currently possessed, and a highly efficient through rate. Between the high-spatial-resolution of the first year, the concrete achievement target of resolution should be 50 micrometers and the target of the 1st phase was the creation of the spin echo method pulse sequence for achievement and the small volume coil aiming at mouse size are made as an experiment The possibility of resolution was experimentally examined between the further high-spatial-resolution from the result of the S/N measurement and the picture using such hard software. In 2000, high resolution imaging in the equipment for clinical of 1.5T, hybrid equipment was manufactured and adjustment and a check of the practicality were performed the highest of the picture which made the homemade coil for a saddle type MR microscopy and was obtained in the last year using the coil, and the result which resolution became about 30 microns per pixel, and exceeded far the prospective target value of 100 to 50 microns was obtained This resolution is considered from S/N expected by 1.5T, and is presumed to be almost close to a theoretical marginal value. However, high spatial resolution MR image, many problems which contrast, S/N and vibration, and a photographic subject should motion-etc.-solve are left behind future with the equipment for clinical of 1.5T, high spatial resolution by enforcing the optimal pulse sequence for imaging examines the possibility of clinical application furthermore, between the resolution obtained using development of a highly efficient high sensitivity probe, simultaneously pathology data, etc. It is thought that it is necessary perform comparison examination with an high resolution MRI picture and to perform clinical technical evaluation in parallel

它适合于在1999年使用MRI的梯度线圈进行研究的性能极限的高空间分辨率和高效的通过率之间追求分辨率。从第一年的高空间分辨率，分辨率的具体实现目标应该是50微米，第一阶段的目标是创建用于实现的自旋回波方法脉冲序列和针对小鼠尺寸的小体积线圈作为实验。N的测量和图片使用这样的硬软件。2000年，制造了1.5T混合设备的临床设备中的高分辨率成像，并进行了调整和实用性检查，最高的图像是自制的鞍型MR显微镜线圈，并在去年使用线圈获得，分辨率变为约30微米/像素的结果，并且远远超过了100至50微米的预期目标值。该分辨率是从S/N预期1.5T考虑的，并且被认为几乎接近理论临界值。然而，高空间分辨率的MR图像，许多问题，如对比度，S/N和振动，以及摄影主体应运动等。解决了落后于未来的1.5T的临床设备，通过实施用于成像的最佳脉冲序列的高空间分辨率检查临床应用的可能性。此外，在使用高效高灵敏度探头的开发获得的分辨率，同时病理数据，认为有必要用高分辨率MRI图像进行比较检查，并同时进行临床技术评价

项目成果

Perfusion recovery after lung volume reduction surgery.

肺减容手术后的灌注恢复。

• 发表时间: 1999
• 期刊: Clin.Nucl.Med. 24
• 作者: Watanabe N;Tanada S et al.
• 通讯作者: Tanada S et al.

Ikehira H et al.: "ong-term assessment of post-transplant renal prognosis with 31P magnetic resonance spectroscopy."Transplantation. (In press). (2000)

Ikehira H 等人：“利用 31P 磁共振波谱对移植后肾脏预后进行长期评估。”移植。

MRI/MRSによる診断-MRIはどうして画になるのか-

MRI/MRS 诊断 - MRI 如何产生图像？

• 发表时间: 2000
• 作者: 池平博夫

Seizure frequency and bilateral temporal abnormalities : a proton magnetic resonance spectroscopy of temporal lobe epilepsy.

癫痫发作频率和双侧颞叶异常：颞叶癫痫的质子磁共振波谱。

• 发表时间: 2000
• 期刊: Seizure 9
• 作者: Ikehira H et al.

Ikehira H.et al.: "Multiple Extra Bone Accumulations of Technetium-99m Hydroxymethylene Diphosphonate"Journal of Nuclear Medicine Technology. 27. 41-42 (1999)

Ikehira H.等人：“Technetium-99m 羟亚甲基二磷酸盐的多重额外骨积累”核医学技术杂志。