The development and evaluation of super high resolution MR microscopy.

它适合于在1999年利用磁共振梯度线圈研究目前拥有的性能极限的高空间分辨率和高效通过率之间追求分辨率。high-spatial-resolution之间的第一年,决议的具体成就目标应该是50微米和第一阶段的目标是创建自旋回波脉冲序列方法的成就和体积小线圈针对老鼠的大小是由作为实验决议的可能性之间的实验研究进一步high-spatial-resolution S / N测量的结果和图片使用这些软件。2000年，在1.5T的临床高分辨率成像设备上制造了混合设备，并对去年使用该线圈制作的鞍式磁共振显微镜用线圈的最高图像进行了调整和实用性检验，其结果分辨率达到每像素30微米左右。并且远远超过了100 ~ 50微米的预期目标值，该分辨率从1.5T期望的信噪比考虑，假定几乎接近理论边际值。然而，高空间分辨率磁共振图像存在对比度、信噪比和振动、拍摄对象运动等诸多问题。-解决未来留给临床的1.5T设备，高空间分辨率通过强制最佳脉冲序列进行成像检查临床应用的可能性进一步，利用开发的高效高灵敏度探针获得的分辨率，同时病理数据等。认为有必要与高分辨率MRI图像进行对比检查，同时进行临床技术评价

It suited pursuing resolution between the high-spatial-resolution of the performance limit in 1999 using the gradient coil of MRI for research of currently possessed, and a highly efficient through rate. Between the high-spatial-resolution of the first year, the concrete achievement target of resolution should be 50 micrometers and the target of the 1st phase was the creation of the spin echo method pulse sequence for achievement and the small volume coil aiming at mouse size are made as an experiment The possibility of resolution was experimentally examined between the further high-spatial-resolution from the result of the S/N measurement and the picture using such hard software. In 2000, high resolution imaging in the equipment for clinical of 1.5T, hybrid equipment was manufactured and adjustment and a check of the practicality were performed the highest of the picture which made the homemade coil for a saddle type MR microscopy and was obtained in the last year using the coil, and the result which resolution became about 30 microns per pixel, and exceeded far the prospective target value of 100 to 50 microns was obtained This resolution is considered from S/N expected by 1.5T, and is presumed to be almost close to a theoretical marginal value. However, high spatial resolution MR image, many problems which contrast, S/N and vibration, and a photographic subject should motion-etc.-solve are left behind future with the equipment for clinical of 1.5T, high spatial resolution by enforcing the optimal pulse sequence for imaging examines the possibility of clinical application furthermore, between the resolution obtained using development of a highly efficient high sensitivity probe, simultaneously pathology data, etc. It is thought that it is necessary perform comparison examination with an high resolution MRI picture and to perform clinical technical evaluation in parallel