Development of a quantitative diagnostic method of ^<19>F drug metabolism using clinical MRI

由于科研资助已于1998年结束，我们成功地以临床剂量观察到来自人体的^<19>F-MRS信号。本初步实验获得的^<19>F信号在消化器官肿瘤手术后的进展良好，约有1例患者在服用抗肿瘤药物5-FU的同时，通过常规治疗过程从肝域获得处方下的5-FU信号。虽然本病例的用药量相对较少，只有100mg或更少，但由于获得了良好的信号，为了进一步推进作为临床诊断方法的部署研究，从而进一步制定直接的医疗方案，1999年建立了5-FU、抗精神病药物、麻醉药物临床设备的测量方法，测量限度的检查。并将最佳测量方法的参数作为氟化物含量的药物曲线，多用于目前医疗用品中对^<19 b> F-MRS的评价。采用动态MRS测量方法进行生物体内同化和异化代谢的药物动力学，并从药物代谢的角度对肝功能评价和药代动力学进行评价研究。这些研究成果可供参考。2000年对临床研究设备进行了更新，尝试了与独立式多核素测量光谱仪的混合组合，并正在建设可在临床研究设备内自由进行多核素测量的系统。此外，还进行了开发和调整，以便从临床设备上进行直接氟化物等的测量。2001年公布了多核素光谱和利用光谱成像方法的研究成果，作为提高氟化物测量灵敏度的环隙线圈的试制检验。在一张图片（^<19>F-CSI）中也成功地定位了一个存托代理，目前的结果正在贡献中。贮存剂的空间分布和代谢评价是今后部署研究的重要目标之一。少

As a result of the grant-in-aid for scientific research already ended by 1998, we succeeded in observing the signal from the human body of ^<19>F-MRS by the amount of clinical dose. The progress after a digestive organ neoplasm operation of the signal of ^<19>F obtained in this preliminary experiment is good, and the signal of 5-FU under recipe is acquired from a liver domain through the usual medical treatment course about a case while taking 5-FU which is an anti-neoplasm agent. Although the amount of medication in this case is comparatively as little as 100mg or less, since the good signal was acquired, in order to advance deployment research as a clinical diagnostic method which leads to a direct medical treatment plan further, 1999 set up establishment of the measuring method in the equipment for clinical of 5-FU, anti-psychosis medicine, and an anesthetic drug, the check of a measurement limit, and the parameter of the optimal measuring method as a fluoride content medicine curre … More ntly used as present medical supplies about evaluation of ^<19>F-MRS. Pharmaceutical kinetics of assimilation and dissimilation metabolism in the living body was performed with the dynamic MRS measuring method, and evaluation research on the liver function evaluation and the pharmacokinetics, which were seen from medicine metabolism, was also done. These researches were exhibited as reference. The research equipment for clinical is updated in 2000, hybrid composition with the independent type spectro-meter for multi-nuclide measurement is tried, and the system which can perform multi-nuclide measurement freely within the equipment for clinical is under construction. Moreover, development and adjustment are performed so that measurement of direct fluoride etc. can be performed from the equipment for clinical. In 2001, the multi-nuclide spectrum and the research result using spectroscopic imaging methods were announced as the trial production examination of the loop gap coil for a raise in the sensitivity of fluoride measurement. Localization of a depository agent is succeeded also in a picture (^<19>F-CSI), and the present result is under contribution. It is one of the important targets of the future deployment research to evaluate of a spatial distribution and metabolism of a depository agent. Less