Development of a quantitative diagnostic method of ^<19>F drug metabolism using clinical MRI

由于科学研究资助已于1998年结束，我们成功地通过临床剂量观察到了来自人体的信号。本实验获得的5-FU信号在消化器官肿瘤手术后进展良好，方剂下的5-FU信号是在服用抗肿瘤药物5-FU的同时，通过一个病例的常规内科疗程从肝域获得的。虽然这种情况下的用药量相对较少，只有100 mg或更少，但由于获得了良好的信号，为了推进作为临床诊断方法的部署研究，从而进一步指导医疗计划，1999年在5-FU、抗精神病药物和麻醉药的临床设备中建立了测量方法，检查了测量极限，并将最佳测量方法的参数设置为氟化物含量药物Curre…更多地用作医疗用品关于评价^&lt；19&>F-MRS。采用动态MRS测量方法进行了活体同化和异化代谢的药物动力学研究，并从药物代谢的角度对肝功能评价和药代动力学进行了评价研究。这些研究成果可供参考。2000年对临床研究设备进行了更新换代，尝试了与独立式多核素测量光谱仪的混合组合，并正在建设可在临床设备内自由进行多核素测量的系统。此外，还进行了开发和调整，以便从临床设备上进行直接氟化物等的测量。2001年，为提高氟化物测量的灵敏度，公布了多核素能谱和光谱成像方法的研究结果，作为环隙线圈的试生产检验。一张图片(^&lt；19&gt；F-CSI)也成功地实现了托管代理的本地化，目前的结果正在贡献中。对储存剂的空间分布和代谢进行评价是未来部署研究的重要目标之一。较少

As a result of the grant-in-aid for scientific research already ended by 1998, we succeeded in observing the signal from the human body of ^<19>F-MRS by the amount of clinical dose. The progress after a digestive organ neoplasm operation of the signal of ^<19>F obtained in this preliminary experiment is good, and the signal of 5-FU under recipe is acquired from a liver domain through the usual medical treatment course about a case while taking 5-FU which is an anti-neoplasm agent. Although the amount of medication in this case is comparatively as little as 100mg or less, since the good signal was acquired, in order to advance deployment research as a clinical diagnostic method which leads to a direct medical treatment plan further, 1999 set up establishment of the measuring method in the equipment for clinical of 5-FU, anti-psychosis medicine, and an anesthetic drug, the check of a measurement limit, and the parameter of the optimal measuring method as a fluoride content medicine curre … More ntly used as present medical supplies about evaluation of ^<19>F-MRS. Pharmaceutical kinetics of assimilation and dissimilation metabolism in the living body was performed with the dynamic MRS measuring method, and evaluation research on the liver function evaluation and the pharmacokinetics, which were seen from medicine metabolism, was also done. These researches were exhibited as reference. The research equipment for clinical is updated in 2000, hybrid composition with the independent type spectro-meter for multi-nuclide measurement is tried, and the system which can perform multi-nuclide measurement freely within the equipment for clinical is under construction. Moreover, development and adjustment are performed so that measurement of direct fluoride etc. can be performed from the equipment for clinical. In 2001, the multi-nuclide spectrum and the research result using spectroscopic imaging methods were announced as the trial production examination of the loop gap coil for a raise in the sensitivity of fluoride measurement. Localization of a depository agent is succeeded also in a picture (^<19>F-CSI), and the present result is under contribution. It is one of the important targets of the future deployment research to evaluate of a spatial distribution and metabolism of a depository agent. Less