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Development of a quantitative diagnostic method of ^<19>F drug metabolism using clinical MRI

利用临床MRI开发^ 19 F药物代谢的定量诊断方法

基本信息

批准号：
11557067
负责人：
IKEHIRA Hiroo
金额：
$ 3.65万
依托单位：
National Institute of Radiological Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11557067/
关键词：
NMR MR microscopy MRI special resolution pulse sequence 肝機能

项目摘要

As a result of the grant-in-aid for scientific research already ended by 1998, we succeeded in observing the signal from the human body of ^<19>F-MRS by the amount of clinical dose. The progress after a digestive organ neoplasm operation of the signal of ^<19>F obtained in this preliminary experiment is good, and the signal of 5-FU under recipe is acquired from a liver domain through the usual medical treatment course about a case while taking 5-FU which is an anti-neoplasm agent. Although the amount of medication in this case is comparatively as little as 100mg or less, since the good signal was acquired, in order to advance deployment research as a clinical diagnostic method which leads to a direct medical treatment plan further, 1999 set up establishment of the measuring method in the equipment for clinical of 5-FU, anti-psychosis medicine, and an anesthetic drug, the check of a measurement limit, and the parameter of the optimal measuring method as a fluoride content medicine curre … More ntly used as present medical supplies about evaluation of ^<19>F-MRS. Pharmaceutical kinetics of assimilation and dissimilation metabolism in the living body was performed with the dynamic MRS measuring method, and evaluation research on the liver function evaluation and the pharmacokinetics, which were seen from medicine metabolism, was also done. These researches were exhibited as reference. The research equipment for clinical is updated in 2000, hybrid composition with the independent type spectro-meter for multi-nuclide measurement is tried, and the system which can perform multi-nuclide measurement freely within the equipment for clinical is under construction. Moreover, development and adjustment are performed so that measurement of direct fluoride etc. can be performed from the equipment for clinical. In 2001, the multi-nuclide spectrum and the research result using spectroscopic imaging methods were announced as the trial production examination of the loop gap coil for a raise in the sensitivity of fluoride measurement. Localization of a depository agent is succeeded also in a picture (^<19>F-CSI), and the present result is under contribution. It is one of the important targets of the future deployment research to evaluate of a spatial distribution and metabolism of a depository agent. Less

由于科学研究资助已于1998年结束，我们成功地通过临床剂量观察到^ 19 F-MRS的人体信号。在该初步实验中获得的^ 19 F信号在消化器官肿瘤手术后的进展良好，并且对于服用作为抗肿瘤剂的5-FU的情况，通过通常的治疗过程从肝脏区域获得处方下的5-FU信号。虽然本例中的用药量相对较少，只有100mg以下，但由于获得了良好的信号，为了进一步推进作为临床诊断方法的部署研究，从而进一步制定直接的医疗计划，1999年制定了5-FU、抗精神病药物和麻醉药物的临床设备中的测量方法的建立、测量限度的检查以及作为氟化物的最佳测量方法的参数内容医学目前用作^<19>F-MRS评估的现有医疗用品。采用动态MRS测量方法进行了体内同化和异化代谢的药物动力学研究，并从药物代谢的角度对肝功能评价和药代动力学进行了评价研究。这些研究成果被展出作为参考。 2000年更新了临床研究设备，尝试与独立式多核素测量光谱仪混合组成，在临床设备内自由进行多核素测量的系统正在建设中。另外，为了能够从临床用设备直接测定氟化物等，进行了开发和调整。 2001年，为了提高氟化物测量的灵敏度，作为环形间隙线圈的试制检查，公布了多核素光谱和利用光谱成像方法的研究结果。图(^<19>F-CSI)中，保管代理人的本地化也成功，目前的成果正在投稿中。评估沉积剂的空间分布和代谢是未来部署研究的重要目标之一。较少的