MR MICROSCOPY OF A RAT PRENATAL COCAINE EXPOSURE MODEL

大鼠产前可卡因暴露模型的 MR 显微镜检查

• 批准号: 8363193
• 负责人: Josephine M. Johns
• 金额: $ 0.61万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363193
• 关键词: Brain; Cocaine; Data; Development; Female; Fetal Cocaine Exposure; Funding; Grant; Human Development; Microscopy; Modeling; Mothers; National Center for Research Resources; Postpartum Period; Principal Investigator; Rattus; Research; Research Infrastructure; Resolution; Resources; Scanning; Source; Structure; Third Pregnancy Trimester; Time; United States National Institutes of Health; cost; interest; male; offspring; postnatal; ultra high resolution

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are explorng the developmental effects of prenatal cocaine exposure in a rat model. Little data actually exist regarding the effects of cocaine during development, thus the need for such studies are great. Here at UNC, we are doing high-resolution DTI scans, but the facilities here are not equipped to do ultra-high resolution MR microscopy. Thus, we have discussed with Al Johnson the potential to explore this aim at Duke. Our DTI studies are currently performed in rat mothers treated with cocaine on postpartum day 5, and in the male and female offspring of these mothers on postnatal days 5 and 14, roughly trnaslational to the end of the third trimester and approximately 1 week old in human development. If differences in brain structure are found at these time points, we are interested in exploring later time points to determine the long term developmental effects of prenatal cocaine exposure.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们正在探索产前可卡因暴露对大鼠模型发育的影响。 关于可卡因在发育过程中的影响，实际上几乎没有数据，因此非常需要进行这类研究。 在斯坦福大学，我们正在做高分辨率的DTI扫描，但这里的设备不具备超高分辨率的MR显微镜。 因此，我们已经与Al约翰逊讨论了在杜克探索这一目标的潜力。 我们的DTI研究目前在产后第5天用可卡因处理的大鼠母亲中进行，并在产后第5天和第14天在这些母亲的雄性和雌性后代中进行，大约在人类发育的第三个三个月结束时和大约1周龄时进行。 如果在这些时间点发现大脑结构的差异，我们有兴趣探索以后的时间点，以确定产前可卡因暴露的长期发育影响。