Topical therapy for the treatment of inner ear deafness, tinnitus and vertigo

局部疗法治疗内耳性耳聋、耳鸣、眩晕

• 批准号: 11470355
• 负责人: NAKASHIMA Tsutomu
• 金额: $ 6.27万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470355/
• 关键词: cochlea; topical therapy; hearing loss; tinnitus; vertigo; cochlear blood flow; 耳鳴; ソフトレーザー; プロスタグランディン; メニエール病; ゲンタマイシン

Prospective, randomized double-blind study was performed to evaluate effectiveness of 60-mW laser irradiation in the treatment of tinnitus. No significant difference was observed between the active and placebo laser groups with regard to outcome of loudness, duration, quality, and annoyance of tinnitus.Recently, there have been many reports describing efficacy of intratympanic gentamicin injection for the treatment of intractable vertigo in patients with Meniere's disease. Using guinea pigs, we measured gentamicin concentration of perilymph in the basal turn of the cochlea after topical application of gentamicin to the round window. After about 1 or 2 hours, the gentamicin concentration reached a maximum level and then decreased, with a half-life of two or several hours.Vestibular compensation is expected after the intratympanic gentamicin therapy. Even after the vestibular compasation was considered complete clinically, vertical eye-movement oscillation with a frequency double that of … More lateral linear acceleration was observed.We suggested that α-tocopherol suppresses CDDP-induced ototoxicity. We also found that prostaglandin E1 put on the round window elevated cochlear blood flow in guinea pigs.The effects of anterior inferior cerebellar artery (AICA) occlusion on cochlear blood flow were investigated in rats using the laser-Doppler and microsphere methods. We inferred that during complete interruption of cochlear blood flow in rats, residual laser-Doppler output was essentially attributable to blood flow in the bone surrounding the cochlea. Accordingly, we considered that blood flow in the bone which surrounds the cochlea should not be neglected.We measured cochlear blood flow in 20 patients who received cochlear implants using a laser-Doppler probe before, during, and after the cochlear bony wall had been opened. There were six cases in which significant reduction of cochlear blood flow was recognized ; two patients with idiopathic progressive sensorineural hearing loss, two congenital deaf patients with unknown cause, one patient with narrow internal auditory canal, one postmeningitic deaf patient. Less

进行了前瞻性，随机的双盲研究，以评估60兆瓦激光照射在耳鸣治疗中的有效性。在响度，持续时间，质量和烦恼的结果方面，主动和安慰剂激光组之间没有明显差异。使用豚鼠，我们在耳蜗的基本转弯中测量了庆大霉素在圆形窗户上的局部使用后，在耳蜗的基本转弯中测量了庆大霉素浓度。大约1或2个小时后，庆大霉素浓度达到最大水平，然后改善，半衰期为两个或几个小时。预计在内胰腺内庆大霉素治疗后，预计将获得vistibular补偿。即使在前庭组合被完全临床视为临床上，垂直眼动振荡的频率双倍，即……更多的侧向线性加速度的频率。我们建议α-生育酚抑制CDDP诱导的耳毒性。我们还发现，将前列腺素E1放在豚鼠中的圆窗上升高的耳蜗血流升高。在使用激光型配套和微层方法的大鼠中研究了抗eL-El-El-El-El-El-El-El-El-El-El-Elion suster-Cerebellar动脉（AICA）闭塞对耳蜗血流的影响。我们推断，在大鼠的耳蜗血流完全中断时，残留的激光多普勒输出基本上归因于耳蜗周围的骨骼中的血流。彼此之间，我们认为不应忽略耳蜗周围的骨骼中的血液流动。我们测量了20例使用激光多普勒探针接收耳蜗植入的患者的耳蜗血流，此前，期间和之后已打开了耳蜗围墙。在六种情况下，认识到耳蜗血流的大幅降低。两名患有特发性进行性感觉神经性听力损失的患者，两名先天性聋患者，病因不明，一名患者内部听觉运河狭窄，一名出现后聋哑患者。

项目成果

Nakashima T, et al.: "Intratympanic gentamicin therapy for delayed endolymphatic hydrops and Meniere's disease"Folia Otorhinolaryngologica. 6. 73-78 (2000)

Nakashima T 等人：“鼓室内庆大霉素治疗迟发性内淋巴积水和梅尼埃病”Folia Otorhinolaryngologica。

Tsutomu Nakashima: "Autoregulation of cochlear blood flow"Nagoya J.Med.Sci. 62. 1-9 (1999)

中岛努：“耳蜗血流的自动调节”名古屋医学科学杂志。

中島 務: "難病の診断と治療指針 改訂版2"六法出版社. 371-379 (2001)

中岛勉：《疑难杂症诊断治疗指南修订版2》六穗出版371-379。

Iwashima Y, et al.: "Vertical eye-movement oscillation with a frequency double that of lateral linear acceleration in patients with long-standing unilateral vestibular loss"Auris Nasus Larynx. (in press).

Iwashima Y 等人：“长期单侧前庭丧失患者的垂直眼球运动振荡频率是横向线性加速度的两倍”Auris Nasus Larynx。

中島 務: "突発性難聴における耳鳴、耳閉感"Audiology Japan. 42. 710-716 (1999)

Tsutomu Nakajima：“突发性听力损失中的耳鸣和听觉饱满度”日本听力学 42. 710-716 (1999)。