Topical therapy for the treatment of inner ear deafness, tinnitus and vertigo

局部疗法治疗内耳性耳聋、耳鸣、眩晕

• 批准号: 11470355
• 负责人: NAKASHIMA Tsutomu
• 金额: $ 6.27万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470355/
• 关键词: cochlea; topical therapy; hearing loss; tinnitus; vertigo; cochlear blood flow; 耳鳴; ソフトレーザー; プロスタグランディン; メニエール病; ゲンタマイシン

Prospective, randomized double-blind study was performed to evaluate effectiveness of 60-mW laser irradiation in the treatment of tinnitus. No significant difference was observed between the active and placebo laser groups with regard to outcome of loudness, duration, quality, and annoyance of tinnitus.Recently, there have been many reports describing efficacy of intratympanic gentamicin injection for the treatment of intractable vertigo in patients with Meniere's disease. Using guinea pigs, we measured gentamicin concentration of perilymph in the basal turn of the cochlea after topical application of gentamicin to the round window. After about 1 or 2 hours, the gentamicin concentration reached a maximum level and then decreased, with a half-life of two or several hours.Vestibular compensation is expected after the intratympanic gentamicin therapy. Even after the vestibular compasation was considered complete clinically, vertical eye-movement oscillation with a frequency double that of … More lateral linear acceleration was observed.We suggested that α-tocopherol suppresses CDDP-induced ototoxicity. We also found that prostaglandin E1 put on the round window elevated cochlear blood flow in guinea pigs.The effects of anterior inferior cerebellar artery (AICA) occlusion on cochlear blood flow were investigated in rats using the laser-Doppler and microsphere methods. We inferred that during complete interruption of cochlear blood flow in rats, residual laser-Doppler output was essentially attributable to blood flow in the bone surrounding the cochlea. Accordingly, we considered that blood flow in the bone which surrounds the cochlea should not be neglected.We measured cochlear blood flow in 20 patients who received cochlear implants using a laser-Doppler probe before, during, and after the cochlear bony wall had been opened. There were six cases in which significant reduction of cochlear blood flow was recognized ; two patients with idiopathic progressive sensorineural hearing loss, two congenital deaf patients with unknown cause, one patient with narrow internal auditory canal, one postmeningitic deaf patient. Less

采用前瞻性随机双盲研究方法，评价60 mW激光照射治疗耳鸣的疗效。在耳鸣的响度、持续时间、质量和烦恼方面，活性和安慰剂激光组之间没有观察到显著差异。最近，有许多报道描述了鼓室内注射庆大霉素治疗梅尼埃病患者顽固性眩晕的疗效。用豚鼠，在圆窗局部应用庆大霉素后，我们测定耳蜗底回外淋巴液中庆大霉素的浓度。庆大霉素在鼓室内给药1 ~ 2小时后，浓度达到最大值，然后逐渐下降，半衰期为2 ~数小时。即使在临床上认为前庭补偿完成后，垂直眼动振荡的频率也是 ...更多信息 提示α-生育酚可抑制CDDP诱导的耳毒性。用激光多普勒法和微球法观察了大鼠小脑前下动脉（AICA）闭塞对耳蜗血流的影响。我们推断，在大鼠耳蜗血流完全中断期间，残余激光多普勒输出基本上归因于耳蜗周围骨骼中的血流。因此，我们认为，血流量在骨周围的cochle. We不应该被忽略，我们测量了耳蜗血流量在20例接受人工耳蜗植入使用激光多普勒探头之前，期间，和之后的耳蜗骨壁已被打开。有6例患者的耳蜗血流明显减少，其中2例为特发性进行性感音神经性听力损失，2例原因不明的先天性耳聋患者，1例内听道狭窄患者，1例脑膜炎后耳聋患者。少

项目成果

中島 務: "難病の診断と治療指針 改訂版2"六法出版社. 371-379 (2001)

中岛勉：《疑难杂症诊断治疗指南修订版2》六穗出版371-379。

Nakashima T, et al.: "Intratympanic gentamicin therapy for delayed endolymphatic hydrops and Meniere's disease"Folia Otorhinolaryngologica. 6. 73-78 (2000)

Nakashima T 等人：“鼓室内庆大霉素治疗迟发性内淋巴积水和梅尼埃病”Folia Otorhinolaryngologica。

Tsutomu Nakashima: "Autoregulation of cochlear blood flow"Nagoya J.Med.Sci. 62. 1-9 (1999)

中岛努：“耳蜗血流的自动调节”名古屋医学科学杂志。

Iwashima Y, et al.: "Vertical eye-movement oscillation with a frequency double that of lateral linear acceleration in patients with long-standing unilateral vestibular loss"Auris Nasus Larynx. (in press).

Iwashima Y 等人：“长期单侧前庭丧失患者的垂直眼球运动振荡频率是横向线性加速度的两倍”Auris Nasus Larynx。

中島 務: "突発性難聴における耳鳴、耳閉感"Audiology Japan. 42. 710-716 (1999)

Tsutomu Nakajima：“突发性听力损失中的耳鸣和听觉饱满度”日本听力学 42. 710-716 (1999)。