Evaluation of inner ear blood flow with laser speckle flowgraphy

激光散斑血流成像评估内耳血流

• 批准号: 15390515
• 负责人: NAKASHIMA Tsutomu
• 金额: $ 7.87万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390515/
• 关键词: Cochlea; Blood flow; Laser; Speckle; Schwartze sign; Otosclerosis; Venous congestion; 内耳; レーザースペックル; レーザードップラー; レーザースッペクル; 感音難聴

The cochlea is principally supplied from the inner ear artery (labyrinthine artery), which is usually a branch of the anterior inferior cerebellar artery (AICA). The human cochlea is not easily accessible for investigation because this delicate sensory organ is hidden deep in the temporal bone. However, we could measure cochlear blood flow (CBF) in patients who received cochlear implants, using a laser-Doppler probe placed over the site of drilling in the cochlear bony wall. In the patients with idiopathic progressive sensorineural hearing loss, the CBF was significantly lower in patients more than 40 years old. Intracochlear calcification following meningitis also appeared to be associated with a reduced CBF.Using lase-speckle flowgraphy, pulsation of the AICA was observed in rats, but evaluation of the CBF itself was very difficult. However, in patients with cochlear otosclerosis, blood flow to the promontory was evaluated using the laser-speckle flowgraphy. It has been reported that vascular shunts exist between the cochlea and the surrounding bone in cochlear otosclerosis. Some authors speculated that these vascular shunts might represent collateral circulation from the membraneous cochlea, which bypasses the reduced or absent capillary networks of the spiral ligament and drains into the vessels of the otosclerotic focus. In our study, patients with otosclerosis exhibited elevated and pulsating blood flow to the promontory with the Schwartze sign. The Schwartze sign correlated significantly with otosclerotic lesions invading the promontory. It is possible that blood flow inside the cochlea decreases due to the venous congestion in cochlear otosclerosis. If so, blood flow differs between the inside and outside of the cochlea in cochlear otosclerosis

耳蜗主要由内耳动脉（内耳动脉）供应，内耳动脉通常是小脑前下动脉（AICA）的分支。人类的耳蜗并不容易接近进行研究，因为这个微妙的感觉器官隐藏在颞骨深处。然而，我们可以测量耳蜗血流量（CBF）的患者接受人工耳蜗植入，使用激光多普勒探头放置在耳蜗骨壁钻孔的网站。在进行性感音神经性聋患者中，年龄大于40岁的患者CBF显著降低。脑膜炎后颅内钙化似乎也与CBF.Using激光斑点血流图，AICA的脉动在大鼠中观察到，但CBF本身的评价是非常困难的。然而，在患有耳蜗性耳硬化症的患者中，使用激光散斑血流图来评估流向海角的血流。有文献报道耳蜗性耳硬化症的耳蜗与周围骨之间存在血管分流。一些作者推测，这些血管分流可能代表来自膜耳蜗的侧支循环，其绕过螺旋韧带的减少或缺失的毛细血管网络并流入耳硬化病灶的血管。在我们的研究中，耳硬化症患者表现出升高和脉动的血流量与施瓦兹征的海角。Schwartze征与侵犯岬的耳硬化病变显著相关。耳蜗内的血流可能由于耳蜗耳硬化症的静脉充血而减少。如果是这样的话，在耳蜗性耳硬化症中，耳蜗内外的血流是不同的

项目成果

Image diagnosis of sensorineural hearing loss.

感音神经性听力损失的影像诊断。

• 发表时间: 2004
• 期刊: Practica Oto-Rhino-Laryngologica 97
• 作者: Nakashima T;Misawa H;Sone M;Kobayashi M;Sugiura M.;Nakashima T.
• 通讯作者: Nakashima T.

Effects of round window membrane rupture on cochlear blood flow and endcochlear potential.

圆窗膜破裂对耳蜗血流和耳蜗电位的影响。

• 发表时间: 2003
• 期刊: Nippon Jibiinnkouka Gakkai Kiho 06
• 作者: Liu X;Sone M;Tominaga M;Hayashi H;Yamamoto H;Nakashima T.
• 通讯作者: Nakashima T.

両側変動性感音難聴をきたした特発性低音髄圧症候群の一例

特发性低音脊髓压迫综合征伴双侧波动性感音神经性耳聋一例

• 发表时间: 2004
• 期刊: Audiol Jpn 48
• 作者: 杉浦真;橋本彩恵;曾根三千彦;中島務
• 通讯作者: 中島務

Response of cochlear blood flow to prostaglandin E1 applied topically to the round window.

耳蜗血流对局部应用于圆窗的前列腺素 E1 的反应。

• 发表时间: 2006
• 期刊: Acta Otolaryngol. 126
• 作者: Tominaga M.;Yamamoto H.;Sone M.;Teranishi M.;Nakashima T.
• 通讯作者: Nakashima T.

流行性耳下腺炎(ムンプス)と難聴

腮腺炎和听力损失

• 发表时间: 2005
• 期刊: 小児内科 37
• 作者: 川島慶之;井原一成;中村美詠子;福田諭;中島務;喜多村健
• 通讯作者: 喜多村健