Evaluation of inner ear blood flow with laser speckle flowgraphy

激光散斑血流成像评估内耳血流

• 批准号: 15390515
• 负责人: NAKASHIMA Tsutomu
• 金额: $ 7.87万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390515/
• 关键词: Cochlea; Blood flow; Laser; Speckle; Schwartze sign; Otosclerosis; Venous congestion; 内耳; レーザースペックル; レーザードップラー; レーザースッペクル; 感音難聴

The cochlea is principally supplied from the inner ear artery (labyrinthine artery), which is usually a branch of the anterior inferior cerebellar artery (AICA). The human cochlea is not easily accessible for investigation because this delicate sensory organ is hidden deep in the temporal bone. However, we could measure cochlear blood flow (CBF) in patients who received cochlear implants, using a laser-Doppler probe placed over the site of drilling in the cochlear bony wall. In the patients with idiopathic progressive sensorineural hearing loss, the CBF was significantly lower in patients more than 40 years old. Intracochlear calcification following meningitis also appeared to be associated with a reduced CBF.Using lase-speckle flowgraphy, pulsation of the AICA was observed in rats, but evaluation of the CBF itself was very difficult. However, in patients with cochlear otosclerosis, blood flow to the promontory was evaluated using the laser-speckle flowgraphy. It has been reported that vascular shunts exist between the cochlea and the surrounding bone in cochlear otosclerosis. Some authors speculated that these vascular shunts might represent collateral circulation from the membraneous cochlea, which bypasses the reduced or absent capillary networks of the spiral ligament and drains into the vessels of the otosclerotic focus. In our study, patients with otosclerosis exhibited elevated and pulsating blood flow to the promontory with the Schwartze sign. The Schwartze sign correlated significantly with otosclerotic lesions invading the promontory. It is possible that blood flow inside the cochlea decreases due to the venous congestion in cochlear otosclerosis. If so, blood flow differs between the inside and outside of the cochlea in cochlear otosclerosis

耳蜗主要是从内耳动脉（迷宫动脉）提供的，该动脉通常是前小脑动脉（AICA）的分支。由于这种精致的感觉器官隐藏在颞骨深处，因此人耳蜗不容易进行调查。但是，我们可以使用在耳蜗骨壁上的钻孔部位上使用激光多普勒探针来测量接受人工耳蜗的患者的耳蜗血流（CBF）。在特发性进行性感觉神经性听力损失的患者中，40岁以上患者的CBF明显降低。脑膜炎后的钙内钙化似乎也与CBF降低有关。使用Lase螺旋流程学，在大鼠中观察到AICA的脉动，但是对CBF本身的评估非常困难。然而，在耳蜗硬膜硬化的患者中，使用激光螺旋流程学评估了流向海角的血液流动。据报道，耳蜗耳鼻喉病中的耳蜗和周围骨骼之间存在血管分流。一些作者推测，这些血管分流可能代表膜耳蜗的附带循环，该膜耳蜗绕过螺旋韧带的减少或不存在的毛细血管网络并将其排入耳粘膜焦点的血管。在我们的研究中，耳鼻喉病患者的血液流向海角的血流升高，并带有施瓦茨症状。 Schwartze符号与入侵海角的耳效性病变显着相关。由于耳蜗耳鼻喉病的静脉充血，耳蜗内部的血流可能会减少。如果是这样，血流在耳蜗耳蜗的内部和外部之间有所不同

项目成果

両側変動性感音難聴をきたした特発性低音髄圧症候群の一例

特发性低音脊髓压迫综合征伴双侧波动性感音神经性耳聋一例

• 发表时间: 2004
• 期刊: Audiol Jpn 48
• 作者: 杉浦真;橋本彩恵;曾根三千彦;中島務
• 通讯作者: 中島務

Effects of round window membrane rupture on cochlear blood flow and endcochlear potential.

圆窗膜破裂对耳蜗血流和耳蜗电位的影响。

• 发表时间: 2003
• 期刊: Nippon Jibiinnkouka Gakkai Kiho 06
• 作者: Liu X;Sone M;Tominaga M;Hayashi H;Yamamoto H;Nakashima T.
• 通讯作者: Nakashima T.

Image diagnosis of sensorineural hearing loss.

感音神经性听力损失的影像诊断。

• 发表时间: 2004
• 期刊: Practica Oto-Rhino-Laryngologica 97
• 作者: Nakashima T;Misawa H;Sone M;Kobayashi M;Sugiura M.;Nakashima T.
• 通讯作者: Nakashima T.

Treatment of inner ear through the middle ear : What have we learnt from the gentamichin approach?

通过中耳治疗内耳：我们从庆大霉素方法中学到了什么？

• 发表时间: 2004
• 期刊: Audiol Medicine 3
• 作者: Nakashima T;Misawa H;Sone M;Kobayashi M;Sugiura M
• 通讯作者: Sugiura M

流行性耳下腺炎(ムンプス)と難聴

腮腺炎和听力损失

• 发表时间: 2005
• 期刊: 小児内科 37
• 作者: 川島慶之;井原一成;中村美詠子;福田諭;中島務;喜多村健
• 通讯作者: 喜多村健