Disruption of the blood-labyrinthine barrier and related genes in sudden sensorineural hearing loss

Disruption of the blood-labyrinthine barrier was evaluated by the degree of Gd contrast enhancement of the inner ear in suddensensorineural hearing loss. There were ears with significant Gd enhancenment but there were also ears without Gd enhancement. Disruption of the blood-labyrinthine barrier may be associated with impairment of the blood vessels, inflammation and oxidative stress. The relevant gene polymorphisms were investigated in patients with sudden sensorineural hearing loss and in controls. Polymorphisms of interleukin-1A (rs1800587), interleukin-6 (rs1061170), complement factor H (rs1061170), aquaporin5 (rs3736309) and NO synthase 3 (rs1799983) seemed to be related to onset of sudden sensorineural hearing loss.交付決定額

Disruption of the blood-labyrinthine barrier was evaluated by the degree of Gd contrast enhancement of the inner ear in suddensensorineural hearing loss. There were ears with significant Gd enhancenment but there were also ears without Gd enhancement. Disruption of the blood-labyrinthine barrier may be associated with impairment of the blood vessels, inflammation and oxidative stress. The relevant gene polymorphisms were investigated in patients with sudden sensorineural hearing loss and in controls. Polymorphisms of interleukin-1A (rs1800587), interleukin-6 (rs1061170), complement factor H (rs1061170), aquaporin5 (rs3736309) and NO synthase 3 (rs1799983) seemed to be related to onset of sudden sensorineural hearing loss.交付決定額