Disruption of the blood-labyrinthine barrier and related genes in sudden sensorineural hearing loss

突发感音神经性听力损失中血迷路屏障和相关基因的破坏

• 批准号: 21390460
• 负责人: NAKASHIMA Tsutomu
• 金额: $ 9.07万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390460/
• 关键词: 突発性難聴; 血液迷路関門; MRI; 遺伝子多型; 急性低音障害型感音難聴; メニエール病; 内リンパ水腫; 血管透過性; 炎症; インターロイキン; CFH; 内耳

Disruption of the blood-labyrinthine barrier was evaluated by the degree of Gd contrast enhancement of the inner ear in suddensensorineural hearing loss. There were ears with significant Gd enhancenment but there were also ears without Gd enhancement. Disruption of the blood-labyrinthine barrier may be associated with impairment of the blood vessels, inflammation and oxidative stress. The relevant gene polymorphisms were investigated in patients with sudden sensorineural hearing loss and in controls. Polymorphisms of interleukin-1A (rs1800587), interleukin-6 (rs1061170), complement factor H (rs1061170), aquaporin5 (rs3736309) and NO synthase 3 (rs1799983) seemed to be related to onset of sudden sensorineural hearing loss.交付決定額

Disruption of the blood-labyrinthine barrier was evaluated by the degree of Gd contrast enhancement of the inner ear in suddensensorineural hearing loss. There were ears with significant Gd enhancenment but there were also ears without Gd enhancement. Disruption of the blood-labyrinthine barrier may be associated with impairment of the blood vessels, inflammation and oxidative stress. The relevant gene polymorphisms were investigated in patients with sudden sensorineural hearing loss and in controls. Polymorphisms of interleukin-1A (rs1800587), interleukin-6 (rs1061170), complement factor H (rs1061170), aquaporin5 (rs3736309) and NO synthase 3 (rs1799983) seemed to be related to onset of sudden sensory hearing loss.

项目成果

Cochlear blood flow and speech perception ability in cochlear implant users

人工耳蜗使用者的耳蜗血流和言语感知能力

• DOI: 10.1097/mao.0b013e318241c0db
• 发表时间: 2012
• 期刊: Otol Neurotol
• 影响因子: 2.1
• 作者: Nakashima T.;et al
• 通讯作者: et al

Association of interleukin-1 gene polymorphisms with sudden sensirineral hearing loss and Meniere's disease

IL-1基因多态性与突发感性听力损失和梅尼埃病的关联

• 发表时间: 2011
• 期刊: Int Journal Immunogenet
• 作者: Furuta T;Teranishi M;Uchida Y;Nishio N;Kato K;Otake H;Yoshida T;Tagaya M;Suzuki H;Sugiura M;Sone M;Hiramatsu M;Sugiura S;Ando F;Shimokata H;Nakashima T.
• 通讯作者: Nakashima T.

内リンパ水腫症例における連続周波数ティンパノメトリーとMRI画像所見の比較(第2報)

内淋巴积水病例连续频率鼓室导抗测试与 MRI 图像结果的比较（第二次报告）

• 发表时间: 2011
• 作者: 加藤健;他
• 通讯作者: 他

「紹介の最適のタイミングは?」急性難聴の鑑別とその対処

“转诊的最佳时机是什么？”

• 发表时间: 2012
• 作者: 寺西正明;中島務
• 通讯作者: 中島務

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