Interaction between perception and vocalization in cortex

皮层感知和发声之间的相互作用

• 批准号: 11470356
• 负责人: KOJIMA Hisayoshi
• 金额: $ 6.53万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470356/
• 关键词: Speech perception; Vocalization; Functional brain imaging; PET; Cochlear implant; Auditory feedback; Stuttering; Spasmodic dysphonia; 聴覚障害; 言語障害; リハビリテーション; 補足運動野

We examined central processing mechanism for speech perception and production using functional brain image such as positron emission tomography (PET) in subjects of hearing impairment and speech disorder as well as normal subjects. Postlingually deafened subjects indicated rather identical activation of auditory association areas with normal subjects. But, more activation was observed in cingulate gyrus and supplementary motor area in deaf subjects. The brain imaging of prelingually deafened subjects showed quite different pattern. Most cases showed little activation in the auditory association areas by listening to speech sounds via cochlear implant. On the other hand, the auditory association areas were activated by lipreading in some prelingually deafened subjects. In moderate sensorineural hearing impairment patients, the auditory area ipsilateral to the hearing ear was less activated. Thus, the effect of less information transmitted from the ear causes variable changes in the brai … More n. As for vocalization, Broca's area, motor area, supplementary motor area (SMA), the cerebellum were important for output-of speech. However, the auditory association areas were not activated during vocalization, which indicated that auditory feedback system was not needed to perform daily conversational vocalization. In contrast, when one's speech was distorted, the auditory association areas became to be activated, which implied the feedback system to repair vocalization. PET images of stutturers showed no auditory feedback, which should be one cause of the refractory symptom. On the other hand, spasmodic patient's SMA did not work although there was auditory feedback. Thus the diseases are manifested in various ways according to cortical functional deficit.In conclusion, we have confirmed that the interaction between perception and vocalization is remarkably important to elucidate the etiology of various communicative disorders as well as to develop the treatment for those diseases. Less

本研究采用正电子发射断层扫描（PET）等脑功能成像技术，对听力障碍和言语障碍患者以及正常人的言语感知和产生的中枢加工机制进行了研究。语后聋受试者与正常受试者的听觉关联区的激活情况相当一致。而聋组扣带回和辅助运动区激活较多。而语前水平受试者的脑成像显示出完全不同的模式。大多数病例通过人工耳蜗听语音时，听觉联合区几乎没有激活。另一方面，在某些语前水平的被试中，唇读激活了听觉联想区。中度感音神经性听力障碍患者，听力正常耳同侧听觉区激活较少。因此，从耳朵传递的信息较少的影响会导致大脑的可变变化。 ...更多信息 n.在发声方面，Broca区、运动区、辅助运动区（SMA）、小脑对语音输出起重要作用。然而，在发声过程中，听觉联想区并没有被激活，这表明日常会话发声并不需要听觉反馈系统。相反，当语音失真时，听觉联想区被激活，这意味着反馈系统对发声进行修复。口吃者的PET图像显示没有听觉反馈，这应该是难治性症状的原因之一。另一方面，痉挛患者的SMA虽然有听觉反馈，但不起作用。因此，疾病表现在不同的方式根据皮质功能缺陷。总之，我们已经证实，知觉和发声之间的相互作用是非常重要的，以阐明各种沟通障碍的病因，以及开发这些疾病的治疗。少

项目成果

児嶋久剛 他: "中枢における言葉の認知と表出の相互作用"喉頭. 12. 12-16 (2000)

Hisatake Kojima 等人：“中枢神经系统中语音识别和表达之间的相互作用”Larynx。12. 12-16 (2000)

児嶋久剛,平野滋 他: "中枢における言葉の認知と表出の相互作用."喉頭. 12. 12-16 (2000)

Hisatake Kojima、Shigeru Hirano 等人：“中枢神经系统中语音识别和表达之间的相互作用”。 12. 12-16 (2000)

Naito Y, Hirano S, Fujiki N, et al.: "Development and plasticity of the auditory cortex in cochlear implant users : A follow-up study by positron emission tomography."Adv Otorhinolaryngol. 57. 55-59 (2000)

Naito Y、Hirano S、Fujiki N 等人：“人工耳蜗使用者听觉皮层的发育和可塑性：正电子发射断层扫描的后续研究。”Adv Otorhinolaryngol。

Naito Y,Hirano S,Fujiki N,Nishizawa,Takahashi H,Kojima H, et al.: "Development and plasticity of the auditory cortex in cochlear implant users : A follow-up study by positron emission tomography."Adv Otorhinolaryngol. 57. 55-59 (2000)

Naito Y、Hirano S、Fujiki N、Nishizawa、Takahashi H、Kojima H 等人：“人工耳蜗使用者听觉皮层的发育和可塑性：正电子发射断层扫描的后续研究。”Adv Otorhinolaryngol。

Kojima H, Hirano S, Tateya I, et al.: "Interaction between perception and vocalization in central language processing."Larynx Jpn. 12. 12-16 (2000)

Kojima H、Hirano S、Tateya I 等人：“中央语言处理中感知和发声之间的相互作用。”Larynx Jpn。