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The Role of the Vocal Ligament in Vocalization

声带韧带在发声中的作用

基本信息

批准号：
10321216
负责人：
INGO R TITZE
金额：
$ 58.12万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10321216
关键词：
Address Age Attention Biological Bioreactors Birds Canis familiaris Cartilage Collagen Collagen Fiber Computer Models Crico-arytenoid joint Cricothyroid joint Deglutition Deposition Development Dose Elastin Fiber Elements Exercise Exhibits Fiber Fibroblasts Frequencies Gel Geometry Growth Factor Human In Vitro Larynx Length Lifting Ligaments Longevity Maintenance Mammals Measures Mechanical Stress Mechanics Modeling Molecular Morphology Muscle Persons Phonation Physiological Play Population Positioning Attribute Posture Primates Process Property Protocols documentation Public Health Regimen Research Role Rotation Social Interaction Specimen Speech Stress Stretching Structure Supplementation Techniques Testing Thick Thyroarytenoid Muscle Time Tissue Engineering Tissues Translations Variant Voice Voice Training Yawning aged base density design engineering design experimental study human subject ligament development macula mechanical force microscopic imaging pressure response vibration vocal cord vocalization voice therapy

项目摘要

PROJECT SUMMARY/ABSTRACT This research addresses an important public health concern, the development and maintenance of adequate pitch variation and vocal clarity throughout the life span. Evidence has been growing that vocal pitch range and stability of vocalization can be maintained with voice training and therapy techniques that rely heavily on repeated pitch glides, presumably to stretch the vocal ligament. It is impossible to measure directly the time-course of remodeling the vocal ligament with exercise in live humans. However, strong inferences can be drawn from structural and mechanical diversity across several species, from tissue engineering, and from computational modeling. In this proposal, we combine (1) microscopic imaging to test collagen density and fiber orientation in multiple species, (2) bioreactor design of a vocal ligament with combined axial and vibrational stress and selected growth factors, (3) finite-element computer modeling to predict fundamental frequency ranges and stability in vocal fold adduction, and (4) human subject exercise protocols to increase fundamental frequency range and vocal adduction control. While the aims can all be executed independently, they cross-validate each other on the basic premise that the vocal ligament is critical for fo range and can change over time. A first hypothesis is that the ligament can sustain high tension (up to 1 MPa) for high fundamental frequencies. A second hypothesis is that the vocal ligament serves as a stabilizer in vocal fold posturing and maintaining a consistently straight fold edge for glottal closure. Doses of repeated stretching are designed for engineering tissue in vitro and for human subject exercises. Results will benefit a large population of people who are vocally active but whose voices appear physiologically weak or aged.

项目总结/文摘