权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Elucidation of microcirculation mevement for establishment of vascularized bone of periosteum graft operation based on newly formed circulation

基于新生循环阐明骨膜移植手术血管化骨建立的微循环机制

基本信息

批准号：
11470374
负责人：
YONEHARA Yoshiyuki
金额：
$ 3.58万
依托单位：
Saitama Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

The condition of circulation has a direct influence on the bone formation of bone or periosteal graft. Many experimental and clinical studies have been reported that the vascularized bone or periosteal graft had strong osteogenic capacity, far superior to that of the free gone or periosteal graft. On the other hand, prefabrication provides a new method for creating donor sites which are not limited by natural vascular territories. Prefabricated flap has become a popular procedure in the case of cutaneous or musclocutaneous flap. The advantage of prefabricated flap is that flaps can be created in desired donor sites. The ability to prefabricate a flap in a preferred donor site will reduce donor site morbidity, functional deficit, and aesthetic complication. In this experimental study, we investigate the growth potential of costochondral graft, the course of osteoanageoesis of vascularized periosteal graft and the osteogenic capacity of the prefabricated vascularized periosteal graft. We … More concluded that a costochondral graft has growth potential after free heterotopic transplantation and the contact with cartilage seems to be an important factor in growth. The course of osteoanagenesis of vascularized periosteal graft was investigated using vascularized tibial and fibular periosteal grafts. Regenerated bone appeared in two weeks on X-ray films. On histological examination, mature lamellar bone was observed in four weeks. On angiographic examination, newly formed vascular network appeared in seven days after bone excision. Based on these results, we investigated vascularized prefabricated periosteal graft using tibial and fibular periosteal grafts. Two weeks after vascular bandle transfer newly formed vascular network appeared and two weeks after bone excision newly formed bone was observed. It is presumed that vascularized prefabricated periosteal grafts have promising clinical possibilities. For the bases of research of the microcirculation of prefabricated periosteal graft, we investigated microcirculation of skin and effect of medicine and magnetic field on skin blood flow. And clinical application of microvascular free flap transfer in reconstructive surgery was studied. Less

循环状态对骨或骨膜移植的成骨有直接影响。许多实验和临床研究表明，带血管蒂骨或骨膜移植具有较强的成骨能力，远优于游离或骨膜移植。另一方面，预制提供了一种新的方法来创建不受自然血管领土限制的供体部位。预制皮瓣在皮肤或肌皮瓣中已成为一种流行的手术方法。预制皮瓣的优点是可以在所需的供区形成皮瓣。在首选供区预制皮瓣的能力将减少供区发病率、功能缺陷和美容并发症。在本实验研究中，我们研究了肋软骨移植物的生长潜力、带血管蒂骨膜移植物的成骨过程以及预制的带血管骨膜移植物的成骨能力。We…More的结论是，游离异位移植后的肋软骨移植物具有生长潜力，与软骨的接触似乎是生长的重要因素。采用带血管蒂胫骨和腓骨骨膜移植，研究带血管蒂骨膜移植的成骨过程。两周后X线片上可见新生骨。组织学检查，4周内可见成熟的板层骨。血管造影显示，术后7d可见新生血管网形成。基于这些结果，我们使用胫骨和腓骨骨膜移植物研究了带血管预制骨膜移植物。血管束移植后2周可见新形成的血管网，截骨后2周可见新骨形成。推测带血管的预制骨膜移植物具有良好的临床应用前景。为进一步研究预制骨膜移植物的微循环，我们研究了皮肤微循环及药物和磁场对皮肤血流量的影响。并对微血管游离皮瓣移植在重建外科中的临床应用进行了研究。较少