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Why is the mild exercise effective for prevention and treatment of common disease?

为什么轻度运动对预防和治疗常见病有效？

基本信息

批准号：
11480014
负责人：
TANAKA Hiroaki
金额：
$ 9.22万
依托单位：
Fukuoka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

项目摘要

Based on the hypotheses that common pathological cause of type2 diabete5, hypercholesteremia, heart disease, and hypertension might be due to abnormality of function and structure in endothelial cell and skeletal muscle, we measured the parameters of the function and structure in endothelial cell and skeletal muscle by histochemical, biochemical, molecularbiological methods and investigated the effect of mild exercise training at lactate threshold on the parameters and risk factors of common disease. Obtained results are as follows. 1.A significant correlation between VO2max and basal levels of NOx was found. 2.Although we observed the existence of both the eNOS and iNOS in human skeletal muscle using histochemical method, the change in these enzymes after the training was not large enough to be detected. 3.The blood level of serum NOx did not change after a single bout of mild exercise. 4.6-wk training significantly augmented both the basal level of serum NOx and capillary density in human skeletal muscle. The changes in capillary density were related to change in blood lipid profile. 5.Eleyated basal level of NOx after 6-wk of mild training returned to the pre-training level after the long-term (12-wk) training. We also found that long-term training did not change NOx level in elderly. 6.The 6-wk training tended to increase forearm reactive hyperernia and basal IGFBP-l level, and improve insulin resistance. 7.We confirmed that the training significantly increased LT and decreased both the systolic and diastolic blood pressure in patients with hypertension. Based on these results, we conclude that mild exercise training at LT can improve the ability of endothelial-dependent vasodilation and insulin resistance in its early stages and these improvements may be associated with the risk reduction of common disease.

基于2型糖尿病、高血压、心脏病和高血压的共同病理原因可能是内皮细胞和骨骼肌功能与结构异常的假设，我们采用组织化学、生化、免疫组化、免疫组化等方法测定了内皮细胞和骨骼肌的功能与结构参数，采用分子生物学方法，探讨乳酸阈下轻度运动训练对常见疾病相关参数及危险因素的影响。获得的结果如下。2.虽然我们用组织化学方法观察到人骨骼肌中eNOS和iNOS的存在，但这些酶在训练后的变化并不明显。3.血清氮氧化物的血液水平没有改变后，一次温和的运动。4.6周的训练显着增加了基础水平的血清氮氧化物和毛细血管密度在人骨骼肌。毛细血管密度的变化与血脂谱的变化有关。5.轻度训练6周后升高的NOx基础水平在长期训练（12周）后恢复至训练前水平。我们还发现，长期训练并没有改变老年人的NOx水平。6. 6周运动训练有增加前臂反应性充血和基础IGFBP-1水平的趋势，并改善胰岛素抵抗。7.高血压病患者运动训练能显著提高LT，降低收缩压和舒张压。根据这些结果，我们得出结论，在LT温和的运动训练可以改善内皮依赖性血管舒张能力和胰岛素抵抗的早期阶段，这些改善可能与常见疾病的风险降低。