Analysis of bacterial infectious-pathogens in Japan and Asian countries.

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Salmonella Oranienburg strains which had isolated from the patient in 1999 were VNC and sensitive to NaCl osmotic stress. After the passage of these strains in mice, they became resistant to NaCl osmotic stress. VNC Salmonella Oranienburg would be potentially dangerous contaminants of NaCl-preserved foods. VNC Salmonella showed high pathogenicity to morphine-treated mice. The morphine-treated mouse is the good bioassay model for VNC Salmonella.We investigated the secretion of STEC from the sheep for 15 months. Once a sheep had STEC, it maintained STEC and secreted it for a long time. A sheep might be important as a reservoir of STEC.We found the homologue of the B-subunit of Cholera toxin and E. coli LT toxin in Citrobacter freundii and determined the sequence of the gene.We constructed the highly sensitive bead-ELISA system for Helicovacter pylori VacA and succeeded to detect VacA directly in the gastric juice of the gastric ulcer patients.The mice deficient in RPTP β do not show mucosal damage by VacA of Helicobacter pylori. This result indicates that erroneous RPTP β signaling induced gastric ulcers.