Development of Supramolecular Complex Sensor Possessing Biological Recognition Function
具有生物识别功能的超分子复合传感器的研制
基本信息
- 批准号:14340230
- 负责人:
- 金额:$ 9.54万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2002
- 资助国家:日本
- 起止时间:2002 至 2003
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this study, novel supramolecular complex sensors for ion and molecule recognition in water have been designed. The boronic acid flouoroionophore/β-CyD complex binds sugars and produces increased fluorescence emission in Water. To evaluate the structural effect, three different boronic acid fluoroionophores in which the boronic acid recognition site and the pyrene fluorophore are conjugated with different length of ester spacer (Cn-PB) or amide spacer (Cn-APB) are designed. Based on the fluorescence emission mechanism (the suppression of PET from pyrene donor to trigonal phenylboronic acid acceptor), the highest response efficiency and selectivity obtained for C1-APB. For selective Pb^<2+> recognition, a podand structure possessing pseudo-18-crown-6 structure that can stabilize Pb^<2+> chelate complexes while reducing the interaction with alkali metal cations is utilized. Thus the podand fluoroionophore (PD-1)/γ-Cyclodextrin (γ-CyD) complex sensor exhibits markedly high selectivity for Pb^<2+> ion in water. The response mechanism is based upon the dimerization of the fluoroionophore inside the γ-CyD, thereby resulting in a Pb^<2+>-selective pyrene dimer emission. The micellar solution is expected to provide a hydrophobic microenvironment that solubilizes the lipophilic fluoroionophore in water and enhances the ionophore/metal interaction. However below the critical micelle concentration (CMC) of Triton X-100, the podand fluoroionophore (DAC-1)/Triton X-100 complex is found to exhibit sit amplified fluorescence response for Pb^<2+> in water. Dynamic light scattering and dark-field microscope analyses reveal that the DAC-1/Triton X-100 complex forms micron-size aggregates triggered by selective Pb^<2+> binding, resulting in the enhancement of fluorescence intensity with a distinct blue shift of the fluorescence emission. This is a novel supramolecular function of the DAC-1/Triton X-100 complex sensor for selective Pb^<2+> recognition in water.
本研究设计了一种新型的超分子配合物传感器,用于水中离子和分子的识别。硼酸荧光离子载体/β-CyD复合物结合糖并在水中产生增加的荧光发射。为了评估结构效应,设计了三种不同的硼酸荧光离子团,其中硼酸识别位点和芘荧光团与不同长度的酯间隔基(Cn-PB)或酰胺间隔基(Cn-APB)缀合。基于荧光发射机理(PET从芘供体到三角苯基硼酸受体的抑制),C1-APB获得了最高的响应效率和选择性。为了选择性地识别Pb^2+,利用了具有伪18-冠-6结构的荚状结构,其可以稳定Pb^2+螯合物,同时减少与碱金属阳离子的相互作用。因此,该复合传感器对水中Pb^2+离子具有很高的选择性。响应机制是基于γ-CyD内的荧光离子载体的二聚化,从而导致Pb^<2+>-选择性芘二聚体发射。预计胶束溶液将提供疏水性微环境,使亲脂性荧光离子载体溶解在水中并增强离子载体/金属相互作用。在低于TritonX-100的临界胶束浓度(CMC)时,POD-1/TritonX-100复合物对水中Pb^2+的荧光响应出现放大。动态光散射和暗视野显微镜分析表明,DAC-1/Triton X-100复合物在Pb^2+选择性结合的触发下形成微米级聚集体,导致荧光强度增强,荧光发射明显蓝移。这是DAC-1/Triton X-100复合传感器选择性识别水中Pb^2+的一种新的超分子功能。
项目成果
期刊论文数量(64)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
早下隆士(分担執筆): "「超分子科学-ナノ材料創製にむけて」 9章"化学同人. 93-102 (2004)
Takashi Hayashita(合著者):“‘超分子科学 - 迈向纳米材料的创造’第 9 章”化学同人志 93-102 (2004)。
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T.Hayashita, Q.Dai, J.C.Lee, C.N.Teramae: "Highly Selective Recognition of Lead Ion in Water by Podand Fluoroignophore/γ-Cyclodextrin Complex Sensor"Chem.Commun. 2160-2161 (2003)
T.Hayashita、Q.Dai、J.C.Lee、C.N.Teramae:“Podand 荧光团/γ-环糊精复合传感器对水中铅离子的高度选择性识别”Chem.Commun. 2160-2161 (2003)
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A.Yamauchi, T.Hayashita, A.Kato, N.Teramae: "Supramolecular Crown Ether Probe/γ-Cyclodextrin Complex Sensors for Alkali Metal Ion Recognition in Water"Bull. Chem. Soc. Jpn.. 75. 1527-1532 (2002)
A.Yamauchi、T.Hayashita、A.Kato、N.Teramae:“用于水中碱金属离子识别的超分子冠醚探针/γ-环糊精复合物传感器”Bull Jpn.. 75。 1527-1532 2002)
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T.Hayashita, Dai Qing, N.Teramae, S.Y.Moon, S.-K.Chang: "Design and Function of Proton-Ionizable Cyclam Fluoroionophore for Zinc(II) Ion Sensing in Water"J.Ion Exch.. 14. 337-340 (2003)
T.Hayashita、戴青、N.Teramae、S.Y.Moon、S.-K.Chang:“质子电离 Cyclam 氟离子载体用于水中锌 (II) 离子传感的设计和功能”J.Ion Exch.. 14. 337
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- 影响因子:0
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R.Hayshi, T.Hayashita, T.Yoshikawa, K.Hiratani, R.A.Bartsch, N.Teramae: "Design of Polymer Inclusion Membrane Having Proton-ionizable Polyether Carriers and Their Separation Function for Lead Ion"Bunseki Kagaku. 52(9). 755-762 (2003)
R.Hayshi、T.Hayashita、T.Yoshikawa、K.Hiratani、R.A.Bartsch、N.Teramae:“具有质子电离聚醚载体的聚合物包合膜的设计及其对铅离子的分离功能”文石化学。
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HAYASHITA Takashi其他文献
Design of Saccharide Recognition Material Based on Boronic Acid Fluorophore/Cyclodextrin Gel
基于硼酸荧光团/环糊精凝胶的糖类识别材料的设计
- DOI:
10.5182/jaie.29.126 - 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
SOMA Suzuka;SUZUKI Takahito;G. BEKELE Tewodros;TSUCHIDO Yuji;HASHIMOTO Takeshi;HAYASHITA Takashi - 通讯作者:
HAYASHITA Takashi
Fluorescence Detection of Endotoxin Using Cadmium Complexed with Dipicolylamine-type Pyrene Probe
镉与二吡啶胺型芘探针络合荧光检测内毒素
- DOI:
10.5182/jaie.33.95 - 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
KIMOTO Hiroshi;IIYAMA Masamitsu;HASHIMOTO Takeshi;HAYASHITA Takashi - 通讯作者:
HAYASHITA Takashi
Synthesis and Self-Assembly of Oligosaccharide-Based Block Copolymers
低聚糖基嵌段共聚物的合成与自组装
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
KITAMURA Aya;KASAI Yuna;TSUCHIDO Yuji;HASHIMOTO Takeshi;HAYASHITA Takashi;磯野拓也 - 通讯作者:
磯野拓也
Effect of Spacer Length in Pyrene-Modified-Phenylboronic Acid Probe/CyD Complexes on Fluorescence-based Recognition of Monosaccharides in Aqueous Solution
芘修饰苯硼酸探针/CyD 配合物中间隔基长度对水溶液中单糖荧光识别的影响
- DOI:
10.2116/analsci.20scp08 - 发表时间:
2021 - 期刊:
- 影响因子:1.6
- 作者:
TSUCHIDO Yuji;KOJIMA Shohei;SUGITA Ko;FUJIWARA Shoji;HASHIMOTO Takeshi;HAYASHITA Takashi - 通讯作者:
HAYASHITA Takashi
分子認識プローブ修飾ナノ粒子を用いた細菌検出法の開発
使用分子识别探针修饰纳米粒子开发细菌检测方法
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
KITAMURA Aya;KASAI Yuna;TSUCHIDO Yuji;HASHIMOTO Takeshi;HAYASHITA Takashi;磯野拓也;土戸優志 - 通讯作者:
土戸優志
HAYASHITA Takashi的其他文献
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{{ truncateString('HAYASHITA Takashi', 18)}}的其他基金
Development of novel molecular recognition surface based on dendrimers
基于树枝状聚合物的新型分子识别表面的开发
- 批准号:
24655069 - 财政年份:2012
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of Chromogenic Probe/Dendrimer Complexes for Molecular Discrimination
用于分子辨别的显色探针/树枝状聚合物复合物的开发
- 批准号:
21655030 - 财政年份:2009
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of Molecular Imprinting Sensors Poccessing Sugar Recognition Function
具有糖识别功能的分子印迹传感器的开发
- 批准号:
18350043 - 财政年份:2006
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Design of Supramolecular Cyclodextrin Complex Sensors and Construction of Functional Interfaces
超分子环糊精复合传感器的设计及功能接口的构建
- 批准号:
16550066 - 财政年份:2004
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Design and Function of Molecular Complex Sensors Based on Supramolecular Structure
基于超分子结构的分子复合传感器的设计与功能
- 批准号:
12440208 - 财政年份:2000
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Design of Artificial Cell Membrane Interface and Development of Evaluation System for Biorecognition Function
人工细胞膜界面设计及生物识别功能评价系统开发
- 批准号:
12554029 - 财政年份:2000
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular Design of Alkali Metal Ion Probes for Use in Aqueous Media
用于水介质的碱金属离子探针的分子设计
- 批准号:
09650893 - 财政年份:1997
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
DEVELOPMENT OF NOVEL, POLYETHER CHELATING RESINS FOR USE IN SELECTIVE LEAD (II) SEPARATION
开发用于选择性铅 (II) 分离的新型聚醚螯合树脂
- 批准号:
07555265 - 财政年份:1995
- 资助金额:
$ 9.54万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
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