Applied Clinical Study on Hyperpolarized Noble Gas MRI/MRS using Pathologic Model Animal

超极化惰性气体MRI/MRS病理模型动物应用临床研究

• 批准号: 14370277
• 负责人: FUJIWARA Hideaki
• 金额: $ 8.96万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370277/
• 关键词: Hyperpolarized Noble Gas; Xe NMR; MRI; MRS; Mouse; Brain Function; Lung Function; 肺画像; 肺機能評価; 生体温度測定; エマルジョン

Home-built polarizing apparatus has been modified to supply continuous flow of Xe gas polarized to 3-5%. The polarized Xe gas was applied to mice under anesthesia and spontaneous respiration, and MRI and MRS measurements were performed with lung and brain. The results are summarized as follows :1.In the Xe-129 MRS experiments with mice lungs, diffusion of Xe spins backward from the dissolved state in lung tissue to alveolar gas state was found to affect the slope in washout curve. The true slope of the washout curve was measured by removing this effect by saturating the dissolved spins.2.The factors affecting the slope of the washout curve was separated into three terms, which afforded pulse angle, ventilation volume, and apparent relaxation time. The separation of the true relaxation term and the perfusion term is now underway.3.Precise analysis of the washout curve in mouse brain was performed and the value of true relaxation time in brain tissue was obtained.4.The slope in the lung washout curve was analyzed with the VILI(Ventilator Induced Lung Injury) mice. The slope was found to be retarded with the VILI mice compared with the healthy ones, suggesting slow ventilation in the pathologic lungs.

对自制的偏振光装置进行了改进，使其能连续提供3-5%偏振光的Xe气体。在小鼠麻醉和自主呼吸状态下，应用偏振光Xe气体，对小鼠肺和脑进行MRI和MRS测量。研究结果总结如下：1。在小鼠肺Xe-129 MRS实验中，发现Xe自旋从肺组织溶解状态向肺泡气体状态反向扩散影响冲洗曲线的斜率。通过使溶解的旋轴饱和来消除这种影响，从而测量出冲刷曲线的真实斜率。将影响冲洗曲线斜率的因素分为脉冲角、通风量和表观松弛时间三个方面。真正的松弛项和灌注项的分离正在进行中。对小鼠脑组织水洗曲线进行精确分析，得到脑组织真正的松弛时间值。用呼吸机诱导肺损伤（VILI）小鼠分析肺冲洗曲线的斜率。与健康小鼠相比，VILI小鼠的肺斜率变慢，提示病理性肺通气缓慢。

项目成果

Improvement of T1 Determination of Hyperpolarized 129Xe in Mouse Brain under Controlled-

受控条件下小鼠脑超极化 129Xe T1 测定的改进

• 发表时间: 2004
• 期刊: International Congress Series 1265
• 作者: A.Kimura;T.Wakayama;M.Narazaki;Y.Kawata;T.Ueyama;H.Fujiwara
• 通讯作者: H.Fujiwara

19F Magnetic resonance imaging of perfluorooctanoic acid encapsulated in liposome for biodistribution measurement

• DOI: 10.1016/j.mri.2004.01.060
• 发表时间: 2004-07-01
• 期刊: MAGNETIC RESONANCE IMAGING
• 影响因子: 2.5
• 作者: Kimura, A;Narazaki, M;Fujiwara, H
• 通讯作者: Fujiwara, H

Hyperpolarized 129Xe as a novel probe agent of lung functions in MRI and MRS. Experimental results with mice at 9.4 T

超极化 129Xe 作为 MRI 和 MRS 中肺功能的新型探针剂。

• DOI: 10.1016/j.ics.2004.04.028
• 发表时间: 2004
• 作者: H. Fujiwara;A. Kimura;T. Wakayama
• 通讯作者: T. Wakayama

Quantitation in Biomedical Imaging with PET and MRI, ICS1265.

PET 和 MRI 生物医学成像定量，ICS1265。

• 发表时间: 2004
• 作者: H.Fujiwara;A.Kimura;T.Wakayama
• 通讯作者: T.Wakayama

Practical application of NMR spectra of 129Xe dissolved in red blood cell

红细胞中溶解的 129Xe 核磁共振谱的实际应用

• 发表时间: 2004
• 作者: Y. Kawata;T. Kamiya;H. Miura;A. Kimura;H. Fujiwara
• 通讯作者: H. Fujiwara