A comparative genomics approach to understanding host-endosymbiont interactions

理解宿主-内共生体相互作用的比较基因组学方法

• 批准号: DP0557987
• 负责人: Prof Scott O'Neill
• 金额: $ 23.59万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-06-23 至 2008-06-22
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557987
• 关键词: comparative; genomics; approach; understanding; host

Australia's unique ecosystems are vulnerable to invasion by exotic pests that threaten agriculture and human health. The bacterial symbiont Wolbachia is found in many major pests of agricultural and medical importance. Our results will give insights into how Wolbachia spreads into host populations and improve its use as a tool to impair insect transmission of disease, e.g. as an agent to carry genes into an insect population that limit disease transmission. Our results will also make fundamental contributions to understanding host-parasite evolution, host-parasite communication, and insect developmental processes, and will be of interest to a large international community of researchers in this field.

澳大利亚独特的生态系统很容易受到外来害虫的入侵，威胁农业和人类健康。共生细菌Wolbachia存在于许多农业和医学重要害虫中。我们的研究结果将深入了解沃尔巴克氏体如何传播到宿主种群中，并改善其作为削弱昆虫传播疾病的工具的用途，例如作为将基因携带到昆虫种群中以限制疾病传播的试剂。我们的研究结果还将为理解宿主-寄生虫进化、宿主-寄生虫通信和昆虫发育过程做出根本性贡献，并将引起该领域大量国际研究人员的兴趣。