Insect host/vector genetic responses to rhabdovirus infection

昆虫宿主/载体对弹状病毒感染的遗传反应

• 批准号: LX0452397
• 负责人: Prof Scott O'Neill
• 金额: $ 2.61万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0452397
• 关键词: Insect; host; vector; genetic; responses

Rhabdoviruses cause important diseases in humans, animals and plants. These viruses are transmitted by insect vectors in which they persist and propagate, an intimate and specific association. Insect-rhabdovirus interactions will be studied at the molecular level using a planthopper-maize rhabdovirus model. Insect genes specifically induced by rhabdovirus infection as well as the viral genes themselves will be identified and characterized using genomics and bioinformatics tools. We will extend the same approaches to a comparative analysis of these planthopper genes with other insect-rhabdovirus systems under investigation in our institutes. Identification of viral genes expressed in insects, the insect genes that respond to virus infection, and interpretation of the roles of these genes in insects, may indicate new opportunities to control serious plant and animal diseases through control of virus transmission.

弹状病毒在人类、动物和植物中引起重要疾病。这些病毒通过昆虫媒介传播，并在其中持续和繁殖，这是一种密切和特定的联系。昆虫-弹状病毒的相互作用将在分子水平上使用稻飞虱-玉米弹状病毒模型进行研究。昆虫基因特异性诱导的弹状病毒感染以及病毒基因本身将被确定和特点，使用基因组学和生物信息学工具。我们将扩展相同的方法，这些稻飞虱基因的比较分析与其他昆虫弹状病毒系统正在调查中，我们的研究所。鉴定昆虫中表达的病毒基因，即对病毒感染有反应的昆虫基因，并解释这些基因在昆虫中的作用，可能预示着通过控制病毒传播来控制严重的植物和动物疾病的新机会。