Clinical evaluation and basic research for long term use of a newly developed miniature mixed-flow pump

新型微型混流泵长期使用的临床评价及基础研究

• 批准号: 14370414
• 负责人: HADAMA Tetsuo
• 金额: $ 3.71万
• 依托单位: OITA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370414/
• 关键词: Cardiopulmonary bypass; Continuous flow; Mixed-flow pump; Mixed-flow.pump

We performed a clinical evaluation and a basic research for long term use of a newly developed miniature mixed-flow blood pump (MFP) for cardiopulmonary bypass (CPB). In the clinical evaluation, 10 patients received a CPB with the MFP. The pump flow was maintained steadily. The MFP was controlled very smoothly at starting and weaning state. Changes in plasma free hemoglobin, lactate dehydrogenase, platelet count, β-thromboglobulin and thrombin-antithrombin complex showed no significant differences from those of a control pump. We believe the MFP had good controllability and less damage on the blood. Left ventricular bypasses were established in 7 goats to evaluate durability and antithrombogenesity. In two goats, experiments were finished after 14 days bypass. Thrombus formations were obtained around a bearing. We believe some improvements of bearings for long term use.

我们对一种新开发的用于体外循环(CPB)的微型混流血泵(MFP)的长期使用进行了临床评估和基础研究。在临床评估中，10名患者接受了带有MFP的体外循环。泵的流量保持稳定。在开始和断奶状态下，MFP控制非常顺利。血浆游离血红蛋白、乳酸脱氢酶、血小板计数、β-血栓球蛋白和凝血酶-抗凝血酶复合体的变化与对照泵无显著差异。我们认为MFP具有良好的可控性，对血液的损害较小。在7只山羊中建立了左心室旁路，以评估耐久性和抗血栓形成能力。在两只山羊中，实验在转流14天后完成。轴承周围有血栓形成。我们相信轴承的一些改进是为了长期使用。