Effect of calcitonin gene-related peptide (CGRP) on testicular descent in grnitofemoral nerve divided rats.

降钙素基因相关肽（CGRP）对股神经分裂大鼠睾丸下降的影响。

• 批准号: 09671832
• 负责人: SHONO Takeshi
• 金额: $ 2.05万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671832/
• 关键词: cryptorchidism; rat; calcitonin gene-related peptide; genitofemoral nerve; カルチトニン遺伝子関連ペプチド

Testicular descent was inhibited in rats which were performed the division of genitofemoral nerve (GEN) n neonatal period. At 60-90 days old, cryptorchidism was occurred in about 76% in rats which were performed the division of genitofemoral nerve in neonatal period, However, the occurrence of cryptorchidism was significantly decreased in 30-days-old rats which were first performed neonatal GFN division and 20mu gof CGRP was injected subcutaneously in hemiscrotum on operated side from 3to 14 days old. CGRP has been known one of neuropeptide and is released from the terminal of the GFN to mediated the inguinoscrotal testicular descent.These results suggested that the CGRP might be important peptide to induce normal testicular descent and might be used as effective regimen for the cryptorchidism.

新生期生殖股神经（GEN）切断可抑制大鼠睾丸下降。新生期行生殖股神经切断术的大鼠在60-90日龄时隐睾发生率约为76%，而30日龄行新生GFN切断术的大鼠在30 ~ 14日龄时隐睾发生率明显降低，在30 ~ 14日龄时于术侧阴囊皮下注射CGRP 20 μ g。CGRP是已知的神经肽之一，从GFN末端释放，介导睾丸下降，提示CGRP可能是诱导睾丸正常下降的重要肽，可作为治疗隐睾症的有效药物。

项目成果

Shono T, Zakaria O, Imajima T, Suita S, Morimoto K: "Pubertal genitofemoral nerve division induces testicular ascent in adult rats."J Pediatr Surg. 34(2). 346-348 (1999)

Shono T、Zakaria O、Imajima T、Suita S、Morimoto K：“青春期生殖股神经分裂诱导成年大鼠睾丸上升。”J Pediatr Surg。

Imajima T,Shono T,et al: "Prenatal phthalate causes cryptorchidism postnatally by inducing the transabdominal ascent of the testis in fetal rats." J Pediatr Surg. 32. 18-21 (1997)

Imajima T、Shono T 等人：“产前邻苯二甲酸盐通过诱导胎鼠睾丸经腹上升，导致产后隐睾。”

Shono T,et al: "Proceeding of the Ninth Fukuoka International Symposium on Perinatal Medicine" Maternity and Perinatal Care Unit,Kyushu University Hospital, 87 (1998)

Shono T,et al：“第九届福冈国际围产期医学研讨会论文集”九州大学医院产科和围产期护理室，87（1998）

Zakaria O,Shono T,Imajima T,Suita: "Fertility and histological studies in a unilateral cryptorchid rat model during early and late adulthood" Br j Urol. 82. 404-407 (1998)

Zakaria O、Shono T、Imajima T、Suita：“成年早期和晚期单侧隐睾大鼠模型的生育力和组织学研究”Br j Urol。

Shono T,et al: "Extra-abdominal fixation of the gubernaculum inhibits testicular descent in newborn rats." J Pediatr Surg. 31. 503-506 (1996)

Shono T 等人：“引带的腹外固定可抑制新生大鼠的睾丸下降。”