Evaluation of testicular function in the experimental models of cryptorchidism and its new treatment.

在激素诱导和机械诱导的两种不同的隐睾症大鼠模型上，进行了睾丸的组织发育和生育能力的研究。激素性隐睾症通过产前注射抗雄激素造成：氟他胺通过腹外固定新生大鼠引带造成机械性隐睾症。90日龄时，机械性隐睾性成熟大鼠的父亲率为83%(n=12)，而激素性隐睾性成熟大鼠的父亲率为0%(n=10)。Johnsen评分还表明，激素诱导的隐睾症与机械诱导的隐睾症相比，其睾丸的组织学发育受到明显的抑制。此外，与机械诱导的隐睾症相比，激素诱导的隐睾症的父亲率结果也受到了显著的抑制。这些结果表明，胎儿期诱发隐睾症的原因不仅影响出生后的睾丸发育，而且还影响这些大鼠的睾丸固定。

Histological development of the testis and fertility studies were performed in two different cryptorchid rat models which were hormonally-induced and mechanically induced cryptorchidism. Hormonally-induced cryptorchidism was made by prenatal administration of antiandrogen : flutamide and mechanically induced cryptorchidism was made by extraabdominal fixation of gubernaculum in newborn rats. At the age of 90 days, the paternity rate of sexually matured rats showed 83% (n=12) in mechanically induced unilateral cryptorchidism, in contrats the paternity rate was 0% (n=10) in hormonally induced unilateral cryptorchid rats. Johnsen score also expressed the significantly inhibited histological development of the testis in hormonally induced cryptorchidism compared by mechanically induced cryptorchidism.After orchiopesy, furthermore, the results of paternity rate was significantly inhibited in hormonally induced cryptorchidism compared by mechanically induced cryptorchidism.These results suggested that the causes which induce cryptochidism in fetal period would affect not only the postnatal testicular development but also effect the orchiopexy of these rats.