A defense mechanism of a living body in the odontoblastic complex via gap junction

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In our series of studies, we electrophysiologically obtained the function of odontoblasts and a direct, non-neural transduction mechanism between odontoblasts and between odontoblasts and neighboring cells. We recognized dentinal tubules as that have a close relation with odontoblasts as the pathway for several stimuli, and focused on the defense mechanism of outward flow of dentinal fluid, microcirculation of dental pulp and chronic dental pain.We revealed1.Dye coupling using low molecule dye2.Rack of evidence that there were voltage dependent currents in feline odontoblasts3.Defense mechanism of the outward flow against the LPS entry through dentinal tubules of intact and caries affected dentin4.Evidence of a functional syncytium of odontoblast complex5.Effect of aging on electrical conductance between odontoblasts6.Effect of extracellular pH on electrical conductance between odontoblasts7.Effect of mechanical distortion of odontoblast cell membrane electrical conductance between odontoblast8.Application of whole-cell voltage-clamp method to feline odontoblast9.Gap junction between human odontoblasts and neighboring cells10.Effect of iontophoresis and pulpward hydrostatic pressure on drug delivery through dentinal tubules 111.Effect of pulpal components on dentin permeability12.Changes in human sensation and neural activity with aging13.Neuropathic orofacial pain evoked by cold stimulus of oral mucosa14.Microcirculation in the dental pulp