Research of sudden infant death induced by abnormal lipid metabolism.

本研究旨在阐明肉碱缺乏症是婴儿猝死综合征（SIDS）的重要因素之一的脂质代谢异常，并探讨未来医学信息的途径，我们对日本及欧洲和大洋洲一些国家的年轻人进行了SIDS认知调查。1)建立了酶法测定总肉碱和游离肉碱含量的方法，并采用LC-MS/MS进行定量分析。2)水溶性维生素维生素C在肉毒碱生物合成过程中的作用。3)肉碱样物质诱导的肉碱缺乏对细胞损伤和凋亡的影响。4)如何向人们，特别是年轻一代传递医疗信息，通过调查小岛屿发展中国家对日本和欧洲和大洋洲地区其他一些国家年轻人的认识。

This study was designed to elucidate the abnormal lipid metabolism on carnitine deficiency said to be one of the important factor of sudden infant death syndrome (SIDS), and to investigate the way of medical information in the future, we carried out the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania.Following new information were obtained :1)Establishment of the method to determine the quantity of total- and free-carinitine by enzyme assay, and quantitative analysis by LC-MS/MS.2)About the role of water soluble vitamin, vitamin C, on the way of biosynthesis of carnitine.3)Effect of carnitine deficiency induced by carnitine-like-materials on cell damage and apoptosis.4)The way how to transmit of medical information to people, especially young generation, by the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania areas.