Research of sudden infant death induced by abnormal lipid metabolism.

为阐明肉碱缺乏症的脂代谢异常是婴幼儿猝死综合征的重要因素之一，为探索今后的医学信息传播途径，我们对日本及欧洲和大洋洲一些国家的青少年进行了对肉碱缺乏症知晓率的调查，获得了以下新的信息：1)建立了测定肉碱缺乏症总和游离肉碱含量的方法，并用LC-MS/MS定量分析了水溶性维生素、维生素C、维生素C和维生素C的作用。肉碱的生物合成途径。3)肉碱类物质引起的肉碱缺乏对细胞损伤和凋亡的影响。4)如何向人们，特别是年轻一代传递医学信息。通过对日本等欧洲和大洋洲地区一些国家年轻人的小岛屿发展中国家知晓率的调查。

This study was designed to elucidate the abnormal lipid metabolism on carnitine deficiency said to be one of the important factor of sudden infant death syndrome (SIDS), and to investigate the way of medical information in the future, we carried out the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania.Following new information were obtained :1)Establishment of the method to determine the quantity of total- and free-carinitine by enzyme assay, and quantitative analysis by LC-MS/MS.2)About the role of water soluble vitamin, vitamin C, on the way of biosynthesis of carnitine.3)Effect of carnitine deficiency induced by carnitine-like-materials on cell damage and apoptosis.4)The way how to transmit of medical information to people, especially young generation, by the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania areas.