Research of sudden infant death induced by abnormal lipid metabolism.

本研究旨在阐明肉毒碱缺乏引起的脂质代谢异常是婴儿猝死综合征（SIDS）的重要因素之一，并探讨未来的医疗信息途径，我们对日本以及欧洲和大洋洲的一些国家的年轻人进行了SIDS意识调查，获得了以下新信息：1）建立了酶法测定和LC-MS/MS定量分析的方法。3）肉毒碱样物质引起的肉毒碱缺乏对细胞损伤和凋亡的影响4）医学信息如何传递给人们，特别是年轻一代，通过对日本以及欧洲和大洋洲地区其他一些国家的年轻人对小岛屿发展中国家认识的调查，

This study was designed to elucidate the abnormal lipid metabolism on carnitine deficiency said to be one of the important factor of sudden infant death syndrome (SIDS), and to investigate the way of medical information in the future, we carried out the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania.Following new information were obtained :1)Establishment of the method to determine the quantity of total- and free-carinitine by enzyme assay, and quantitative analysis by LC-MS/MS.2)About the role of water soluble vitamin, vitamin C, on the way of biosynthesis of carnitine.3)Effect of carnitine deficiency induced by carnitine-like-materials on cell damage and apoptosis.4)The way how to transmit of medical information to people, especially young generation, by the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania areas.