Research of sudden infant death induced by abnormal lipid metabolism.

脂质代谢异常所致婴儿猝死的研究.

• 批准号: 15390213
• 负责人: UENO Yasuhiro
• 金额: $ 8.64万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390213/
• 关键词: sudden infant death; lipid metabolism; carnitine; vitamin C; 脂質代謝異常; 酸化ストレス

This study was designed to elucidate the abnormal lipid metabolism on carnitine deficiency said to be one of the important factor of sudden infant death syndrome (SIDS), and to investigate the way of medical information in the future, we carried out the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania.Following new information were obtained :1)Establishment of the method to determine the quantity of total- and free-carinitine by enzyme assay, and quantitative analysis by LC-MS/MS.2)About the role of water soluble vitamin, vitamin C, on the way of biosynthesis of carnitine.3)Effect of carnitine deficiency induced by carnitine-like-materials on cell damage and apoptosis.4)The way how to transmit of medical information to people, especially young generation, by the survey of SIDS awareness on young people in Japan and some other countries from Europe and Oceania areas.

本研究旨在阐明肉毒碱缺乏引起的脂质代谢异常是婴儿猝死综合征（SIDS）的重要因素之一，并探讨未来的医疗信息途径，我们对日本以及欧洲和大洋洲的一些国家的年轻人进行了SIDS意识调查，获得了以下新信息：1）建立了酶法测定和LC-MS/MS定量分析的方法。3）肉毒碱样物质引起的肉毒碱缺乏对细胞损伤和凋亡的影响4）医学信息如何传递给人们，特别是年轻一代，通过对日本以及欧洲和大洋洲地区其他一些国家的年轻人对小岛屿发展中国家认识的调查，

项目成果

M.Kodera: "Mechanism for aerobic oxidation of 3,5-di-tert-butylcatechol to 3,5-di-tert-butyl-o-benzoquinone catalyzed by di-m-hydroxo-dicopper (II) complexes of peralkylated ethylenediamine ligands"Bull.Chem.Soc.Jpn. 76. 1957-1964 (2003)

M.Kodera：“全烷基化乙二胺配体的二间羟基二铜 (II) 配合物催化 3,5-二叔丁基儿茶酚有氧氧化为 3,5-二叔丁基邻苯醌的机制

Change in liver and plasma ceramides during D-galactosamine-induced acute hepatic injury by LC-MS/MS

• DOI: 10.1016/j.bmcl.2004.05.046
• 发表时间: 2004-08-02
• 期刊: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
• 影响因子: 2.7
• 作者: Yamaguchi, M;Miyashita, Y;Kojo, S
• 通讯作者: Kojo, S

Effect of rooibos tea (Aspalathus linearis) extract on lipid peroxidation in vitamin E deficient rats.

路易波士茶（Aspalathus Linearis）提取物对维生素 E 缺乏大鼠脂质过氧化的影响。

• 发表时间: 2004
• 期刊: ITE Lett. 5
• 作者: Yamagishi H;Yoshiyama M.;Shirai N.;Akioka K;Takeuchi K;Yoshikawa J;Ryoji Yanai;E.Hitomi
• 通讯作者: E.Hitomi

岡本 摩耶: "カルニチン-機能と展望"ビタミン. 第77巻第5, 6号. 321-323 (2003)

Maya Okamoto：“肉碱 - 功能和前景”维生素。第 77 卷，第 5 期，6. 321-323 (2003)

Effects of seasonings on the stability of ascorbic acid in a cooking model system.

烹饪模型系统中调味料对抗坏血酸稳定性的影响。

• 发表时间: 2004
• 期刊: J. Nutr. Sci. Vitaminol. 50
• 作者: 田巻弘之;我妻 玲;春日規克;竹倉宏明;E.Kishida
• 通讯作者: E.Kishida