Serotonin transporter loss and psychotic state in methamphetamine users

甲基苯丙胺使用者的血清素转运蛋白丢失和精神病状态

• 批准号: 15390349
• 负责人: MINABE Yoshio
• 金额: $ 4.86万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390349/
• 关键词: methamphetamine; serotonin transpoter; aggression; PET; proton MRS; toluene; human

Background : In animals, methamphetamine is known to have a neurotaxic effect on seroronin neurons, which have been implicated in the regulation of mood, anxiety, and aggression. However, it remains unknown whether or not methamphetamine damages serotonin neurons in humans.Objective : To investigate the status of brain serotonin neurons and their possible relationship with clinical characteristics in currently abstinent former methamphetamine abusers.Desigh : The brain regional density of the serotonin transporter, a structural component of serotonin neurons, was estimated in the brain using positron emission tomography (PET) and [^<11>C](+)McN-5652. A case-control analysis was performed with the estimates derived from region-of-interest (ROI) and statistical parametric mapping (SPM) methods, followed by within-case analysis with the measures of clinical variables.Setting : Partieipants were recruited from the community to a hospital research center.Participants : Twelve currently abst … More inent former methamphetamine abusers (5 women, 7 men) and age-, gender-, and twelve education-matched healthy control subjects (5 women, 7 men).Main Outcome Measures : The duration of methamphetamine use, magnitude of aggression and depressive symptoms, and changes in serotonin transporter density represented by the [^<11>C](+)McN-5652 distribution volume.Results : The methamphetamine abusers showed increased levels of aggression compared to those of the control subjects. Both ROI and SPM analyses revealed that the serotonin transporter density in global brain regions (eg, midbrain, thalamus, caudate, putamen, cerebral cortex, and cerebellum) was significantly lower in the methamphetamine abusers than in the control subjects, and this reduction was found to be significantly inversely correlated with the duration of methamphetamine use. Furthermore, SPM analyses indicated that the density in the orbitofrontal, temporal, and anterior cingulate areas was closely associated with the magnitude of aggression in methamphetamine abusers.Conclusions : Protracted abuse of methamphetamine may reduce the density of the serotonin transporter in the brain, leading to elevated aggression, even among those in a currently abstinent state. Less

背景：在动物中，已知甲基苯丙胺对血清素神经元具有神经定向作用，而血清素神经元与情绪、焦虑和攻击性的调节有关。然而，甲基苯丙胺是否会损害人类血清素神经元仍不清楚。目的：研究目前戒毒的前甲基苯丙胺滥用者大脑血清素神经元的状态及其与临床特征的可能关系。设计：使用正电子发射断层扫描估计大脑中血清素转运蛋白（血清素神经元的结构成分）的大脑区域密度 (PET)和[^ 11 C](+)McN-5652。使用来自感兴趣区域 (ROI) 和统计参数映射 (SPM) 方法的估计值进行病例对照分析，然后使用临床变量的测量进行病例内分析。设置：参与者从社区招募到医院研究中心。参与者：12 名目前戒毒的前甲基苯丙胺滥用者（5 名女性，7 名男性）和年龄、 性别和 12 名教育匹配的健康对照受试者（5 名女性，7 名男性）。主要结果指标：使用甲基苯丙胺的持续时间、攻击性和抑郁症状的严重程度，以及以 [^<11>C](+)McN-5652 分布体积表示的血清素转运蛋白密度的变化。结果：与对照组相比，甲基苯丙胺滥用者表现出更高的攻击性水平 科目。 ROI和SPM分析均显示，甲基苯丙胺滥用者的全脑区域（例如中脑、丘脑、尾状核、壳核、大脑皮层和小脑）的血清素转运蛋白密度显着低于对照受试者，并且发现这种降低与甲基苯丙胺使用的持续时间显着负相关。此外，SPM 分析表明，眶额区、颞叶区和前扣带区的密度与甲基苯丙胺滥用者的攻击性程度密切相关。 结论：长期滥用甲基苯丙胺可能会降低大脑中血清素转运蛋白的密度，导致攻击性升高，即使对于目前处于戒断状态的人也是如此。较少的

项目成果

三辺 義雄: "覚醒剤使用者のセロトニン・トランスポーター脳内密度と精神症状との関連に関する研究"平成15年度精神薬療研究年報. (印刷中).

Yoshio Mibe：“兴奋剂使用者血清素转运蛋白脑密度与精神症状之间关系的研究”2003 年精神药理学治疗研究年度报告（正在出版）。

Reduced brain serotonin transporters associated with elevated aggression in abstinent methamphetamine abusers

大脑血清素转运蛋白减少与戒除甲基苯丙胺滥用者的攻击性增加有关

• 发表时间: 2005
• 期刊: Archives of General Psychiatry (In Press)
• 作者: K;Sekine Y;Ouchi Y;Takei N;Minabe Y et al.
• 通讯作者: Minabe Y et al.

Reduced brain serotonin transporters associated with elevated azaression in abstinent methamnhetamine abusers

大脑血清素转运蛋白减少与戒毒甲基苯丙胺滥用者的攻击性升高相关

• 发表时间: 2005
• 期刊: Archives of General Psychiatry in press
• 作者: K;Sekine Y;Ouchi Y;Takei N;Minabe Y et al.
• 通讯作者: Minabe Y et al.

Metabolite Alterations' in Basal Ganglia Associated with Psychiatric Symptoms of Abstinent Toluene Users : A Proton MRS Study

基底神经节代谢物改变与戒除甲苯使用者的精神症状相关：一项质子 MRS 研究

• 发表时间: 2004
• 期刊: Neuropsychopharmacology 29・5
• 作者: Tsuchiya K.J.;Takei N.;Kawai Masayoshi;Toyota Tomoko;Tsuchiya Kenji;Takebayashi Kiyokazu
• 通讯作者: Takebayashi Kiyokazu