Mutations of CD38 in autism spectrum disorder and oxytocin treatment.

自闭症谱系障碍和催产素治疗中的 CD38 突变。

• 批准号: 20390311
• 负责人: MINABE Yoshio
• 金额: $ 11.81万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390311/
• 关键词: 自閉症; オキシトシン; CD38; 遺伝子研究; 脳画像研究; 全般性発達障害; MEG; NIRS; 遺伝子; 医療・福祉; シグナル伝達; 神経科学; 臨床

(1) We investigated the genetic variants of CD38 in subjects with autism spectrum disorder in association with symptomatology and Oxytocin plasma levels. (2) Single-blind, placebo-controlled study with 20 healthy male subjects demonstrated that oxytocin treatment results in considerable individual variability. There was no adverse event with this treatment. (3) In Japan, we followed up some patients whose family voluntary started to treat them with oxytocin nasal spray. Some patients who have some specific clinical feature showed the apparent improvement.

(1)研究自闭症谱系障碍患者CD38基因变异与症状、催产素水平的关系。(2)对20名健康男性受试者进行的单盲、安慰剂对照研究表明，催产素治疗导致了相当大的个体差异。这种治疗没有发生任何不良事件。(3)在日本，我们对一些家庭自愿开始使用催产素鼻腔喷雾剂的患者进行了随访。一些有一定临床特征的患者表现出明显的改善。

项目成果

Attentional engagement to sound : cortical hemodynamics assessed with near-infrared snectrosconv.

对声音的注意力参与：用近红外 snectroscon 评估皮质血流动力学。

• 发表时间: 2010
• 期刊: Proceedings of the Acoustical Society of Japan
• 作者: Remijn;G.B.;et al.
• 通讯作者: et al.

Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders.

• DOI: 10.1001/archgenpsychiatry.2011.4
• 发表时间: 2011-03
• 期刊: Archives of general psychiatry
• 作者: Katsuaki Suzuki;G. Sugihara;Y. Ouchi;Kazuhiko Nakamura;M. Tsujii;M. Futatsubashi;Y. Iwata;K. Tsuchiya;Kaori Matsumoto;K. Takebayashi;Tomoyasu Wakuda;Y. Yoshihara;Shiro Suda;M. Kikuchi;N. Takei;Toshiro Sugiyama;T. Irie;N. Mori

Bambi Plan : project with NIRS/MEG integrated device for the early detection of autism spectrum disorder in preschool children

Bambi 计划：采用 NIRS/MEG 集成设备的项目，用于早期检测学龄前儿童自闭症谱系障碍

• 发表时间: 2010
• 作者: 西村力;他;三辺義雄
• 通讯作者: 三辺義雄

NIRS-measurements of cortical hemodynamic activity in adults and preschool infants in response to static and motion stimuli.

NIRS - 测量成人和学龄前婴儿对静态和运动刺激的皮质血流动力学活动。

• 发表时间: 2010
• 作者: Remijn;G.B.;et al.
• 通讯作者: et al.

バンビプランの紹介 ―広汎性発達障害の診断・治療・経過観察総合システムの開発―

Bambiplan 简介 - 开发用于广泛性发育障碍的诊断、治疗和后续观察的综合系统 -

• 发表时间: 2009
• 作者: 鳥居洋太、入谷修司;ほか;鈴木道雄;菊知充
• 通讯作者: 菊知充