Mutations of CD38 in autism spectrum disorder and oxytocin treatment.

(1)研究自闭症谱系障碍患者CD38基因变异与症状和催产素血浆水平的关系。(2) 20名健康男性受试者的单盲、安慰剂对照研究表明，催产素治疗导致了相当大的个体差异。这种治疗没有出现不良事件。(3)在日本，我们对一些家属自愿开始使用催产素鼻腔喷雾剂治疗的患者进行了随访。一些具有特殊临床特征的患者表现出明显的改善。

(1) We investigated the genetic variants of CD38 in subjects with autism spectrum disorder in association with symptomatology and Oxytocin plasma levels. (2) Single-blind, placebo-controlled study with 20 healthy male subjects demonstrated that oxytocin treatment results in considerable individual variability. There was no adverse event with this treatment. (3) In Japan, we followed up some patients whose family voluntary started to treat them with oxytocin nasal spray. Some patients who have some specific clinical feature showed the apparent improvement.