Mutations of CD38 in autism spectrum disorder and oxytocin treatment.

(1)我们研究了自闭症谱系障碍受试者中CD38的遗传变异与自闭症和催产素血浆水平的关系。(2)20名健康男性受试者的单盲、安慰剂对照研究表明，催产素治疗导致相当大的个体差异。该治疗未发生不良事件。(3)在日本，我们随访了一些患者，他们的家人自愿开始用催产素鼻喷雾剂治疗他们。部分有特殊临床表现的患者病情明显好转。

(1) We investigated the genetic variants of CD38 in subjects with autism spectrum disorder in association with symptomatology and Oxytocin plasma levels. (2) Single-blind, placebo-controlled study with 20 healthy male subjects demonstrated that oxytocin treatment results in considerable individual variability. There was no adverse event with this treatment. (3) In Japan, we followed up some patients whose family voluntary started to treat them with oxytocin nasal spray. Some patients who have some specific clinical feature showed the apparent improvement.