Electrophysiological studies on the action of antipsychotic drugs

抗精神病药物作用的电生理学研究

• 批准号: 04670696
• 负责人: MINABE Yoshio
• 金额: $ 1.41万
• 依托单位: National Institute of Neuroscience (1993-1994)Toyama Medical and Pharmaceutical University (1992)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670696/
• 关键词: Antipsychotics; dopamine; Serotonin; extracllular single-unit recording; kindling; hippocampus; epilepsy; neuroplasticity

1.Research on hippocampal kindling(1) We recorded the dynamic changes of field evoked potentials of dentate gyrus triggered by perforant pathway during the 2Hz-kindling stimulation. Our result showed that the collapse of paired-pulse depression, which should show the local inhibitory volley around the stimulating site, occurred after the appearance of epileptic afterdischarge.(2) GABA-B antagonist and NMDA antagonists caused the elevation of seizure threshold more preferentially than the reduction of AD.K^+opener and AMPA antagonist showed the opposite spectrum of antiepileptic action.2.Research on spontaneously active dopamine cells(1) Fluoxetine, a serotonin-uptake inhibitor, increased the number of dopamine cells. PCPA,which depletes the content of serotonin of the brain, decreased it.(2) Neurotesin antagonist and Neurokinin antagonist both decreased the number of dopamine cells.(3) Lewis rats showed less number of dopamine cells, more bursting pattern of dopamine cells and more increased susceptibility of dopamine reseptors, compared with Fisher rats.

1.海马点燃的研究（1）记录2 Hz点燃过程中齿状回穿支通路触发的场诱发电位的动态变化。结果表明，成对脉冲抑制的崩溃发生在癫痫后放电出现之后，表现为刺激部位周围的局部抑制性放电。(2)GABA-B受体拮抗剂和NMDA受体拮抗剂的抗癫痫作用比AD受体拮抗剂更优先引起癫痫发作阈的升高，而K^+开放剂和AMPA受体拮抗剂的抗癫痫作用则相反。2.自发活动多巴胺细胞的研究（1）氟西汀（Fluoxetine）是一种摄取多巴胺的抑制剂，它能增加多巴胺细胞的数量。PCPA，消耗脑中5-羟色胺的含量，降低它。(2)Neurotesin拮抗剂和Neurokinin拮抗剂均使多巴胺细胞数减少。(3)与Fisher大鼠相比，刘易斯大鼠的多巴胺细胞数量较少，多巴胺细胞的爆发模式更多，多巴胺受体的敏感性更高。

项目成果

Minabe Y.: "The effect of acute and chronic administration of BRL46470A on spontaneously active midbrain dopaminergic cells" Drug Dev.Res.(印刷中). (1994)

Minabe Y.：“BRL46470A 的急性和慢性给药对自发活跃的中脑多巴胺能细胞的影响”Drug Dev.Res（出版中）。

Minabe Y.etal: "Two types of neuroplasticities in the kindling phenomenon : effects of chronic MK-801 and methamphetamine." Brain Research. 585. 237-242 (1992)

Minabe Y.etal：“点燃现象中的两种神经可塑性：慢性 MK-801 和甲基苯丙胺的影响。”

Minabe Y.etal: "Two types of neuroplasticities in the kindling phenomenon. (In Japanese)" Brian Science and Mental Disorders. 3. 489-493 (1992)

Minabe Y.etal：“点燃现象中的两种神经可塑性。（日语）”布莱恩科学与精神障碍。

Minabe Y.: "Two types of neuroplasticities in the kindling phenomenon:effects of chronic MK-801 and methamphetamine" Brain Research. 585. 237-242 (1992)

Minabe Y.：“点燃现象中的两种神经可塑性：慢性 MK-801 和甲基苯丙胺的影响”大脑研究。

Minabe Y.: "Effocts of long stimulus-in tervals on the hippocampal kindling" Brain Research. (1992)

Minabe Y.：“长刺激间隔对海马点燃的影响”大脑研究。