The experimental study of the induction of tissue regeneration filling in the thoracic cavity using the bioabsorbable materials slowly releasing growth factors.

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We investigated whether the lactic acid and caprolactone copolymer cube (PLA-C) induce granulation in the thoracic cavity and evaluated the efficiency of sprinkled basic fibroblast growth factor slow releasing gelatin micro-spheres (FGF-GMS).Six rabbits underwent pneumonectomy as the control. The PLA-Cs were placed in the post pneumonectomy cavity in the other 4 as the PLA-C group. The PLA-Cs were placed in the cavity with sprinkling FGF-GMS in the last 6 as the PLA-C+FGF group. We examined the excised materials in each group at 1, 2 and 3 months, respectively.In the control, there was no growth of granulation. The fibrous collagen layer covered on the every implanted PLA-Cs. Induction of granulation was limited inside of the PLA-C, started from peripheral area of the PLA-C and continued at 3 months in the PLA-C group but decayed in the PLA-C+FGF groups. The inflammatory cells invaded into the PLA-C along the septum of the PLA-C. FGF-GMS conducted the fibroblasts invasion into the pores and accelerated the thickening of the covering fibrous layer.The granulation could be controlled by the size of the PLA-C. The degradation periods of PLA-C might be controlled by the size of the PLA-C, its pore size and additional FGF-GMS.