Epigenetic control of the genome functions of transgenic insect

为了了解染色质的表观遗传修饰与DNA代谢和染色体结构维持之间的分子关系，我们分析了家蚕全着丝粒染色体的组蛋白密码及其在构成异染色质形成中的作用。首先，确定了家蚕组蛋白H3的组蛋白编码。然后，克隆了H3K9-HP1和H3K27-Polycomb体系的几乎所有组分，并分析了它们在构成异染色质形成中的作用。最后，揭示了家蚕动粒的分子结构。

In order to understand the molecular relationship between the epigenetic modification of chromatin and DNA metabolism, and maintenance of chromosomal structure, we analyzed the histone code of silkworm holocentric chromosomes and its role on the formation of constitutive heterochromatin. First, the histone code of silkworm histone H3 was determined. Then, almost all components of H3K9-HP1and H3K27-Polycomb systems had been cloned and their roles on the formation of constitutive heterochromatin were analyzed. Finally, the molecular structure of silkworm kinetochore was revealed.