Efficient Synthesis of Biologically Active Natural Products Useful for Drug Discovery

我们对天然产物的全合成进行了研究，这些天然产物具有有趣的生物活性，可用于药物发现。从而实现了恶唑霉素A和猫脑素的全合成，以及威威司他汀的正式合成。此外，我们还开发了一种基于Rh(II)催化的C-H胺化反应来构建杂环化合物的新方法，并实现了NW-G01、工程师A和肌霉素A、B、C的全合成。

We have studied on the total synthesis of natural products having intriguing biological activities useful for drug discovery. As a result, we have achieved the total syntheses of oxazolomycin A and kitocephalin, and the formal synthesis of welwistatin. In addition, we have developed a new methodology for the construction of heterocycles which relies on a Rh(II)-catalyzed C-H amination reaction, and have achieved the total syntheses of NW-G01, englerin A, and inthomycin A, B, C.