Efficient Synthesis of Biologically Active Natural Products Useful for Drug Discovery

我们研究了具有有趣的生物活性的天然产物的全合成，对药物发现有用。最终，我们实现了恶唑霉素a和kitocephalin的全合成，并正式合成了威司他汀。此外，我们还开发了一种依靠Rh（II）催化的C- h胺化反应构建杂环的新方法，并实现了NW-G01、englerin a和inthomycin a、B、C的全合成。

We have studied on the total synthesis of natural products having intriguing biological activities useful for drug discovery. As a result, we have achieved the total syntheses of oxazolomycin A and kitocephalin, and the formal synthesis of welwistatin. In addition, we have developed a new methodology for the construction of heterocycles which relies on a Rh(II)-catalyzed C-H amination reaction, and have achieved the total syntheses of NW-G01, englerin A, and inthomycin A, B, C.