Comprehensive study of an implantable total artificial heart using continuous flow blood pump

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The total artificial heart (TAH) is expected to be an ultimate device for heart replacement. To develop small-size implantable TAH with high performance, improvement of the undulation pump TAH and development of the helical flow TAH (HFTAH) that is a next generation TAH were performed. The newly developed HFTAH was implanted in goats and 100 days of maximum survival was obtained by providing 1/R control that is a physiological control method of the TAH. In the experiment of treadmill exercise with the nonpulsatile TAH, there found no obvious difference between pulsatile and nonpulsatile TAHs. To develop an implantable controller, calibration method of implantable pressure sensor (IPS) and estimation logic of mean atrial pressure using IPS were performed. To improve biological compatibility of device parts, the hybrid parts constructed with fusion of artificial material and biological material were developed.