Comprehensive study of an implantable total artificial heart using continuous flow blood pump

全人工心脏有望成为心脏置换的终极装置。为了研制高性能的小型植入式热泵，对波动泵热泵进行了改进，研制了新一代的螺旋流热泵(HFTAH)。将新研制的HFTAH植入山羊体内，通过提供TAH的生理控制方法1/R对照，获得了最大存活100天。在非搏动性TAH的跑台运动实验中，脉动型和非脉动型TAH之间无明显差异。为了研制植入式压力传感器，提出了植入式压力传感器的标定方法和利用植入式压力传感器估计平均心房压的逻辑。为提高设备部件的生物相容性，研制了人工材料与生物材料融合构建的混杂部件。

The total artificial heart (TAH) is expected to be an ultimate device for heart replacement. To develop small-size implantable TAH with high performance, improvement of the undulation pump TAH and development of the helical flow TAH (HFTAH) that is a next generation TAH were performed. The newly developed HFTAH was implanted in goats and 100 days of maximum survival was obtained by providing 1/R control that is a physiological control method of the TAH. In the experiment of treadmill exercise with the nonpulsatile TAH, there found no obvious difference between pulsatile and nonpulsatile TAHs. To develop an implantable controller, calibration method of implantable pressure sensor (IPS) and estimation logic of mean atrial pressure using IPS were performed. To improve biological compatibility of device parts, the hybrid parts constructed with fusion of artificial material and biological material were developed.