Health consequences after Covid-19 infection: Are there persistent health impairments? An epidemiological study at the University Hospital of Essen

Covid-19 感染后的健康后果：是否存在持续的健康损害？

• 批准号: 458514228
• 负责人: Professor Dr. Karl-Heinz Jöckel
• 金额: --
• 依托单位: Institut für Medizinische Informatik, Biometrie und Epidemiologie (IMIBE)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/458514228?language=en
• 关键词: Health; consequences; after; Covid; 19

First, still unsystematic observations and smaller studies suggest that Covid-19 patients treated in hospital continue to show symptoms typical of Covid-19 even after discharge, and that the new coronavirus can be detected not only in the airways and lungs, but also in the pharynx, heart, liver, kidney and brain. There is also evidence that SARS-CoV-2 could have a diabetogenic effect in people infected with covid-19 and cause neurological and psychiatric impairment.The Institute of Medical Informatics, Biometry and Epidemiology therefore applies for a project with the aim of clarifying whether a Covid-19 infection is associated with persistent health problems in a broad patient population which is not focused on hospitalized persons. In the study, positively tested persons are to be compared with negatively tested persons and persons from the general population, particularly with regard to psychosocial, cognitive, metabolic, pulmonary and cardiovascular factors. At the time of the planned study, the test for the virus should have been performed at least 12 months ago. The central questions of the study aim to determine whether the three study groups differ with regard to quality of life, cognitive performance, lung function, the presence of poorly controlled diabetes mellitus and the presence of subatherosclerotic factors. The diversity of the variables investigated ensures the interdisciplinary orientation of the project.In the Essen urban area, approximately 1000 people have so far been tested positive for Covid-19 and a further 7000 people negative. In cooperation with the Health Department of the City of Essen, 400 positive and 400 negative tested persons will be randomly selected and invited to participate in the present study. The third study group of 800 additional persons from the general population will be selected from the Heinz Nixdorf MultiGenerationsStudy (MGS) already underway at the Institute for Medical Informatics, Biometry and Epidemiology. The applicants have already carried out a study with around 5500 Essen citizens in the context of the pandemic control of the city of Essen. A first result was the establishment of a score to identify persons who have an increased probability of a positive test result. Furthermore, the applicants have many years of experience in conducting epidemiological field studies (e.g. Heinz-Nixdorf Recall Study (HNR), 1000 Brain Study, HNR MultiGenerationsStudy (MGS) and the National Cohort (NAKO)). Within the framework of the planned study, the participants will undergo an examination programme that is firmly established in the study centre of the Institute for Medical Informatics, Biometry and Epidemiology.

首先，仍不系统的观察和较小规模的研究表明，在医院接受治疗的新冠肺炎患者即使在出院后仍继续表现出典型的新冠肺炎症状，而且新型冠状病毒不仅可以在气道和肺部检测到，还可以在咽部、心脏、肝脏、肾脏和大脑中检测到。还有证据表明，SARS-CoV-2可能对感染Covid-19的人产生致糖尿病效应，并导致神经和精神损害。因此，医学信息学、生物测量学和流行病学研究所申请了一个项目，旨在澄清Covid-19感染是否与广泛患者人群（不集中在住院患者）的持续健康问题有关。在这项研究中，将对测试结果呈阳性的人与测试结果呈阴性的人和一般人群进行比较，特别是在社会心理、认知、代谢、肺和心血管因素方面。在计划研究时，病毒检测应至少在12个月前进行。本研究的中心问题旨在确定三个研究组在生活质量、认知能力、肺功能、控制不良的糖尿病的存在以及亚动脉粥样硬化因子的存在方面是否存在差异。在埃森市区，迄今为止，约有1000人被检测为新冠肺炎阳性，另有7000人被检测为阴性。与埃森市卫生部门合作，将随机选择400名阳性和400名阴性受试者，并邀请其参加本研究。第三个研究组将从普通人群中选出800名额外的人，这些人将来自医学信息学、生物统计学和流行病学研究所正在进行的海因茨尼克斯多夫多代研究（MGS）。申请人已经在埃森市流行病控制的背景下对大约5500名埃森市民进行了一项研究。第一个结果是建立了一个分数，以确定谁具有阳性测试结果的概率增加的人。此外，申请人在开展流行病学现场研究（例如Heinz-Nixdorf回忆研究（HNR）、1000脑研究、HNR多代研究（MGS）和国家队列研究（NAKO））方面拥有多年经验。 在计划的研究框架内，参与者将接受在医学信息学、生物统计学和流行病学研究所研究中心牢固建立的检查方案。