Genetic predisposition to pathologic inflammation in trauma patients with respect to the ISS based on data from cooperating centers

基于合作中心的数据，与 ISS 相关的创伤患者病理性炎症的遗传倾向

• 批准号: 5407453
• 负责人: Professor Dr. Karl-Heinz Jöckel
• 金额: --
• 依托单位: Institut für Medizinische Informatik, Biometrie und Epidemiologie (IMIBE)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2003
• 资助国家: 德国
• 起止时间: 2002-12-31 至 2006-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5407453?language=en
• 关键词: Genetic; predisposition; pathologic; inflammation; trauma

In Germany, trauma has a relevant share in the causes of death, the costs of therapy for acute illness, long-term mortality and subsequent economic costs. Depending on the severity of the trauma, posttraumatic patients develop a systemic inflammatory response syndrome (SIRS), which decisively determines the individual clinical course of the patient. So far, the understanding of the responsible (intra-)cellular regulatory mechanisms remains limited. While various studies within the joint project focus on global patterns of expression and genotyping of chosen candidate genes, the aim of this project is to study familial predisposition based on an epidemiological approach. In order to plan and initiate an epidemiological study adequately, knowledge on risk factors promoting traumatic inflammatory response will be gained during the first part of this project. Selected data from the trauma registry (provided by the German Trauma Society) will be systematically analysed in order to detect influencing variables and to perform subgroup analyses. Parallel to this, a questionnaire to quantify pathologic immune response in first degree relatives of patients shall be developed and evaluated in a pilot study. These parameters need to be taken into account as potential risk factors in the planning of a following case-control study. In this study prospective data on trauma patients will be collected from cooperating centers. Patients will be defined as cases or controls depending on their outcome (multiple organ failure). Family history of pathologic immune response patterns (wound healing disorder, disposition to sepsis, multiple organ failure, etc.) will be studied and compared in cases and controls, respectively.

在德国，创伤在死亡原因、急性病治疗费用、长期死亡率和随后的经济成本中占有相当大的份额。根据创伤的严重程度，创伤后患者发展为全身炎症反应综合征（SIRS），这决定性地决定了患者的个体临床病程。到目前为止，对负责的（内）细胞调节机制的理解仍然有限。虽然联合项目内的各种研究侧重于选定的候选基因的表达和基因分型的全球模式，本项目的目的是研究基于流行病学方法的家族易感性。为了充分规划和启动流行病学研究，将在本项目的第一部分获得有关促进创伤性炎症反应的风险因素的知识。将对创伤登记处（由德国创伤学会提供）的选定数据进行系统分析，以检测影响变量并进行亚组分析。与此同时，应在初步研究中制定并评价一份问卷，以量化患者一级亲属的病理性免疫应答。这些参数需要考虑作为潜在的风险因素，在规划下一个病例对照研究。在本研究中，将从合作中心收集有关创伤患者的前瞻性数据。患者将根据其结局（多器官衰竭）定义为病例或对照。病理性免疫反应模式家族史（伤口愈合障碍、脓毒症倾向、多器官衰竭等）将分别在病例组和对照组中进行研究和比较。