Development of Biocompatible Silk Nonwoven Fabrics

生物相容性蚕丝非织造布的开发

• 批准号: 11556011
• 负责人: ITO Hiraku
• 金额: $ 7.42万
• 依托单位: Heian Jogakuin College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11556011/
• 关键词: Silk Nonwoven Fabric; Sankenshi; Needle Punching; Animal Experiment; Foreign Body Reaction; Absobability; Biocompatibility

Tissue biocompatiblity of sik nonwoven fabrics was examined by in vivo test. Two types of nonwoven fabrics were used as sample material. One is produced from silk fibers from usual cocoon by using the nonwoven forming process (P type). The other is natural nonwoven fabric (so called "Sankenshi : S type), which was directly produced by the special silkworms of "Ishiko-san". This silkworms have a characteristics to produce flat type cocoon (Sankenshi) instead of usual type cocoon. In the animal experiments (in this work rabbit), the skin defect of 10×7 cm was created in the back, and the nonwoven samples (3×3cm) were implanted on the defect under contacting with subcutaneous tissue. In vivo test results showed that both types of nonwoven fabrics have very little foreign body reaction, namely have good biocompatibility. In addition, these samples induced a good effect for the healing of skin wound. These samples were not absorbed after 4 weeks implantation. Silk nonwoven fabrics are expected to become a useful tissue biocompatible implant material.

采用体内生物相容性试验研究了植丝非织造布的组织相容性。两种类型的非织造织物被用作样品材料。一种是用普通蚕茧的丝纤维通过非织造成形工艺生产的（P型）。另一种是天然无纺布（所谓的“Sankenshi：S型”），这是直接由“Ishiko-san”的特殊蚕生产的。该蚕具有产平型茧（三垦氏）而不产普通型茧的特点。在动物实验中（在本工作兔中），在背部造成10×7 cm的皮肤缺损，并在与皮下组织接触的情况下将非织造布样品（3×3cm）植入缺损处。体内试验结果表明，两种类型的非织造布的异物反应都很小，即具有良好的生物相容性。此外，这些样品对皮肤创伤的愈合诱导了良好的效果。这些样品在植入4周后未被吸收。蚕丝非织造布有望成为一种有用的组织生物相容性植入材料。

项目成果

T.Nakashima,H.Ito,and M.Matsuo : "Biodegradation of high strength and high modulus PE-starch composite filmsburied in several kinds of"J.Macromol.Sci.,Phys.. (in press).

T.Nakashima、H.Ito 和 M.Matsuo：“埋藏在几种物质中的高强度和高模量 PE-淀粉复合膜的生物降解”J.Macromol.Sci.,Phys..（出版中）。

H.Ito,H.Sasaki,T.Imamura: "Dyeing behavior of silk proteins in relation to silkworm diet"Textile Research Journal. 69-11. 825-828 (1999)

H.Ito，H.Sasaki，T.Imamura：“丝蛋白的染色行为与蚕饮食的关系”纺织研究杂志。

H.Sasaki, N.Donkai, H.Ito, K.Imamura, H.Morikawa: "Dyeing properties of silk produced by silkworms reared on artificial and mulberry leaf diets"J.Soc.Dyer Colourists. 116. 349-351 (2000)

H.Sasaki、N.Donkai、H.Ito、K.Imamura、H.Morikawa：“人工和桑叶饲料饲养的蚕产生的丝绸的染色特性”J.Soc.Dyer Colourists。

K.Matsumura,S.-H.Hyon,N.Nakajima et al.: "Surface Modification of Poly (ethylene-vinyl alchohol)(EVA).Part I. Introduction of Carboxyl Groups and"J.Biomed.Mater.Res.. 50. 512-517 (2000)

K.Matsumura、S.-H.Hyon、N.Nakajima 等：“聚(乙烯-乙烯醇)(EVA) 的表面改性。第一部分：羧基的介绍”和“J.Biomed.Mater.Res”。

H.Ito,H.Sasaki et al.: "Dyeing behavior of silk proteins in relation to Silkworn diet"Textile Res.J.. 69. 825-828 (1999)

H.Ito、H.Sasaki 等人：“丝蛋白的染色行为与 Silkworn 饮食相关”Textile Res.J. 69. 825-828 (1999)