Protein function and module shuffling

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The aim of this research project was to develop a method to predict function of proteome on the bases of knowledge of protein module.Since module is defined by using three-dimensional structure of proteins, its conformation and function are conserved during evolutionary processes. Thus, it is valuable, to use module information than to use amino acid sequence signature or motifs in prediction of genome function. We have deduced sequence pattern information by classification of modules, developed 3D-key note method and applied it to predict function of genome sequences of various species. Our prediction for a gene was proved experimentally in cyanobacterium Synechocystis. Particularly, we applied our method to annotate human genome. We published several papers and data bases as products of this project (URL:http://daisy.nagahama-i-bio.ac.jp/golab/hetpdbnavi.html), (URL:http://daisy.nagahama-i-bio.ac.jp/famsbase/index.html), (URL:http://daisy.nagahama-i-bio.ac.jp/keynote/AK074299.html).