the maintenance and circulation of protein higher-order structural information and the evaluation of prediction information
蛋白质高阶结构信息的维护和循环以及预测信息的评估
基本信息
- 批准号:12207002
- 负责人:
- 金额:$ 50.24万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research on Priority Areas
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2002
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Mainly through the following research products and activities for three years, we conducted the maintenance and circulation of protein higher-order structural information and the evaluation of prediction information.Every year we held the open workshop of "Genome Information Science Based on Protein Higher-order Structures (Higher-order Genome)", including poster presentations of the "Higher-order Genome" group and a one-day symposium. In the first year, we invited two overseas speakers from the field of protein architecture and bioinformatics and held an international symposium. In the second year, in preparation for coming days of higher-order structural information flood according to rapid progress of the structural genomics, we held the open symposium titled "Information Biology as Structural Genome Science--When All Protein Structures of the Representative Proteins Are Clarified--", enhancing cooperation with structural biologists. Decoding of genome information would be incomplet … More e without understanding of proteins, main actors playing direct roles for physiological phenomena, and simulation studies are occupying an important position as a means for that aim. In the third year, we thus held the international symposium titled "Frontier Bioinformatics--To What Extent Can Simulations Clarify Protein Functions?", where four overseas researchers were invited."One-day symposium of computational structural genomics" was also held as a satellite meeting of "International Conference on Structural Genomics (ICSG) in 2000. Additionally, we executed various activities including research meetings of the "Higher-order Genome" group, support of young researcher's study meetings, travel support to attend the international meeting of "Critical Assessment of Techniques for Protein Structure Prediction (CASP)" and cooperation with alga researchers in "Genome Biology".On the other hand, we constructed as complete sets of comparative protein structure models as possible for the whole genome ORFs presented in GTOP database and publicly released as FAMSBASE (http://daisy.nagahama-i-bio.ac.jp/Famsbase/). A statistical analysis of the data was also published. Less
三年来主要通过以下研究产品和活动,进行蛋白质高阶结构信息的维护和流通以及预测信息的评估。每年都会举办“基于蛋白质高阶结构的基因组信息科学(高阶基因组)”公开研讨会,包括“高阶基因组”组的海报展示和为期一天的研讨会。第一年,我们邀请了两位来自蛋白质结构和生物信息学领域的海外演讲者,并举办了国际研讨会。第二年,为了迎接结构基因组学快速发展带来的高阶结构信息洪流,我们举办了题为“信息生物学作为结构基因组科学——当所有代表性蛋白质的结构都被阐明——”的公开研讨会,加强了与结构生物学家的合作。如果不了解蛋白质,对基因组信息的解码将是不完整的,主要参与者在生理现象中发挥直接作用,而模拟研究作为实现这一目标的手段占据着重要地位。第三年,我们举办了题为“前沿生物信息学——模拟在多大程度上可以阐明蛋白质功能?”的国际研讨会,邀请了四位海外研究人员。“计算结构基因组学一日研讨会”也作为2000年“国际结构基因组学会议(ICSG)的卫星会议”举行。此外,我们还开展了包括“高阶基因组”研究会议在内的各种活动。 一方面,我们为青年研究员的研究会议提供支持,参加“蛋白质结构预测技术批判性评估(CASP)”国际会议的差旅支持,以及与藻类研究人员在“基因组生物学”方面的合作。另一方面,我们为GTOP数据库中呈现的全基因组ORF构建了尽可能完整的一套比较蛋白质结构模型,并以FAMSBASE的形式公开发布 (http://daisy.nagahama-i-bio.ac.jp/Famsbase/)。还发布了数据的统计分析。少
项目成果
期刊论文数量(404)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
kdsA mutations affect FtsZ-ring formation in Escherichia coli K-12
- DOI:10.1099/00221287-148-1-103
- 发表时间:2002-01-01
- 期刊:
- 影响因子:2.8
- 作者:Fujishima, H;Nishimura, A;Nagai, K
- 通讯作者:Nagai, K
Protein structure comparison using the Markov transition model of evolution
- DOI:10.1002/1097-0134(20001001)41:1<108::aid-prot130>3.0.co;2-s
- 发表时间:2000-10-01
- 期刊:
- 影响因子:2.9
- 作者:Kawabata, T;Nishikawa, K
- 通讯作者:Nishikawa, K
GTOP: a database of protein structures predicted from genome sequences
- DOI:10.1093/nar/30.1.294
- 发表时间:2002-01-01
- 期刊:
- 影响因子:14.9
- 作者:Kawabata, T;Fukuchi, S;Nishikawa, K
- 通讯作者:Nishikawa, K
Shionyu, M. et al.: "Variable subunit contact and cooperativity of hemoglobins."J.Mol.Evol.. 53. 416-429 (2001)
Shionyu, M. 等人:“血红蛋白的可变亚基接触和协同性。”J.Mol.Evol.. 53. 416-429 (2001)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
GTOP : from genomic information to a prediction for protein tertiary structure-building a database and utilize it for an applied research
GTOP:从基因组信息到蛋白质三级结构的预测——建立数据库并将其用于应用研究
- DOI:
- 发表时间:2002
- 期刊:
- 影响因子:0
- 作者:Nishikawa;K.
- 通讯作者:K.
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{{ truncateString('GO Mitiko', 18)}}的其他基金
Studying Function of Alternative Splicing Products Based on Protein Structure Modeling
基于蛋白质结构建模的选择性剪接产物功能研究
- 批准号:
18370061 - 财政年份:2006
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Simulation of Protein Folding Process
蛋白质折叠过程模拟
- 批准号:
15300101 - 财政年份:2003
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Decoding of genome function and evolution based on the 3D structures of proteins
基于蛋白质 3D 结构解码基因组功能和进化
- 批准号:
12208006 - 财政年份:2000
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Development of a method to predict protein function based on module classification
开发基于模块分类的蛋白质功能预测方法
- 批准号:
11480189 - 财政年份:1999
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Protein function and module shuffling
蛋白质功能和模块改组
- 批准号:
11559007 - 财政年份:1999
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of design method to get soluble protein
开发获得可溶性蛋白质的设计方法
- 批准号:
08559009 - 财政年份:1996
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Method for protein design based on module units.
基于模块单元的蛋白质设计方法。
- 批准号:
06558100 - 财政年份:1994
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Classification of Protein Modules
蛋白质模块的分类
- 批准号:
06454664 - 财政年份:1994
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Structural and Functional Roles of Modules in Protein Architecture
蛋白质结构中模块的结构和功能作用
- 批准号:
02404089 - 财政年份:1990
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for General Scientific Research (A)
Structure and Function of Modules Constituting Proteins
构成蛋白质的模块的结构和功能
- 批准号:
63480515 - 财政年份:1988
- 资助金额:
$ 50.24万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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