Studies on the host related factors determining clinical manifestation of the Helicobacter pylori infection among patients with various ethnic backgrounds.

世界上有20多亿人口，日本有6000多万人感染幽门螺杆菌。还投入了巨额资金用于治疗和预防与幽门螺杆菌感染相关的疾病。并不是所有这种感染的患者都会患上消化性溃疡、恶性淋巴瘤或胃癌等疾病。解释为什么有限的患者亚群会发展成这些疾病的致病机制尚不清楚。据报道，亚洲国家不同种族背景的人群在这种感染的血清阳性率、疾病谱和临床结局方面存在差异，这不能仅仅用感染病原体的遗传差异或这些国家社会经济和社会卫生水平的差异来解释。宿主相关因素也应该决定感染的临床结果，这些因素大多是未知的。为了积累CL…为了更多的临床数据和研究发病机制，我们在日本和国外的研究人员之间建立了合作关系。1.幽门螺杆菌与胃上皮细胞相互作用产生的炎性介质，宿主粘膜免疫系统包括唾液腺和GALT(肠道相关淋巴组织)也在胃炎的组织学表现中起重要作用。2.我们发现马来西亚和日本不同种族之间的血清阳性率和血液中抗H.这可能解释了不同研究组之间胃癌发病率的差异以及感染的临床表现的差异。与捷克的调查人员进行了合作。对捷克Hp感染患者的多因素分析显示，Hp感染、胃癌家族史、胃内产生的氨水平与组织学胃炎的分级有关。较少

Huge population in the world, more than two billions, and more than sixty millions of people in Japan are infected with Helicobacter pylori (H.pylori). Huge sum of money is also invested for the treatment as well as prevention of the diseases related to H.pylori infection. Not all of the patients with this infection develop such diseases as peptic ulcers, MALTOMAs or gastric cancers. The pathogenic mechanisms explaining why limited subgroups of the patients develop these diseases are not understood. The differences in seroprevalence, disease spectrum and clinical outcome of this infection among the population with various ethnic background has been reported in Asian countries, which cannot be explained solely by genetical differences of the pathogen infected or by thedifferences in the socioeconomic as well as social sanitation levels in these countries. The host related factors should also determine clinical outcome of the infection, which are mostly unknown. In order to accumulate cl … More inical data and to study mechanisms of pathogenesis, we have established collaboration among investigators in Japan and abroad. We have obtained several findings out ofstudies utilizing human clinical samples and animal disease models.1, Not only the inflammatory mediators produced by the interaction between H.pylori and gastric epithelia, the host mucosal immune system including salivary glands and GALT (gut associated lymphoid tissue) also play important roles for the histological manifestation of the gastritis.2, We found differences in seroprevalence and profiles of antibodies to H.pylori in the blood among different ethnic groups in Malaysia and Japanese. This may explain different rate of incidence of gastric cancer and differences in clinical manifestation of the infection among study groups.3. Collaboration with investigators in Czech was carried out. Multiple parametric analyses in the patients with H.pylori infection in Czech revealed correlation among presence of H.pylori infection, family history of gastric cancer, level of ammonia produced in the stomach and grade of histological gastritis. Less