Development of Multiple Quantum NMR Spectroscopy and Imgaing : Imaging Application on Bound Water in Biological Systems.
多量子核磁共振波谱和成像的发展:生物系统中结合水的成像应用。
基本信息
- 批准号:11694305
- 负责人:
- 金额:$ 3.97万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B).
- 财政年份:1999
- 资助国家:日本
- 起止时间:1999 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Aims of this project is development of new functional MR imaging based on the multiple quantum NMR and the spectroscopic imaging to follow "order" structure of water and to use it to understand physiological processes in healthy and pathological tissues.1) Development of double-quantum-filter NMR imaging : We have introduced H-1 slice selective double-quantum-filter NMR imaging (H-1 DQF MRI) which depicted ordered water (bound water) in biological tissues selectively, and also developed H-1 and H-2 spectroscopic double-quantum-filter NMR imaging (H-1 and H-2 DQF CSI) which depict water in a certain molecular environment through selective window of molecular dynamics.2) Development of variable-angle loaded-cell H-2/H-1 probe : In order to visualize macroscopic order of the bound water, it is necessary to measure relaxation time and residual quadrapoler (or dipoler) splitting in various angle against the static magnetic field. We have built the world-first variable-angle loaded-cell probe for H-2/H-1 NMR, which can apply a static load up to 0.75 MPa to the cartilage sample with 1.0 cm in diameter.3) Visualization of collagen structure in the articular cartilage by H-2/H-1 DQF CSI : In the intact bovine articular cartilage, we can depict the collagen structures in the superficial, tangenital, deep and carcified zones, Observation and analysis on the deformation of collagen structures under static loading are under going, and might be finished in 2001.
该项目的目的是基于多量子NMR和光谱成像开发新的功能性MR成像,以遵循水的“有序”结构,并使用它来了解健康和病理组织中的生理过程。1)开发双量子滤波器NMR成像:介绍了H-1切片选择性双量子滤波核磁共振成像(H-1 DQF MRI),描绘了有序水(结合水)在生物组织中选择性地,并开发了H-1和H-2光谱双量子滤波NMR成像(H-1和H-2 DQF CSI),通过分子动力学的选择窗口描述了水在一定分子环境中的状态。2)可变角加载池H-2/H-1探针:为了直观地观察束缚水的宏观有序性,需要测量弛豫时间和在不同角度下的残余四极子(或偶极子)分裂。我们已经建立了世界上第一个用于H-2/H-1 NMR的可变角度加载细胞探针,它可以对直径为1.0 cm的软骨样品施加高达0.75 MPa的静态载荷。3)通过H-2/H-1 DQF CSI显示关节软骨中的胶原结构:在完整的牛关节软骨中,我们可以描绘出表层、切线、深层和钙化区的胶原结构,胶原结构在静态载荷下的变形观察和分析正在进行中,可能在2001年完成。
项目成果
期刊论文数量(36)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Takamiya,H.,Kusaka,Y.,Seo,Y.,Noguchi,M.,Ikoma,K., et al.: "Characteristics of proton NMR T2 relaxation of water in the normal and regenerating tendon."Jpn.J.Physiol.. 50(6). 569-576 (2000)
Takamiya,H.、Kusaka,Y.、Seo,Y.、Noguchi,M.、Ikoma,K. 等人:“正常肌腱和再生肌腱中水的质子 NMR T2 弛豫特征。”Jpn.J.
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Seo Y,Ikoma K,Takamiya H,Kusaka Y,Tsoref L,Eliav U,Shinar H & Navon G: "^1H double-quantum-filtered MR imaging as a new tool for assessment of healing of the ruptured Achilles tendon"Magn.Reso.Med.. 42. 884-889 (1999)
Seo Y,Ikoma K,Takamiya H,Kusaka Y,Tsoref L,Eliav U,Shinar H
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takamiya,H.: "Characteristics of proton NMR T2 relaxation of water in the normal and regenerating tendon."Jpn.J.Physiol.. 50. 569-576 (2000)
Takamiya,H.:“正常肌腱和再生肌腱中水的质子 NMR T2 弛豫特征。”Jpn.J.Physiol.. 50. 569-576 (2000)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Navon,G.: "Multiquantum filters and order in tissues."NMR in Biome dicine. (in press). (2001)
Navon,G.:“组织中的多量子过滤器和秩序。”生物群落医学中的核磁共振。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Tsoref, T., Eliav, U., Seo, Y., Shinar, H.& Navon, G.: "Slice-selective proton double quantum filtered MRI of joint connective tissues."J.Magn.Reson.Imag.. 11. 336-341 (2000)
Tsoref, T.、Eliav, U.、Seo, Y.、Shinar, H.
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- 影响因子:0
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{{ truncateString('SEO Yoshiteru', 18)}}的其他基金
Can cilia of ventricular ependymal cells control flow of CSF?
室管膜细胞的纤毛能否控制脑脊液的流动?
- 批准号:
15K08185 - 财政年份:2015
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$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Whether H2S is EDRF or not : Possibility of deep sea bivalves as experimental animal
H2S是否是EDRF:深海双壳类作为实验动物的可能性
- 批准号:
24659102 - 财政年份:2012
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Analysis of bulk flow in the ceiebral interstitial space measured by H-1 MRI
H-1 MRI 测量的大脑间隙总体流量分析
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18590209 - 财政年份:2006
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$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Water permeabilities of neural cells and capillaries in brain : Using claudin-5 knocked out mice and H-1 MRI
大脑中神经细胞和毛细血管的水渗透性:使用claudin-5基因敲除小鼠和H-1 MRI
- 批准号:
16590167 - 财政年份:2004
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$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Water permeability of capillaries in the subfornical organ of rats determined by Gd-DTPA^<2-> enhanced ^1H magnetic resonance imaging
Gd-DTPA^<2->增强^1H磁共振成像测定大鼠穹窿下器官毛细血管透水性
- 批准号:
13670047 - 财政年份:2001
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$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Proposal of New Functional NMR Imaging : Development of Double-Quantum-Filtered MRI
新功能核磁共振成像的提议:双量子过滤核磁共振成像的发展
- 批准号:
10557005 - 财政年份:1998
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$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Water in Sciatic Nerve Measured by Double-Quantum-Filtered NMR
通过双量子过滤 NMR 测量坐骨神经中的水分
- 批准号:
10670046 - 财政年份:1998
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$ 3.97万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
NMR and Fluorescence Studies on Exocrine Membrane Transport
外分泌膜运输的核磁共振和荧光研究
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03044153 - 财政年份:1991
- 资助金额:
$ 3.97万 - 项目类别:
Grant-in-Aid for international Scientific Research
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