Neuronal Mechanisms of Stroop Effect: Neurophysiological and Computational Approach

斯特鲁效应的神经机制：神经生理学和计算方法

• 批准号: 12410030
• 负责人: SAKAGAMI Masamichi
• 金额: $ 9.47万
• 依托单位: Tamagawa University (2001-2002)Juntendo University (2000)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12410030/
• 关键词: macaques (Japanese Monkey); prefrontal cortex; single-unit activity; Stroop effect; selective attention; decision; cingulated cortex; cognition; 前頭連合野; go; no-go反応; ムシモル; 視覚次元; 反応時間

We trained two Japanese monkeys to perform a selective attention task with multidimensional (color & random dots motion) visual stimulus. The results revealed Stroop like interference effect in monkeys' behavior, and we reported them in Journal of Experimental Psychology (Lauwereyns et al. 2000). Then we recorded single unit activity from the prefrontal cortex of the behaving monkeys. What we found were followings;1) Primate lateral prefrontal cortex plays critical roles in converting sensory information to the associated behavioral information.2) The processes are hierarchically organized.3) The process in earlier stage is done in parallel and that in later stage, in serial. The integration process from parallel to serial generates the Stroop type interference in behavior.4) These processes are related to cognitive decision-making processes rather than motor execution processes. Adding to the recording experiment, we made microinjection of muscimol (GABA agonist) into the prefrontal cortex of the behaving monkeys and got supporting data for our hypothesis based on recording results. We are now recording single-unit activity from the cingulated cortex of those monkeys, which tends to be more related to motivational aspect.

我们训练两只日本猴子在多维（颜色和随机点运动）视觉刺激下执行选择性注意任务。实验结果表明，在猴子的行为中存在Stroop样的干扰效应，我们在实验心理学杂志（Lauwereyns et al.2000）上报道了这一结果。然后，我们记录了表现良好的猴子的前额叶皮层的单个单位活动。我们的发现如下：1）灵长类外侧前额叶皮层在将感觉信息转换为相关行为信息的过程中起着关键作用; 2）这些过程是分层的; 3）前一阶段是并行的，后一阶段是串行的。从并行到串行的整合过程会产生Stroop型行为干扰。4）这些过程与认知决策过程而不是运动执行过程相关。在记录实验的基础上，我们将GABA激动剂蝇蕈醇（muscimol）微量注射到行为正常的猴子的前额叶皮层，并根据记录结果为我们的假设提供了支持数据。我们现在正在记录这些猴子的扣带皮层的单个单位活动，这往往与动机方面更相关。

项目成果

Watanabe, M. et al.: "Coding and monitoring of motivational context in the primate prefrontal cortex"Journal of Neuroscience. 22. 2391-2400 (2002)

Watanabe, M. 等人：“灵长类前额叶皮层动机环境的编码和监控”神经科学杂志。

Sakagami,M.: "The hierarchical organization of decision making in the primate prefrontal cortex."Neurosci.Res.. 34. 79-89 (1999)

Sakagami,M.：“灵长类前额皮质决策的层次结构。”Neurosci.Res.. 34. 79-89 (1999)

Lauwereyns, J.: "Feature-based anticipation of cues that predict in monkey caudate nucleus"Neuron. 33. 463-473 (2002)

Lauwereyns, J.：“基于特征的线索预测在猴子尾状核中进行预测”神经元。

Lauwereyns, J: "Interference from irrelevant features on visual discrimination by macaques : a behavioral analog of the human stroop effect"Journal of Experimental Psychology : Animal Behavior Processes. 26. 352-357 (2000)

Lauwereyns, J：“不相关特征对猕猴视觉辨别的干扰：人类斯特鲁普效应的行为模拟”实验心理学杂志：动物行为过程。

Nakamura,K.: "Effects of local inactivation of monkey medial frontal cortex in learning of sequential procedures."J.Neurophysiol.. 82. 1063-1068 (1999)

Nakamura,K.：“猴子内侧额叶皮层局部失活对顺序程序学习的影响。”J.Neurophysiol.. 82. 1063-1068 (1999)