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THE DEVELOPMENT OF TIME-RESOLVED TWO-DIMENSIONAL IMAGING INSTRUMENT FOR MONITORING MOLECULAR BEHAVIOR AT LIQUID/LIQUID INTERFACES

用于监测液/液界面分子行为的时间分辨二维成像仪器的开发

基本信息

批准号：
12450336
负责人：
SAWADA Tsuguo
金额：
$ 9.6万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

We have developed new instrument that enable us to monitor molecular behaviors at liquid/liquid interface without any perturbation. The instrument is based on Time-Resolved Quasi-Elastic Laser Scattering (QELS) method, which we have developed. In this research project, we aimed at following points, (1) To apply the QELS technique to two-dimensional imaging measurements, all necessary beams to measure QELS signal (generating scattered light and local oscillator) and QELS signals are corrected by only one lens. We can obtain two-dimensional image by scanning the lens. (2) To apply the QELS technique more widely (e.g. the samples whose one phase is turbid, liquid metal), we adopted reflective configuration. As a consequence, we succeed to develop the instrument and have applied to scientifically and industrially interesting systems as follows. (1) The dynamic molecular behavior of a phase transfer catalytic reaction at a liquid/liquid interfaces. (2) The dynamic molecular behavior of a nonlinear chemical oscillation system at water/nitrobenzene interfaces. (3) Hydrolysis reaction of phospholipid monolayer (biological membrane) by phospholipase A2 at oil/water interface. We also succeeded to improve time resolution from second to millisecond order by using new data sampling device with efficient time resolution. This improvement opens the way to monitor chemical reactions and corrective behavior of molecules at liquid/liquid interfaces which taking place in millisecond order.

我们已经开发了新的仪器，使我们能够在没有任何扰动的情况下监测液/液界面的分子行为。该仪器基于我们研制的时间分辨准弹性激光散射(QELS)方法。在本研究项目中，我们针对以下几点：(1)将QELS技术应用于二维成像测量，测量QELS信号(产生散射光和本振)所需的所有光束和QELS信号只用一个透镜进行校正。我们可以通过扫描镜头来获得二维图像。(2)为了更广泛地应用QELS技术(例如，单相为混浊的液态金属的样品)，我们采用了反射式组态。因此，我们成功地开发了该仪器，并将其应用于具有科学和工业意义的系统如下。(1)液/液界面相转移催化反应的动态分子行为。(2)水/硝基苯界面上非线性化学振荡系统的动态分子行为。(3)磷脂酶A2在油/水界面对磷脂单分子膜(生物膜)的水解反应。采用新型高效时间分辨率的数据采集器，成功地将时间分辨率从秒提高到毫秒量级。这一改进为监测发生在毫秒量级的液/液界面上的化学反应和分子的修正行为开辟了道路。