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Nano-Chemistry in Liquid by Photothermal Spectroscopy

通过光热光谱法研究液体中的纳米化学

基本信息

批准号：
10305063
负责人：
SAWADA Tsuguo
金额：
$ 20.8万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10305063/
关键词：
photothermal nanospace transient lens effects liquid liquid interface capillary wave laser breakdown stimulated Raman scattering femtoseconds 超高速ピコ秒単一分子熱レンズ液相

项目摘要

We have developed several analytical methods in order to clarify chemical phenomena in nanospace in liquid phase and shown their usefulness in this project. In highly sensitive molecular- detection in liquid nanospace, the thermal lens microscope using photothermal effects was evolved and optimized for practical applications. The photothermal signal intensity was estimated more precisely to consider the surface morphology in samples, so that we succeeded in the analysis of the antigen-antibody reactions on the cell. Further, to apply this method to monitor the chelating reaction in the 250μm width channel, we could first integrate the flow injection analysis on the glass chip. Next, we have advanced the quasi-elastic laser scattering method which can monitor the number of molecules at liquid/liquid interface, and the molecular transfer and the reaction were studied in situ. New result have been obtained on the transfer of various surfactants at the interface, the interfacial behavior o … More f phase transfer catalysis, and the hydrolysis of DPPC by a hydrolysis enzyme.Ultra fast lens effect method using femtosecond pulse laser has been developed to clarify the energy transfer mechanism from solute to solvent in liquid and the solute-solvent effect, has studied in photo-excited molecular motion and reaction. In the molecular dynamics of Auramin O in low-viscosity solutions, the fast relaxation process within several ps was found out and it was found that the relaxation time depended on the mean molecular weight of solvent. In photo isomerization of amino azobenzen, the solvent dependence on the relaxation process in the intermediated state was firstly measured.It has been founded as the novel phenomena in the liquid nanospace that the stimulated Raman scattering in laser breakdown induced plasma was emitted in the very early stage within several tens seconds. The Raman spectra obtained were characteristic and we have investigated it as the new structural analysis method in liquid.The above-mentioned analytical methods, which are based on the photothermal effect and capillary wave, are applicable for non-fluorescent molecules and their sensitivity is comparable to the fluorescent methods. It is, therefore, concluded that new nano-chemistry world in liquid is opened by them Less

我们已经开发了几种分析方法，以澄清在液相中的纳米空间中的化学现象，并显示其在该项目中的实用性。在液体纳米空间中的高灵敏度分子检测中，利用光热效应的热透镜显微镜被发展和优化以用于实际应用。通过对光热信号强度的精确估计，考虑了样品的表面形貌，成功地分析了细胞上的抗原抗体反应。此外，为了应用该方法在250μm宽的通道中监测螯合反应，我们可以首先在玻璃芯片上集成流动注射分析。其次，我们提出了准弹性激光散射方法，可以监测液/液界面上的分子数，并对分子转移和反应进行了原位研究。对各种表面活性剂在界面上的传递、界面行为、界面张力 ...更多信息为了阐明液体中溶质-溶剂间的能量传递机理和溶质-溶剂效应，发展了飞秒脉冲激光超快透镜效应方法，研究了光激发分子运动和反应。在低粘度溶液中的分子动力学研究中，发现了几ps内的快速弛豫过程，并发现弛豫时间依赖于溶剂的平均分子量。在氨基偶氮苯的光异构化反应中，首次测量了中间态弛豫过程与溶剂的关系，发现激光击穿诱导等离子体中的受激拉曼散射在几十秒内就产生了，这是液体纳米空间中的新现象。所获得的拉曼光谱具有一定的特征性，是一种新的液相结构分析方法，上述基于光热效应和毛细管波的分析方法适用于非荧光分子，其灵敏度与荧光方法相当。因此，可以得出结论，液体中的新纳米化学世界是由它们打开的。