Epidemiological Study on Lifestyle Factors and Precancerous Lesion of the Large Bowel

生活方式因素与大肠癌前病变的流行病学研究

• 批准号: 12470098
• 负责人: KONO Suminori
• 金额: $ 5.31万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470098/
• 关键词: Colorectal adenomas; Diabetes mellitus; Genetic polymorphism; Folate; Insulin-like growth factor; Gallstones; Colorectal cancer; Epidemiology; 前がん病変; IGF; 緑茶; 食物; 大腸腺腫; 喫煙; 飲酒; 遺伝子

By incorporating a lifestyle questionnaire in the preretirement health examination in the Self Defense Forces, we have integrated an epiderniological database regarding lifestyle factors and diease prevention. Subjects were male self-defense officials mostly aged early 50s. The following results were obtained:1. An increased risk of sigmoid colon adenomas associated with diabetes mellitus had been observed previously. In two independent populations, it was consistently found that diabetes mellitus was associated with an increased risk of adenomas of the proximal colon, but not of the distal colon.2. The relation of genetic polymorphisms of apolipoprotein E, glutathione S transferase and MTHFR to colorectal adenomas was examined. Apolipoprotein E4 allele was associated with a decreased risk of proximal colon adenomas, and there was a suggestive interaction between plasma folate levels and MTFHR genotype.3. Insulin-like growth factor IGF-I and binding protein IGFBP-3 have been implicated in colorectal carcinogenesis. An increased risk of colorectal adenomas associated with elevated levels of plasma IGF-I was observed especially after adjustment for IGFBP-3 and post-load 2-hour plasma glucose, It was also shown that body mass index was strongly related to both IGF-I and IGFBP-3. The latter findings indicate that the relation of body mass index to IGF-I and IGFBP-3 may differ in different populations.4. Colorectal cancer and gallstones seem to share common etiologies partly, and thus etiological research of gallstones may shed light on factors associated with colorectal cancer. While smoking was unrelated to gallstones, alcohol use was found to be protective in the formation gallstones. There was no evidence that coffee or caffeine intake is protective against gallstones. It is also found that diabetes mellitus was strongly related to liver injury.

通过在自卫队退役前健康检查中纳入生活方式问卷，我们整合了有关生活方式因素和疾病预防的表皮数据库。受试者是男性自卫官，大多数年龄在50岁出头。获得了以下结果：1.以前曾观察到与糖尿病相关的乙状结肠腺瘤风险增加。在两个独立的人群中，一致发现糖尿病与近端结肠腺瘤风险增加相关，但与远端结肠腺瘤风险无关。探讨载脂蛋白E、谷胱甘肽S转移酶和亚甲基四氢叶酸还原酶基因多态性与大肠腺瘤的关系。载脂蛋白E4等位基因与近端结肠腺瘤风险降低相关，血浆叶酸水平与MTFHR基因型之间存在交互作用.胰岛素样生长因子IGF-I和结合蛋白IGFBP-3与结直肠癌的发生有关。观察到与血浆IGF-I水平升高相关的结直肠腺瘤风险增加，特别是在调整IGFBP-3和负荷后2小时血糖后。还表明体重指数与IGF-I和IGFBP-3均密切相关。后者的研究结果表明，体重指数与IGF-I和IGFBP-3的关系在不同人群中可能存在差异.结直肠癌与胆结石的病因学有一定的相似性，因此对胆结石的病因学研究有助于了解结直肠癌的发病因素。虽然吸烟与胆结石无关，但饮酒被发现在胆结石的形成中具有保护作用。没有证据表明咖啡或咖啡因的摄入可以预防胆结石。糖尿病与肝损伤密切相关。

项目成果

Nagano J, et al.: "A prospective study of green tea and cancer incidence, Hiroshima and Nagasaki (Japan)"Cancer Causes and Control. 12(6). 501-508 (2001)

Nagano J 等人：“广岛和长崎（日本）绿茶与癌症发病率的前瞻性研究”癌症原因和控制。

Kono S, et al.: "Cigarette smoking, alcohol use and gallstone risk in Japanese men"Digestion. 65. 177-183 (2002)

Kono S 等人：“日本男性吸烟、饮酒和胆结石风险”消化。

Shinomiya S, et al.: "Apolipoprotein e genotype, serum lipids, and colorectal adenomas in Japanese men."Cancer Letters. (発表予定). (2001)

Shinomiya S 等人：“日本男性的载脂蛋白基因型、血清脂质和结直肠腺瘤”。《癌症快报》（待出版）。

Inoue H, et al.: "Glutathione S-transferase polymorphisms and risk of colorectal adenomas."Cancer Letters. (発表予定). (2001)

Inoue H 等人：“谷胱甘肽 S-转移酶多态性和结直肠腺瘤的风险”。《癌症快报》（即将出版）。

Ishizuka H, et al.: "Relation of coffee, green tea, and caffeine intake to gallstone disease in middle-aged Japanese men"European Journal of Epidemiology. (In press). (2003)

Ishizuka H 等人：“咖啡、绿茶和咖啡因摄入量与日本中年男性胆结石疾病的关系”欧洲流行病学杂志。