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Molecular epidemiological study on lifestyles, inflammation and diabetes mellitus in a population-based cohort

基于人群的生活方式、炎症和糖尿病的分子流行病学研究

基本信息

批准号：
21249044
负责人：
KONO Suminori
金额：
$ 29.2万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

In the present research project, we carried out a 5-year follow-up survey in the Kyushu University Cohort Study, a prospective study on lifestyle-related diseases, and performed cross-sectional studies based on the baseline survey in relation to serum high-sensitivity CRP and glycated hemoglobin(HbA1c). The cohort consists of 12, 948 residents aged 49-76 in the East Ward of Fukuoka City. Of them, 12, 628 persons gave consent to genotyping analysis. A total of 12, 694 subjects were invited to participate in the mail survey on lifestyle factors and morbidity. Residents who lived in the East Ward of Fukuoka City were also asked to donate venous blood for laboratory measurements. During the period from February 2010 to March 2012, 11, 606(91%) responded to the mail survey, and 10, 427(82%) participated in the blood sampling. Cross-sectional studies produced the following findings. Smoking and body mass index(BMI) were the most important determinants of serum CRP in men, and BMI was such a factor in women. A healthy dietary pattern characterized by high intakes of vegetables and fruits was associated with lower CRP levels, but the magnitude of the contribution was found to be very small. Coffee drinking was associated with lower CRP levels in men, but not in women. As regards HbA1c, alcohol use showed an inverse association in both men and women while there was no association with coffee use. Serum bilirubin was strongly, inversely associated with serum CRP and HbA1c each. Genotyping analysis was carried out in a random sample of 1, 500 men and 1, 500 women. We selected 12 genetic polymorphisms, which were considered to be potentially functional in relation to inflammation. Two polymorphisms in the CRP gene(rs3091244およびrs1205) and the APOE polymorphism(E3> E4> E2) were strongly associated with CRP levels.

在本研究项目中，我们在九州大学队列研究中进行了为期5年的随访调查，这是一项关于生活方式相关疾病的前瞻性研究，并基于基线调查进行了血清高敏CRP和糖化血红蛋白（HbA 1c）的横断面研究。该队列由福冈市东区12948名年龄在49-76岁之间的居民组成。其中，12628人同意进行基因分型分析。共有12694名受试者被邀请参加生活方式因素和发病率的邮件调查。住在福冈市东区的居民也被要求捐献静脉血进行实验室测量。在2010年2月至2012年3月期间，11，606人（91%）回复了邮件调查，10，427人（82%）参与了血液采样。横断面研究得出了以下结果。吸烟和体重指数（BMI）是男性血清CRP最重要的决定因素，而BMI是女性血清CRP最重要的决定因素。以高摄入量的蔬菜和水果为特征的健康饮食模式与较低的CRP水平相关，但发现贡献的幅度非常小。喝咖啡与男性较低的CRP水平有关，但与女性无关。至于HbA 1c，饮酒在男性和女性中都表现出负相关，而与咖啡的使用无关。血清胆红素与血清CRP和HbA 1c均呈强负相关。基因分型分析是在随机抽取的1500名男性和1500名女性中进行的。我们选择了12个基因多态性，这些基因多态性被认为与炎症有关。CRP基因的两个多态性（rs3091244-rs 1205）和APOE多态性（E3> E4> E2）与CRP水平密切相关。