Molecular epidemiological study on lifestyles, inflammation and diabetes mellitus in a population-based cohort

In the present research project，我们carried out a 5-year follow-up survey in the Kyushu University Cohort Studya prospective study on lifestyle-相关疾病，and performed cross-sectional studies based on the baseline survey in relation to serumhigh-sensitivity CRP and glycated hemoglobin(HbA1c). cohort consists of 12，948 residents aged 49-76 in the East Ward of Fukuoka City. of them, 12，628 persons gave consent to genotyping analysis. A total of 12，694 subjects invited to participate in the mail survey on lifestyle factors and morbidity.在Fukuoka的城市生活在那里也可以用来避免血腥的血腥实验室测量. During the period from February 2010 to March 2012, 11606（91%）回复邮件survey， and 10，427(82%) participated in the blood sampling.跨性别研究produced the followingfindings. Smoking and body mass index(BMI) were the most important determinants of serum CRP in men，BMI was such a factor in women. a healthy dietary pattern characterized by high intakes ofvegetables and fruits was associated with lower CRP levelsbut the magnitude of the contribution was found to be very small. Coffee drinking was associatedwith lower CRP levels in men, but not in women. As regards HbA1c，alcohol use an inverse association in both men and women while there was no association withcoffee use. Serum bilirubin was strongly，inversely with serum CRP and HbA1c each. Genotyping analysis was carried out in a randomsample of 1,500 men and 1,500 women. We selected 12 genetic polymorphisms，这两个polymorphisms in potentially functional in relation to inflammation. Two polymorphisms inthe CRP gene（rs3091244和rs1205）和the APOE polymorphism(E3> E4> E2) were strongly associatedwith CRP level。

In the present research project, we carried out a 5-year follow-up survey in the Kyushu University Cohort Study, a prospective study on lifestyle-related diseases, and performed cross-sectional studies based on the baseline survey in relation to serum high-sensitivity CRP and glycated hemoglobin(HbA1c). The cohort consists of 12, 948 residents aged 49-76 in the East Ward of Fukuoka City. Of them, 12, 628 persons gave consent to genotyping analysis. A total of 12, 694 subjects were invited to participate in the mail survey on lifestyle factors and morbidity. Residents who lived in the East Ward of Fukuoka City were also asked to donate venous blood for laboratory measurements. During the period from February 2010 to March 2012, 11, 606(91%) responded to the mail survey, and 10, 427(82%) participated in the blood sampling. Cross-sectional studies produced the following findings. Smoking and body mass index(BMI) were the most important determinants of serum CRP in men, and BMI was such a factor in women. A healthy dietary pattern characterized by high intakes of vegetables and fruits was associated with lower CRP levels, but the magnitude of the contribution was found to be very small. Coffee drinking was associated with lower CRP levels in men, but not in women. As regards HbA1c, alcohol use showed an inverse association in both men and women while there was no association with coffee use. Serum bilirubin was strongly, inversely associated with serum CRP and HbA1c each. Genotyping analysis was carried out in a random sample of 1, 500 men and 1, 500 women. We selected 12 genetic polymorphisms, which were considered to be potentially functional in relation to inflammation. Two polymorphisms in the CRP gene(rs3091244およびrs1205) and the APOE polymorphism(E3> E4> E2) were strongly associated with CRP levels.