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Molecular Epidemiology on insulin-like growth facto (IGF) and colorectal adenomas

胰岛素样生长因子（IGF）和结直肠腺瘤的分子流行病学

基本信息

批准号：
15390204
负责人：
KONO Suminori
金额：
$ 9.54万
依托单位：
KYUSHU UNIVERCITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

项目摘要

Etiological factors of colorectal adenomas were studied with special reference to insulin like growth factor (IGF) and related conditions. Frozen plasma samples of 3370 persons were used to measure IGF-I, IGFBP-3 and C-peptide, and genetic polymorphisms regarding folate, alcohol and bile acid metabolism were investigated in relation to colorectal adenoma risk. The metabolic syndrome, which is accompanied with sustained hyperinsulinemia, was strongly related to increased risk of colorectal adenomas. Glucose intolerance and high levels of C-peptide, a measure of hyperinsulinemia, were also associated with increased risk of adenomas, but neither IGF-I nor IGFBP-3 was associated with colorectal adenomas. Increased risk of colorectal adenomas associated with hyperglycemia or hyperinsulinemia is probably linked with a mechanism or mechanisms other than the IGF system. A folate-related genetic polymorphism, reportedly associated with colorectal cancer, was not related to colorectal adenomas. Nor was the ALDH2 polymorphism. However, a polymorphism of CYP7A1, an enzyme in the synthesis of bile acids, was associated with right-side colon adenomas, indicating that bile acids is linked with carcinogenesis in the right side colon. Smoking and alcohol use were both related to increased risk of colorectal adenomas, especially of distal adenomas. It was found that coffee was protective against diabetes mellitus, which is an important risk factor for colorectal adenomas. Smoking and alcohol use were related to deterioration in glucose tolerance. A dietary pattern representing high intake of dairy foods and fruits was found not only to be related to decreased risk of colorectal adenomas but also to be protective against glucose tolerance abnormality

本文对大肠腺瘤的病因进行了研究，特别是对胰岛素样生长因子（IGF）及其相关情况的研究。3370人的冷冻血浆样本用于测量IGF-I，IGFBP-3和C肽，并研究了叶酸，酒精和胆汁酸代谢的遗传多态性与结直肠腺瘤风险的关系。代谢综合征，伴随着持续的高胰岛素血症，与结直肠腺瘤的风险增加密切相关。葡萄糖耐受不良和高水平的C-肽（高胰岛素血症的一种指标）也与腺瘤风险增加相关，但IGF-I和IGFBP-3均与结直肠腺瘤无关。与高血糖或高胰岛素血症相关的结直肠腺瘤风险增加可能与IGF系统以外的一种或多种机制有关。叶酸相关的遗传多态性，据报道与结直肠癌，是不相关的结直肠腺瘤。ALDH 2多态性也不是。然而，CYP 7A 1（一种胆汁酸合成酶）的多态性与右侧结肠腺瘤相关，表明胆汁酸与右侧结肠的致癌作用有关。吸烟和饮酒都与结直肠腺瘤的风险增加有关，尤其是远端腺瘤。研究发现，咖啡可以预防糖尿病，糖尿病是结直肠腺瘤的重要危险因素。吸烟和饮酒与葡萄糖耐量的恶化有关。研究发现，高乳制品和水果摄入量的饮食模式不仅与降低结直肠腺瘤的风险有关，而且对葡萄糖耐量异常具有保护作用。

项目成果

期刊论文数量（46）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Relation of alcohol use and smorking to ghucose tolerance status in Japanese men.

日本男性饮酒和吸烟与葡萄糖耐受状态的关系。

DOI：
发表时间：
2006
期刊：
Diabetes Research and Clinical Practice 73
影响因子：
0
作者：
Mizoue T;et al.;Tabata S;Sakai Y
通讯作者：
Sakai Y

Dietary patterns and glucose tolerance abnormalities in Japanese men

DOI：
10.1093/jn/136.5.1352
发表时间：
2006-05-01
期刊：
JOURNAL OF NUTRITION
影响因子：
4.2
作者：
Mizoue, T;Yamaji, T;Kono, S
通讯作者：
Kono, S

Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study

DOI：
10.1111/j.1349-7006.2005.00077.x
发表时间：
2005-08-01
期刊：
CANCER SCIENCE
影响因子：
5.7
作者：
Hirose, M;Kono, S;Ikeda, N
通讯作者：
Ikeda, N

Relation of alcohol use and smoking to glucose tolerance status in Japanese men.

DOI：
10.1016/j.diabres.2005.12.010
发表时间：
2006-07
期刊：
Diabetes research and clinical practice
影响因子：
5.1
作者：
Y. Sakai;T. Yamaji;Shinji Tabata;S. Ogawa;K. Yamaguchi;M. Mineshita;T. Mizoue;S. Kono
通讯作者：
Y. Sakai;T. Yamaji;Shinji Tabata;S. Ogawa;K. Yamaguchi;M. Mineshita;T. Mizoue;S. Kono

The metabolic syndrome is associated with increased risk of colorectal adenoma development.

代谢综合征与结直肠腺瘤发展的风险增加有关。