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EPIDEMIOLOGICAL STUDY ON GREEN TER DRINKING AND SERUM LIPIDS

绿色饮料与血清脂质的流行病学研究

基本信息

批准号：
08457116
负责人：
KONO Suminori
金额：
$ 1.47万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457116/
关键词：
green tea Serum total cholesterol Serum triglyceridea HDL cholesterol Serum uric acid Liver function Blood pressure Coffee コレステロール胆石大腸ポリープ疫学血清脂質食事

项目摘要

A database of 7,637 male self-defense officials aged 48-59 was created by adding data of more than 2500 men to the previous data set of men receiving a preretirement health examination of the Self Defense Forces (SDF). This database included cross-sectional information on lifestyle factors and comprehensive medical data ; information on smoking, alcohol use, green tea consumption, coffee consumption, and 10 other food items in common throughout the survey period. Medical data included serum lipids, serum liver enzymes, serum uric acid, result of a 75-g oral glucose tolerance test, findings of gallbladder ultrasonography and colonoscopy. We investigated the relationship of green tea consumption with serum concentrations of total cholesterol, HDL cholesterol, and triglycerides in 7,391 men excluding those under hypolipidemic medication and others. After adjustment for hospital, study period, age, rank in the SDF, smoking, alcohol use, body mass index, glucose tolerance status determined … More by a 75-g oral glucose tolerance test, and coffee consumption. Mean concentrations of serum total cholesterol among men consuming 0, 1-3, 4-6, 7-9, and 10+ cups of green tea per day were 201.9, 199.4, 197.3, 200.0, and 196.3 mg/dl, respectively (trend p = 0.0007). Green tea consumption was not measurably related to either serum HDL cholesterol or triglycerides. The consumption of milk, bread for breakfast, soy paste soup, and raw vegetables each made a significant or nearly significant contribution to the variation of serum total cholesterol levels. After additional adjustment for these dietary variables, drinking one cup of green tea per day was associated with a decrease of 0.39 mg/dl (95% confidence interval 0.21-0.80) in serum concentrations of total cholesterol. Coffee consumption was not materially related to serum levels of total cholesterol, HDL cholesterol or triglycerides.We also investigated the relation between lifestyle factors other than green tea drinking and health-related biological parameters. Coffee drinking was found to be associated with lower levels of serum liver enzymes, serum uric acid, and lower blood pressure. Green tea drinking did not show such associations. Less

通过将2500多名男性的数据添加到之前接受自卫队退休前健康检查的男性数据集，创建了一个包含7,637名年龄在48-59岁之间的男性自卫官员的数据库。该数据库包括生活方式因素的横断面信息和综合医疗数据；调查期间吸烟、饮酒、绿茶、咖啡和其他10种常见食物的信息。医学资料包括血脂、血清肝酶、血清尿酸、75克口服葡萄糖耐量试验结果、胆囊超声检查和结肠镜检查结果。我们调查了7391名男性中绿茶摄入量与血清总胆固醇、高密度脂蛋白胆固醇和甘油三酯浓度的关系，不包括服用降血脂药物和其他药物的男性。在调整了医院、研究期间、年龄、SDF排名、吸烟、饮酒、体重指数、葡萄糖耐量状态后，更多的是通过75克口服葡萄糖耐量试验和咖啡摄入量。每天饮用0杯、1-3杯、4-6杯、7-9杯和10杯以上绿茶的男性血清总胆固醇的平均浓度分别为201.9、199.4、197.3、200.0和196.3 mg/dl（趋势p = 0.0007）。绿茶的摄入量与血清高密度脂蛋白胆固醇或甘油三酯没有可测量的关系。牛奶、早餐面包、豆酱汤和生蔬菜的摄入对血清总胆固醇水平的变化都有显著或接近显著的影响。在对这些饮食变量进行额外调整后，每天喝一杯绿茶与血清总胆固醇浓度降低0.39毫克/分升（95%置信区间0.21-0.80）有关。咖啡摄入量与血清总胆固醇、高密度脂蛋白胆固醇或甘油三酯水平没有实质性关系。我们还调查了绿茶饮用以外的生活方式因素与健康相关生物学参数之间的关系。研究发现，喝咖啡与血清肝酶、血清尿酸和低血压水平有关。喝绿茶则没有这种关联。少