Coordination Funds

协调基金

• 批准号: 460368285
• 负责人: Professor Dr. Bernd Löwe
• 金额: --
• 依托单位: Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/460368285?language=en
• 关键词: Coordination; Funds

Persistent Somatic Symptoms (PSS) are highly prevalent in all areas of medicine; they are disabling for patients and costly for society. The subjective symptom burden correlates poorly with the severity of the underlying disease, and patients’ needs for effective and tailored treatment are far from being met. There is initial evidence indicating that, in addition to disease-specific pathophysiological processes, psychological factors such as expectations of symptom severity, somatosensory amplification, and prior illness experiences contribute to symptom persistence in functional as well as in somatic diseases. However, especially for somatic diseases, there is a lack of prospective studies investigating the transition from acute to chronic somatic symptoms, integrating pathophysiological, psychological, and social factors. A better understanding of the multifactorial mechanisms of symptom persistence is crucial in order to develop targeted interventions for effective prevention and treatment of PSS.The overall aim of this interdisciplinary Research Unit is to identify generic and disease-specific risk factors and aetiological mechanisms of symptom persistence across a range of medical diseases, and thereby create a foundation for evidence-based interventions for PSS. Additional aims include the development of multivariate prediction models for PSS, the comparison of mechanisms for a chronic trajectory across diseases, the derivation of generic and disease-specific risk scores, and the modification of risk factors.Eight projects will investigate specific risk factors and mechanisms of symptom persistence in a total of 4044 patients with ten different medical conditions. All study designs are prospective and share common assessment points, core instruments, and outcome variables in order to allow comparison and validation of results across projects and diseases. Research in the first four-year funding phase will focus on the identification of generic and disease-specific mechanisms associated with unfavourable symptom course. The development of a prospective multivariate prediction model will facilitate the understanding of the course of PSS across diseases. In the second four-year funding phase, we will, apart from replicating and validating of the findings from the first funding phase, experimentally modify the most promising identified risk factors in order to improve clinical outcomes.Expected impact: This interdisciplinary Research Unit will fundamentally broaden our understanding of the development and persistence of somatic symptoms across various diseases. Comprehensive knowledge of these mechanisms will contribute to earlier recognition of patients at risk, and to the development of prevention and tailored treatment concepts for PSS across diseases. It will thereby create a foundation for improving medical care and quality of life of those affected by PSS.

持续性躯体症状（PSS）在医学的所有领域都非常普遍;它们使患者致残，并为社会带来高昂的代价。主观症状负担与基础疾病的严重程度相关性较差，患者对有效和定制治疗的需求远未得到满足。有初步的证据表明，除了疾病特异性的病理生理过程，心理因素，如预期的症状严重程度，体感放大，和以前的疾病经历有助于症状持续的功能以及躯体疾病。然而，特别是对于躯体疾病，缺乏前瞻性研究调查从急性到慢性躯体症状的转变，整合病理生理，心理和社会因素。更好地了解症状持续性的多因素机制是至关重要的，以制定有针对性的干预措施，有效的预防和治疗的PSS.这个跨学科的研究单位的总体目标是确定一般和疾病特异性的风险因素和病因机制的症状持续性在一系列的医学疾病，从而创造一个基础，以证据为基础的干预措施PSS。其他目标包括多变量预测模型的PSS的发展，跨疾病的慢性轨迹的机制的比较，通用和疾病特异性风险评分的推导，和修改的风险factors.Eight项目将调查特定的风险因素和机制的症状持续在总共4044例患者与10种不同的医疗条件。所有研究设计都是前瞻性的，并共享共同的评估点、核心工具和结果变量，以便对不同项目和疾病的结果进行比较和验证。第一个四年供资阶段的研究将侧重于确定与不利症状病程相关的一般和疾病特异性机制。一个前瞻性的多变量预测模型的发展将有助于理解跨疾病的PSS的过程。在第二个四年的资助阶段，我们除了复制和验证第一个资助阶段的发现外，还将通过实验修改最有希望的已确定的风险因素，以改善临床结果。预期影响：这个跨学科的研究单位将从根本上拓宽我们对各种疾病中躯体症状的发展和持续性的理解。对这些机制的全面了解将有助于早期识别处于风险中的患者，并有助于开发跨疾病PSS的预防和定制治疗概念。因此，它将为改善PSS患者的医疗保健和生活质量奠定基础。