Development of High Performance Blood Purification System using Novel Aromatic Polyimide Hollow Fiber

采用新型芳香族聚酰亚胺中空纤维开发高性能血液净化系统

• 批准号: 12480266
• 负责人: NAGAOKA Shoji
• 金额: $ 3.97万
• 依托单位: TOKYO METROPOLITAN UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12480266/
• 关键词: Blood Purification; Ultra filtration; Fluorinated Polyimide; Asymmetric Hollow Fiber; Fouling; Pore Size; Blood Compatibility; Tangential Module; ファウリング; 血液浄化; 持続的血液濾過膜; 中空糸膜

We report the application of aromatic fluorinated polyimide (6FDA-6FAP) to high performance continuous blood purification system for acute renal failure. For this purpose, a series of porous polyimide membranes were fabricated by different conditions, and micro to nanofiltration membranes was obtained. We focused on a wet phase inversion process as method for preparing a novel porous membrane, since the membrane with nano-order-scale fine structure designed from nanoscale nodule or pore sizes is of great interest in areas such as medical device for clinical use. The obtained membrane showed good ultra filtration rate and anti-fouling property. The various conditions to fabricate asymmetric porous hollow fiber were determined. Also, we found that the porous membrane showed excellent blood and immune compatibility both in vivo and in vitro by the selective and oriented adsorption of IgG on the surface. We have manufactured for trial the tangential module for clinical use.

本文报道了芳香族含氟聚酰亚胺（6 FDA-6 FAP）在急性肾功能衰竭高性能连续性血液净化系统中的应用。为此，通过不同的条件制备了一系列聚酰亚胺多孔膜，并得到了微纳滤膜。我们专注于湿相转化过程作为制备新型多孔膜的方法，因为具有由纳米级结节或孔径设计的纳米级精细结构的膜在临床使用的医疗器械等领域具有极大的兴趣。所得膜具有良好的超滤速率和抗污染性能。确定了制备非对称多孔中空纤维的各种条件。此外，我们发现，多孔膜显示出良好的血液和免疫相容性，在体内和体外的选择性和定向吸附的IgG在表面上。我们已经制造了用于临床使用的切向模块进行试验。

项目成果

Niwa M., Kawakami H., Nagaoka S., et al.: "Gas transfer and blood compatibility of asymmetric polyimide hollow fiber"J.Biomat.Sci.Ploym.Edn.. 12(5). 533-542 (2001)

Niwa M.、Kawakami H.、Nagaoka S.等人：“不对称聚酰亚胺中空纤维的气体传输和血液相容性”J.Biomat.Sci.Ploym.Edn.. 12(5)。

Kanno M., Kawakami H., Nagaoka S.et al.: "Biocompatibility of Fluorinated Polyimide"J.Biomed.Mater.Res.. (印刷中). (2002)

Kanno M.、Kawakami H.、Nagaoka S.等人：“氟化聚酰亚胺的生物相容性”J.Biomed.Mater.Res..（出版中）。

Niwa M., Kawakami H., Nagaoka S et al.: "Gas Separation of Asymmetric 6FDA Polyimide Membrane with Oriented Surface Skin Layer"Macromolecules. 34(26). 9039-9044 (2001)

Niwa M.、Kawakami H.、Nagaoka S 等人：“具有定向表面皮层的不对称 6FDA 聚酰亚胺膜的气体分离”大分子。

H. Kawakami, T. Takahashi, S. Nagaoka, and Y. Nakayama: "Albumin Adsorption to Surface of Annealed Fluorinated Polyimide"Polym. Adv. Technol. 12. 244-252 (2001)

H. Kawakami、T. Takahashi、S. Nagaoka 和 Y. Nakayama：“白蛋白对退火氟化聚酰亚胺表面的吸附”聚合物。

T. Kanamori, M. Niwa, H. Kawakami, Y. Mori, S. Nagaoka, and T. Shinbo: "Preparation of Asymmetric Hollow-Fiber Membrane with Ultrathin Dense Skin"Macromol. Sympo.. 160. 233-237 (2000)

T. Kanamori、M. Niwa、H. Kawakami、Y. Mori、S. Nagaoka 和 T. Shinbo：“具有超薄致密表皮的不对称中空纤维膜的制备”Macromol。