Development of High Performance Blood Purification System using Novel Aromatic Polyimide Hollow Fiber

本文报道芳香族氟化聚酰亚胺（6FDA-6FAP）在急性肾功能衰竭的高性能连续血液净化系统中的应用。为此，在不同条件下制备了一系列多孔聚酰亚胺膜，得到了微纳滤膜。我们专注于湿相转化工艺作为制备新型多孔膜的方法，因为由纳米级结节或孔径设计的纳米级精细结构的膜在临床使用的医疗设备等领域具有很大的兴趣。所得膜具有良好的超滤率和抗污性能。确定了制备不对称多孔中空纤维的各种条件。此外，我们发现多孔膜在体内和体外都表现出良好的血液和免疫相容性，通过在表面选择性和定向吸附IgG。我们已经制造了用于临床试验的切向模块。

We report the application of aromatic fluorinated polyimide (6FDA-6FAP) to high performance continuous blood purification system for acute renal failure. For this purpose, a series of porous polyimide membranes were fabricated by different conditions, and micro to nanofiltration membranes was obtained. We focused on a wet phase inversion process as method for preparing a novel porous membrane, since the membrane with nano-order-scale fine structure designed from nanoscale nodule or pore sizes is of great interest in areas such as medical device for clinical use. The obtained membrane showed good ultra filtration rate and anti-fouling property. The various conditions to fabricate asymmetric porous hollow fiber were determined. Also, we found that the porous membrane showed excellent blood and immune compatibility both in vivo and in vitro by the selective and oriented adsorption of IgG on the surface. We have manufactured for trial the tangential module for clinical use.