Instrument and Method for Forming Three-Dimensional Ultrasound Images of the Brea

用于形成布雷亚三维超声图像的仪器和方法

• 批准号: 8711846
• 负责人: ROBERT A KRUGER
• 金额: $ 22.5万
• 依托单位: OPTOSONICS, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8711846
• 关键词: Breast; Breast Microcalcification; Data; Data Collection; Elements; Hemoglobin; Image; Imaging Device; Mammary Gland Parenchyma; Mammography; Maps; Methods; Noise; Phase; Physiologic pulse; Resolution; Sampling; Scanning; Signal Transduction; Speed; Three-Dimensional Image; Transducers; Ultrasonography; Variant; Work; base; improved; instrument; malignant breast neoplasm; photoacoustic imaging; prototype; public health relevance; reconstruction; screening; soft tissue; sound

High Definition Ultrasound for Mammography Abstract We propose to develop High Definition Ultrasound (HD-US) based on a hemispherical synthetic aperture and backscattered sonic waves. This configuration will produce direct three-dimensional maps of ultrasound reflectivity of breast tissues, and will display higher signal-to-noise, reduced speckle and greater spatial resolution compared to ultrasound arrays based on linear or curved planar sampling apertures. Our prototype hemispherical array consists of four interdigitated sub-arrays, each having 128 discrete elements. Currently, this array is used to capture 3D photoacoustic images of the whole breast using a spiral scanning strategy to increase the field of view sufficiently to perform whole-breast screening - PhotoAcoustic Mammography (PAM). In Phase I of this work, we will add a multiplexed pulser, pulse sequencer and T/R switches to capture ultrasound reflectivity data sufficient to form a 3D ultrasound image using the same reconstruction strategy used in PAM. Full 3D image acquisition will take 3.4 minutes, the same as currently used for PAM data collection. Spatial resolution and low contrast detectability will be quantified using anthropomorphic phantoms. In Phase II, HD-US will be combined with PAM to produce 3D images of soft tissue and microcalcifications. The 3D images will be co-registered with the PAM images of hemoglobin distribution in the breast using a single hemispherical transducer array.

用于乳房x光检查的高清晰度超声