Mapping Brain Region Activity During Chewing a Functional Magnetic Resonance Imageing Study

功能性磁共振成像研究绘制咀嚼过程中的大脑区域活动图

• 批准号: 12557173
• 负责人: NISHIYAMA Katsuhiro
• 金额: $ 4.29万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12557173/
• 关键词: Human; Mastivation System; Neurone; Brain Activastion; Hippocampal; Gum Chewing; Molar Teeth; functional magnetic resonance imaging; 高齢化; fMRl; 加齢; ラット; ヒト

Mastication has been suggested to increase neuronal activities in various regions of the human brain. However, because of technical difficulties, the fine anatomical and physiological regions linked to mastication have not been fully elucidated. Using functional magnetic resonance imaging during cycles of rhythmic gum-chewing and no chewing, we therefore examined the interaction between chewing and brain regional activity in 17 subjects (aged 20-31 years). In all subjects, chewing resulted in a bilateral increase in BOLS oxygenation level-dependent (BOLD) signals in the sensor motor cortex, supplementary motor area, insula, thalamus, and cerebellum. In addition, in the first three regions, chewing of moderately hard gum produced stronger blod signals than the chewing of hard gum. However, the signal was higher in the cerebellum and not significant in the thalamus, respectively. These results suggest that chewing causes regional increase in brain neuronal activities which are related to biting force.

咀嚼被认为可以增加人脑各个区域的神经元活动。然而，由于技术上的困难，与咀嚼有关的精细解剖和生理区域尚未完全阐明。因此，我们在17名受试者（年龄20-31岁）中使用功能性磁共振成像在有节奏咀嚼口香糖和不咀嚼口香糖的周期中检查了咀嚼和大脑区域活动之间的相互作用。在所有受试者中，咀嚼导致双侧BOLS氧合水平依赖性（BOLD）的传感器运动皮层，辅助运动区，小脑，丘脑和小脑的信号增加。此外，在前三个区域，咀嚼中等硬度的口香糖比咀嚼硬质口香糖产生更强的blod信号。然而，信号在小脑中较高，而在丘脑中不显著。这些结果表明，咀嚼导致与咬合力相关的脑神经元活动的区域增加。

项目成果

Watanabe K., Fujita M., Onozuka M.: "Evidence for involvement of dysfunctional teeth in the senile process in the hippocampus of SAMP8 mice"Exp Gerontol. 36(2). 283-295 (2001)

Watanabe K.、Fujita M.、Onozuka M.：“功能失调的牙齿参与 SAMP8 小鼠海马衰老过程的证据”Exp Gerontol。

Watanabe K, Ozono S, Nishiyama K, Fuiita M. Onozuka M: "The molarless condition in aged SAMP8 mice attenuates hippocampal Fos induction linked to water maze performance"Behav Brain Res.. 128(1). 19-25 (2002)

Watanabe K、Ozono S、Nishiyama K、Fuiita M. Onozuka M：“老年 SAMP8 小鼠的无磨牙条件减弱了与水迷宫性能相关的海马 Fos 诱导”Behav Brain Res.. 128(1)。

Watanabe K., Ozono S., Nishiyama K., Fujita M., Onozuka M.: "The molarless condition in aged SAMP8 mice attenuates hippocampal Fos induction linked to water maze performance"Behav Brain Res.. 128(1). 19-25 (2002)

Watanabe K.、Ozono S.、Nishiyama K.、Fujita M.、Onozuka M.：“老年 SAMP8 小鼠的无磨牙条件减弱了与水迷宫性能相关的海马 Fos 诱导”Behav Brain Res.. 128(1)。

Onozuka M., Fujita M., Watanabe K., Nishiyama K.: "Mapping brain region activity during chewing: a functional magnetic resonance imaging study"J Dent Res.. 81(11). 743-746 (2002)

Onozuka M.、Fujita M.、Watanabe K.、Nishiyama K.：“绘制咀嚼过程中的大脑区域活动：功能性磁共振成像研究”J Dent Res.. 81(11)。

Onozuka M., Watanabe K., Fujita M.: "Evidence for involvement of glucocorticoid response in the hippocampal changes in aged molarless SAMP8 mice"Behav Brain Res.. 131(1-2). 125-129 (2002)

Onozuka M.、Watanabe K.、Fujita M.：“糖皮质激素反应参与老年无磨牙 SAMP8 小鼠海马变化的证据”Behav Brain Res.. 131(1-2)。