IFNy-induced cell state transition in melanoma (A13)

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Paschen uncovered that interferon-γ (IFNγ) induces an epithelial-to-mesenchymal (EMT)-like cell state transition leading to drug resistance, and that this is connected to expression of the stress-induced transcription factor ATF4. Her project aims to understand how ATF4 leads to EMT-like dedifferentiation by unravelling the ATF4-controlled gene network to identify drugga-ble targets. Her approach will involve chemical modulation and single cell analyses to monitor dynamics and heterogeneity of the IFNy-induced cell state. Her work aims to identify new ther-apeutic targets to improve the efficacy of future tumour immunotherapies.