IFNy-induced cell state transition in melanoma (A13)

黑色素瘤中 IFNγ 诱导的细胞状态转变 (A13)

• 批准号: 460672911
• 金额: --
• 依托单位: Klinik für Dermatologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/460672911?language=en
• 关键词: IFNy; induced; cell; state; transition

Paschen uncovered that interferon-γ (IFNγ) induces an epithelial-to-mesenchymal (EMT)-like cell state transition leading to drug resistance, and that this is connected to expression of the stress-induced transcription factor ATF4. Her project aims to understand how ATF4 leads to EMT-like dedifferentiation by unravelling the ATF4-controlled gene network to identify drugga-ble targets. Her approach will involve chemical modulation and single cell analyses to monitor dynamics and heterogeneity of the IFNy-induced cell state. Her work aims to identify new ther-apeutic targets to improve the efficacy of future tumour immunotherapies.

Paschen发现，干扰素-γ（IFNγ）诱导上皮细胞向间充质细胞（EMT）样细胞状态转变，导致耐药性，这与应激诱导的转录因子ATF 4的表达有关。她的项目旨在了解ATF 4如何通过解开ATF 4控制的基因网络来识别药物靶点，从而导致EMT样去分化。她的方法将涉及化学调节和单细胞分析，以监测IFNy诱导的细胞状态的动态和异质性。她的工作旨在确定新的治疗靶点，以提高未来肿瘤免疫疗法的疗效。