A Study of Risk Evaluation for Mutagenic Activity in Air on Human Carcinogenecity and Genotoxicity in an Industrial Area in Shenyang, China

沉阳某工业区空气致突变活性对人类致癌性和遗传毒性的风险评价研究

• 批准号: 12575034
• 负责人: YAMAUCHI Toru
• 金额: $ 9.6万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12575034/
• 关键词: Mutagenic activity; PAHs; Atmospheric air; respiratory complains; respiratory functions; micro nucleus; DNA polymorphism; genotosicity; carcinogenecity; cancer mortality; 環境保健疫学調査; 中国瀋陽市工業地区; 大気汚染; 大気中変異原活性; 変異原性物質; 小核試験; 薬物代謝酵素の遺伝子多型; 肺癌

We investigated the effect of mutagenic activity in atmospheric air on residential health in a polluted area of Shenyang City, China, from 2000 to 2002. 1. The concentration of 9 polycyclic aromatic hydrocarbons (PAHs) in air ranged from 10 to 906ng/m^3 and showed the highest levels in the industrial area and the near trunk road junction in winter. The annual average of mutagenic activity was high for TA100(+S9) and low for TA98(-S9). 2 The concentration of 13 heavy metals in suspended particles showed the highest levels in the industrial area followed by the near trunk road junction. The level of As, Cr and Ni as carcinogenic metals were 57.4, 206.0 and 69.5ng/m^3, respectively, and were about 40, 30 and 10 times as much as those in Mie prefecture, Japan. 3. The prevalence rates of respiratory complains were significantly higher in the polluted area than in control area for not only subject themselves but their parents. Moreover, the prevalence rate of lung cancer in parents was also … More significantly higher in the polluted area than in control area. The rate of the history of abortion and/or still birth in the married female subjects was significantly higher in the polluted area than in control area. The respiratory functions of the non-smoke female subjects indicating the disturbance of the peripheral air way such as FEV1.0%, V25 and V25/Ht were significantly lower averages in the pollutes area than in control area. 4. To evaluate the genotoxic effects of atmospheric air pollution in vivo and in vitro, we aimed to assess prospectively the association between air pollution level and genetic damage in vivo and in vitro in industrial and rural areas in Shenyang. After adjustment for potential confounders, individuals who live in industrial area had received greater genotoxicities and air samples from industrial area indicated that higher mutagenecities in bacterial assay (Ames test). 5. The age adjusted mortality (AAM) of whole cancers and lung cancer for 1996-2000 were compared between Shenyang City and Japan, and the air polluted and control areas. The AAM of whole cancers ranged 260-275 in male and 134-177 per 10^5 population in female in Shenyang City, and were about 1.2 in male and 1.5 times in female as much as in Japan. The AAM of whole cancers was higher in the pollute area than in control area. The AAM of lung cancer was higher in the polluted area than in control area in 1996, but the difference of both rates was decreased year by year and none was found in 2000. Less

2000年至2002年，在沈阳市中国污染区，调查了大气中的致突变物质对居民健康的影响。1.大气中9种多环芳烃(PAHs)的浓度变化范围为10~906 ng/m~3，冬季以工业区和主干道交叉口附近最高。TA100(+S9)的年平均致突变活性较高，TA98(-S9)的年平均致突变活性较低。2悬浮颗粒物中13种重金属的浓度以工业区最高，其次为主干道交叉口附近。致癌金属As、Cr和Ni的含量分别为57.4、206.0和69.5 ng/m~3，约为日本三叶县的40、30和10倍。3.无论是受试者本人，还是其父母，污染区呼吸道主诉的患病率均显著高于对照区。此外，父母的肺癌患病率也是…污染区明显高于对照区。污染区已婚女性流产率和/或死胎率明显高于对照区。污染区非吸烟女性受试者反映周围呼吸道功能障碍的FEV1.0%、V25、V25/Ht平均值明显低于对照地区。4.为了评价大气污染的体内外遗传毒性效应，我们前瞻性地评价了沈阳市工业和农村大气污染水平与体内外遗传损伤的关系。在调整了潜在混杂因素后，工业区的个体受到了更大的遗传毒性，工业区的空气样品在细菌检测(Ames试验)中显示出更高的致突变性。5.比较沈阳市与日本、空气污染区和对照地区1996-2000年全癌和肺癌的年龄调整死亡率。沈阳市全癌AAM男性为260~275，女性为134~177/10万，约为日本的1.2倍和1.5倍。污染区全癌AAM高于对照区。1996年污染区肺癌AAM高于对照区，但两者差值逐年缩小，2000年未发现肺癌AAM。较少