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Integration of cognitive and motivational information for decision making psychophysiological studies

整合认知和动机信息进行决策心理生理学研究

基本信息

批准号：
13410029
负责人：
WATANABE Masataka
金额：
$ 9.34万
依托单位：
Tokyo Metropolitan Organization for Medical Research
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

1.We investigated neuronal mechanisms on how cognitive and motivational information contributes to the behavior of the monkey and how these two kinds of information interact. We trained monkeys on either or both of (1)(spatial and object) delayed response task and (2)delayed reaction time task, using several different kinds of rewards.2.We found, in the lateral prefrontal cortex, not only those neurons that were related to "reward expectancy" but also those that were related to "no-reward expectancy" that was concerned with anticipating the outcome of the absence of the specific reward.3.In the orbitofrontal cortex, we found two different kinds of reward expectancy processes ; long and short -range reward expectancy that were concerned with anticipating the specific reward that would be delivered in the future, and that were concerned with expecting the specific reward that would be delivered soon, respectively.4.In a monkey PET study, we did not find any activation in the lateral prefrontal cortex during the monkey's spatial delayed response task performance as compared with control task without delay. Comparison between the spatial and object delayed response tasks, the premotor area was more active during the former while the ventral prefrontal areas were more active during the latter task performance.5.In a microdialysis study, we examined dopamine and glutamate concentration in the prefrontal cortex when the monkey was performing the spatial delayed response task and no-delay spatial control task as well as monkey's resting state. We found increase in dopamine, but no change in glutamate during the delayed response task while we found increase in glutamate, but no change in dopamine during the control task.

1.我们研究了认知和动机信息对猴子行为的影响以及这两种信息如何相互作用的神经机制。我们用（1）中的一种或两种方法训练猴子（2）延迟反应时任务。2.我们发现，在外侧前额叶皮层，不仅是那些与“奖励期望”相关的神经元，3.在眶额皮层，我们发现了两种不同的奖励期望过程;长期和短期奖励期望，它们关注的是对未来会得到的特定奖励的预期，以及对即将得到的特定奖励的预期，4.在一项猴子PET研究中，我们没有发现与无延迟的控制任务相比，在猴子的空间延迟反应任务执行过程中，外侧前额叶皮层有任何激活。空间延迟反应任务和物体延迟反应任务比较，前者运动前区更活跃，而后者任务执行时腹侧前额叶区更活跃。5.微透析技术检测了猕猴在执行空间延迟反应任务和无延迟空间控制任务时前额叶皮层多巴胺和谷氨酸的含量以及安静状态。我们发现在延迟反应任务中多巴胺增加，但谷氨酸没有变化，而我们发现在控制任务中谷氨酸增加，但多巴胺没有变化。